| Entry |
Thumbnail Image |
Name |
Description |
Object |
Legend |
|
hsa05207
|
|
Chemical carcinogenesis - receptor activation |
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stage... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 10000 (AKT3), 2... |
CHEMICAL CARCINOGENESIS - RECEPTOR ACTIVATION EGFR DNA Ras Raf MEK ERK1/2 DNA PKA pCREB MAPK sig... |
|
hsa04070
|
|
Phosphatidylinositol signaling system |
|
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 23396 (PIP5K1C)... |
PTEN 2.7.1.158 PI(3,4)P PI(3,5)P PI(5)P PLC PLC 5PP-IP Focal adhesion I(1,3,4)P I(1,3,4,5)P I(4)P I(... |
|
hsa05203
|
|
Viral carcinogenesis |
There is a strong association between viruses and the development of human malignancies. We now know... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 4790 (NFKB1), 4... |
VIRAL CARCINOGENESIS Hepatitis C virus (HCV) Hepatocellular carcinoma Human papillomavirus (HPV) p... |
|
hsa04081
|
|
Hormone signaling |
|
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 5741 (PTH) 5745... |
|
|
hsa04517
|
|
IgSF CAM signaling |
Immunoglobulin superfamily cell adhesion molecules (IgSF CAMs) are cell surface proteins that mediat... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 2534 (FYN) 1000... |
|
|
hsa04931
|
|
Insulin resistance |
Insulin resistance is a condition where cells become resistant to the effects of insulin. It is ofte... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 10000 (AKT3), 2... |
JNK1 TNFα FFA ER stress TNFR1 FATPs FFA IKKβ mTOR S6K INSR IRS-1 PI3K AKT2 GSK-3 +py LCFA-CoA DAG PK... |
|
hsa05163
|
|
Human cytomegalovirus infection |
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-her... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 1956 (EGFR) 356... |
PIP 4EBPs S6K1/2 mTOR Rheb TSC2 TSC1 AKT PI3K HUMAN CYTOMEGALOVIRUS INFECTION EGFR FasL IKK NF κB ... |
|
hsa05205
|
|
Proteoglycans in cancer |
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 10000 (AKT3), 2... |
CD44v3 Tiam1 HER2 RhoA ROCK Ankyrin Cytoskeleton activation PI3K AKT CD44 Lipid Raft IP3R CAMKII Fil... |
|
hsa05224
|
|
Breast cancer |
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breas... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 10000 (AKT3), 2... |
BREAST CANCER EGFR CoR Ras Raf MEK ERK1/2 Shc Grb2 SOS Estrogen signaling pathway Jagged Notch mTOR... |
|
hsa05235
|
|
PD-L1 expression and PD-1 checkpoint pathway in cancer |
Programmed cell death 1 (PD1) and its ligand (PDL1) are key regulatory physiological immune checkpoi... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 10125 (RASGRP1)... |
PIP IκB NFκB IKK AKT PI3K RasGRP1 Ras AP1 NFAT CaN PLC-γ1 ZAP70 CD3ε CD3δ TCRβ TCRα CD3ζ CD3ζ CD3γ C... |
|
hsa04014
|
|
Ras signaling pathway |
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating c... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 25759 (SHC2), 3... |
MAPK signaling pathway RAS SIGNALING PATHWAY ERK MEK Raf-1 Ras PI3K-Akt signaling pathway Grb2 SOS... |
|
hsa04071
|
|
Sphingolipid signaling pathway |
Sphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a ... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 5170 (PDPK1) 55... |
ERK1/2 MEK1/2 Raf AKT P13K PDK1 PIP SPHINGOLIPID SIGNALING PATHWAY MAPK signaling pathway P... |
|
hsa04151
|
|
PI3K-Akt signaling pathway |
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellul... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 5728 (PTEN) 366... |
PIP eIF4E 4EBPs eIF4B S6K1/2 Raptor mTOR GβL Rheb TSC2 TSC1 AKT PDK1 PI3K p53 signaling pathway mTOR... |
|
hsa04213
|
|
Longevity regulating pathway - multiple species |
Aging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 3479 (IGF1) 348... |
FOXO S6K mTOR Akt P13K PIP LONGEVITY REGULATING PATHWAY - MULTIPLE SPECIES DNA IGF-I IGF-IR IRS1... |
|
hsa04218
|
|
Cellular senescence |
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of f... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 10000 (AKT3), 2... |
CELLULAR SENESCENCE NORE1A PP1A C-Myc HIPK2 ARF MDM2 p53 P53 signaling pathway PI3K AKT TSC1/2 RHEB... |
|
hsa04550
|
|
Signaling pathways regulating pluripotency of stem cells |
Pluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the poten... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 10000 (AKT3), 2... |
Wnt APC Axin Dvl Frizzled SIGNALING PATHWAYS REGULATING PLURIPOTENCY OF STEM CELLS β-catenin G... |
|
hsa04670
|
|
Leukocyte transendothelial migration |
Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. ... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 1499 (CTNNB1) 6... |
CAMs MMPs CAMs SHP-2 CDH5 CD99 PECAM1 ITGB2 p120ctn p130 AF-6 SPA-1 PECAM1 JAM1 ITGAL CDH5 SHP-2 CD9... |
|
hsa04914
|
|
Progesterone-mediated oocyte maturation |
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the s... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 983 (CDK1) 1000... |
IGF1R IGF-1 Insulin Mos CPEB CycB1/B4 Cdc2 Ras PI3K Cdc2 PIP , PIP Akt/PKB PDE3 APC/C Fizzy Mad1/2/3... |
|
hsa04915
|
|
Estrogen signaling pathway |
Estrogens are steroid hormones that regulate a plethora of physiological processes in mammals, inclu... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 10000 (AKT3), 2... |
ESTROGEN SIGNALING PATHWAY GPER c-Src MMP HB-EGF EGFR HB-EGF DNA DNA cAMP PKA Ras Raf MEK ERK1/2 p... |
|
hsa04917
|
|
Prolactin signaling pathway |
Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological function... |
... (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3) 5594 (MAPK1), 5... |
Jak_STAT signaling pathway MAPK signaling pathway PIP Akt/PKB PI3K PROLACTIN SIGNALING PATHWAY ERK... |