| Entry |
Thumbnail Image |
Name |
Description |
Object |
Legend |
|
hsa03320
|
|
PPAR signaling pathway |
...and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different ... |
... 2171 (FABP5), 2172 (FABP6), 2173 (FABP7) 5465 (PPARA) 6256 (RXRA), 6257 (RXRB), 6258 (RXRG) 5467 (P... |
Unsaturated fatty acid Unsaturated fatty acid Saturated fatty acid Eicosanoid Fibrate drug NSAID 9-c... |
|
hsa04924
|
|
Renin secretion |
...: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and... |
C00575 (3',5'-Cyclic AMP) C00788 (L-Adrenaline) C00547 (L-Noradrenaline) C00942 (3',5'-Cyclic GMP) C... |
RENIN SECRETION AC5/6 PKA cAMP β-AR Epinephrine Norepinephrine NPR-A cAMP signaling pathway cGMP cG... |
|
hsa03030
|
|
DNA replication |
...In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core)... |
3978 (LIG1) 2237 (FEN1) 1763 (DNA2) 10535 (RNASEH2A) 79621 (RNASEH2B) 5982 (RFC2), 5984 (RFC4) 84153... |
Lig1 Fen1 Dna2 RNaseH2A RNaseH2B RFC2/4 RNaseH2C RFC3/5 PCNA RPA3 Mcm5 SSB DnaG DNA REPLICATION γ &... |
|
hsa03050
|
|
Proteasome |
The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such... |
3458 (IFNG) 5709 (PSMD3) 5718 (PSMD12) 5717 (PSMD11) 9861 (PSMD6) 5713 (PSMD7) 5719 (PSMD13) 10213 (... |
IFNγ Rpn1 Rpn2 Rpn10 Rpn11 Lid Base 20S Core Particle Regulatory Particle 19S 26S proteasome (PA700)... |
|
hsa05207
|
|
Chemical carcinogenesis - receptor activation |
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stage... |
... 6258 (RXRG) 1543 (CYP1A1), 1544 (CYP1A2) 5465 (PPARA) 6256 (RXRA), 6257 (RXRB), 6258 (RXRG) 5465 (P... |
CHEMICAL CARCINOGENESIS - RECEPTOR ACTIVATION EGFR DNA Ras Raf MEK ERK1/2 DNA PKA pCREB MAPK sig... |
|
hsa04024
|
|
cAMP signaling pathway |
cAMP is one of the most common and universal second messengers, and its formation is promoted by ade... |
...AD) 2737 (GLI3) 4790 (NFKB1), 5970 (RELA) 5465 (PPARA) 4772 (NFATC1) 1387 (CREBBP), 2033 (EP300) 666... |
cAMP SIGNALING PATHWAY Sarcoplasmic Reticulum (SR) VDCC RyR2 SERCA2a TnI Calcium signaling pathway... |
|
hsa04920
|
|
Adipocytokine signaling pathway |
Increased adipocyte volume and number are positively correlated with leptin production, and negative... |
...), 5571 (PRKAG1) 9370 (ADIPOQ) 32 (ACACB) 5465 (PPARA) 51094 (ADIPOR1), 79602 (ADIPOR2) 5588 (PRKCQ)... |
Ceramide Long-chain fatty acid Retinoic acid NF-κB IκB SHP-2 SOCS3 CPT-1 G6PC PEPCK FACS Diglyceride... |
|
hsa04922
|
|
Glucagon signaling pathway |
Glucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical ... |
...11 (SIRT1) 23411 (SIRT1) 10891 (PPARGC1A) 5465 (PPARA) |
GLUCAGON SIGNALING PATHWAY GLUT1/2 Glucose G6P Pyruvate Glucose Citrate cycle (TCA cycle) Citrate ... |
|
hsa04931
|
|
Insulin resistance |
Insulin resistance is a condition where cells become resistant to the effects of insulin. It is ofte... |
...8 (G6PC2), 92579 (G6PC3) 10891 (PPARGC1A) 5465 (PPARA) 57761 (TRIB3) 10062 (NR1H3), 7376 (NR1H2) 672... |
JNK1 TNFα FFA ER stress TNFR1 FATPs FFA IKKβ mTOR S6K INSR IRS-1 PI3K AKT2 GSK-3 +py LCFA-CoA DAG PK... |
|
hsa04932
|
|
Non-alcoholic fatty liver disease |
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to mor... |
... 8503 (PIK3R3) 2931 (GSK3A), 2932 (GSK3B) 5465 (PPARA) 9370 (ADIPOQ) 51422 (PRKAG2), 53632 (PRKAG3),... |
NON-ALCOHOLIC FATTY LIVER DISEASE Simple steatosis (without inflammation and fibrosis) (Cirrhos... |
|
hsa04936
|
|
Alcoholic liver disease |
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol ov... |
...23411 (SIRT1) 29896 (TRA2A), 6434 (TRA2B) 5465 (PPARA) 1374 (CPT1A) 37 (ACADVL) 34 (ACADM) 51 (ACOX1... |
MyD88 TRAF3 IFN-β IFN-α TAK1 IRAK1 IL-8 TIRAP IL-1β TBK1 TRAF6 IKKε IL-6 TAB1 TAB2 IκBα TNFα IRF3 MD... |
|
hsa05160
|
|
Hepatitis C |
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies... |
...(NR1H3) 3949 (LDLR) 572 (BAD) 6256 (RXRA) 5465 (PPARA) 3458 (IFNG) 7124 (TNF) 3627 (CXCL10) 4938 (OA... |
HEPATITIS C Hepatitis C virus Hepatocyte RIG-I IPS-1 TRAF3 TBK1 IKKε IRF3/7 NFκB TLR3 TRIF IκB IKK ... |
|
hsa05415
|
|
Diabetic cardiomyopathy |
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients ... |
...KCB) 2673 (GFPT1), 9945 (GFPT2) 183 (AGT) 5465 (PPARA) 10105 (PPIF), 291 (SLC25A4), 292 (SLC25A5), 2... |
FFA FFA LCFA-CoA DAG PKCα/δ FAT/CD36 Cer PP2A DIABETIC CARDIOMYOPATHY PKCβ Glucose Glucose UDP-GlcNA... |
|
hsa00510
|
|
N-Glycan biosynthesis |
N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glyc... |
G10596 G00022 G00021 G00020 G00019 G00018 (DS 3) G00017 G00016 (Core fucose) G00015 G00014 G00013 G0... |
...ALG7 3.1.3.51 2.7.1.108 Cytosol ER lumen Golgi apparatus N-glycan precursor biosynthesis Trimming to... |