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Thumbnail Image |
Name |
Description |
Object |
Legend |
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hsa04141
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Protein processing in endoplasmic reticulum |
... toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Acc... |
G00010 C00076 (Calcium cation) G00010 G00009 G00011 G00011 G10694 G00012 468 (ATF4) 1649 (DDIT3) 559... |
PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM Protein export Apoptosis Proteasome ATF4 CHOP JNK TR... |
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hsa04612
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Antigen processing and presentation |
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972 (CD74) 972 (CD74) 3108 (HLA-DMA), 3109 (HLA-DMB), 3111 (HLA-DOA), 3112 (HLA-DOB), 3113 (HLA-DPA1... |
...city T cell receptor signaling pathway ANTIGEN PROCESSING AND PRESENTATION MHC I pathway MHC II p... |
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hsa00910
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Nitrogen metabolism |
The biological process of the nitrogen cycle is a complex interplay among different microorganisms c... |
C00058 (Formate) C00488 (Formamide) C00014 (Ammonia) C00192 (Hydroxylamine) C06058 (Nitroalkane) C00... |
Formate Formamide 3.5.1.49 Ammonia Hydroxylamine Nitroalkane 1.7.2.6 1.9.6.1 1.7.99.- 1.7.7.2 1.13.1... |
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hsa04610
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Complement and coagulation cascades |
...plicated in many physiological and pathological processes including the regulation of blood pressure... |
...3 (F5) 2243 (FGA), 2244 (FGB), 2266 (FGG) 5624 (PROC) 2162 (F13A1), 2165 (F13B) 2149 (F2R) 1361 (CPB... |
COMPLEMENT AND COAGULATION CASCADES Plasmin Coagulation cascade Extrinsic pathway Tissue damage F... |
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hsa04210
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Apoptosis |
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... |
C00076 (Calcium cation) C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C00319 (Sphingosine) C0002... |
...AILR2 tBid TRAF2 Ire1α CASP12 ER stress Protein processing in endoplasmic reticulum FAP1 FLIP Gadd45... |
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hsa03018
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RNA degradation |
The correct processing, quality control and turnover of cellular RNA molecules are critical to many ... |
2023 (ENO1), 2026 (ENO2), 2027 (ENO3) 87178 (PNPT1) 54512 (EXOSC4) 23016 (EXOSC7) 9652 (SKIC3) 80349... |
RNase E RNase E RNase E RhlB Enolase PNPase RhlE RNaseR helicases Rho RNA degradosome type A (Esche... |
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hsa03410
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Base excision repair |
...e predominant DNA damage repair pathway for the processing of small base lesions, derived from oxida... |
328 (APEX1) 2237 (FEN1) 3978 (LIG1) 3980 (LIG3) 3978 (LIG1) 54107 (POLE3), 5426 (POLE), 5427 (POLE2)... |
APEX Fen1 Lig1 Lig3 Lig Polε Polδ Polβ Polβ Polβ Polβ PCNA PCNA PCNA DpoI DpoI DpoI APEX Nfo Xth MUT... |
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hsa04020
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Calcium signaling pathway |
...he rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels,... |
C01330 (Sodium cation) C00076 (Calcium cation) C13050 (Cyclic ADP-ribose) C13051 (Nicotinic acid ade... |
Long term depression Long term potentiation Phosphatidylinositol signaling pathway Apoptosis ... |
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hsa04062
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Chemokine signaling pathway |
...ion, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular ac... |
C00165 (Diacylglycerol) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00076 (Calcium cation) C00575 (... |
Migration Apoptosis Degranulation Cellular shape changes Cell survival chemokineR chemokine JAK2/3 ... |
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hsa04146
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Peroxisome |
...asis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis... |
5195 (PEX14) 5828 (PEX2) 5189 (PEX1) 5190 (PEX6) 55670 (PEX26) 5194 (PEX13) 5192 (PEX10) 5193 (PEX12... |
PEROXISOME PEX14 PEX2 PEX1 PEX6 PEX26 PEX13 PTS1 PTS2 Matrix protein import PEX10 PEX12 PEX5 PEX7 PE... |
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hsa04666
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Fc gamma R-mediated phagosome formation |
...s, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00165... |
Macrophage Monocyte Neutrophil FcγRIIIA FcγRIIB FcγRIIA FcγRI Src Syk CD45 IgG PI3K SHIP LAT PIP PLC... |
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hsa04730
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Long-term depression |
...nd cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strengt... |
C00219 (Arachidonate) C00533 (Nitric oxide) C00641 (1,2-Diacyl-sn-glycerol) C01245 (D-myo-Inositol 1... |
Parallel fiber PLC AMPAR RyR PLA2 PLA2 NOS DAG PLC mGluR1 Glutamate PKC cGMP IGF1R CRFR1 DAG Glutama... |
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hsa04744
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Phototransduction |
Phototransduction is a biochemical process by which the photoreceptor cells generate electrical sign... |
C00076 (Calcium cation) C01330 (Sodium cation) C00942 (3',5'-Cyclic GMP) C00144 (GMP) C00942 (3',5'-... |
PHOTOTRANSDUCTION DARK LIGHT Disc membrane Disc membrane CNG CNG Hyperpolarization (Light response)... |
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hsa05207
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Chemical carcinogenesis - receptor activation |
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stage... |
C00951 (Estradiol-17beta) C00951 (Estradiol-17beta) C00575 (3',5'-Cyclic AMP) C13624 (Bisphenol A) C... |
CHEMICAL CARCINOGENESIS - RECEPTOR ACTIVATION EGFR DNA Ras Raf MEK ERK1/2 DNA PKA pCREB MAPK sig... |
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hsa05208
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Chemical carcinogenesis - reactive oxygen species |
...is well established that cancer is a multi-step process which involves initiation, promotion and pro... |
C10998 (4-Aminobiphenyl) C03622 (N-Hydroxy-4-aminobiphenyl) C06268 (Chromium) C06268 (Chromium) C062... |
CHEMICAL CARCINOGENESIS - REACTIVE OXYGEN SPECIES CYP1A2 4-Aminobiphenyl N-Hydroxy-4-aminobiphe... |
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hsa03015
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mRNA surveillance pathway |
...on elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. |
5976 (UPF1) 26019 (UPF2) 65109 (UPF3B), 65110 (UPF3A) 23049 (SMG1) 23381 (SMG5) 9887 (SMG7) 23293 (S... |
...sm 5'-end capping RNGTT RNMT m7G 3'-end processing Cleavage Poly(A)addition CFIm CPSF CFIIm ... |
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hsa03450
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Non-homologous end-joining |
...recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligas... |
3981 (LIG4) 27343 (POLL) 3981 (LIG4) 1791 (DNTT) 27434 (POLM) 64421 (DCLRE1C) 4361 (MRE11) 10111 (RA... |
...ryotic type Double strand break End binding End processing Gap filling Ligation Mt-Ku Nuclease domai... |
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hsa05014
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Amyotrophic lateral sclerosis |
...in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative ... |
C00025 (L-Glutamate) C00533 (Nitric oxide) C00076 (Calcium cation) C00533 (Nitric oxide) C00062 (L-A... |
...idative phosphorylation PERK IRE1α ATF6 Protein processing in endoplasmic reticulum eIF2α ATF4 p50 A... |
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hsa05163
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Human cytomegalovirus infection |
...n oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one o... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C00584 (Prostaglandin E2) C05981 (Phosphatidylinos... |
...RI FADD Casp8 Fas hCMV PDGFRA MHCI MHCI Antigen processing and presentation Interference with MHC1 a... |
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hsa04145
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Phagocytosis |
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mech... |
C04549 (1-Phosphatidyl-1D-myo-inositol 3-phosphate) C04549 (1-Phosphatidyl-1D-myo-inositol 3-phospha... |
... Toll-like receptor signaling pathway Antigen processing and presentation Sec61 CALR calnexin M... |