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Entry Thumbnail Image Name Description Object Legend
hsa04520 Adherens junction Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important f... ...0 (CSNK2B), 283106 (CSNK2A3) 5795 (PTPRJ) 5777 (PTPN6) 5770 (PTPN1) 5792 (PTPRF) 5787 (PTPRB) 5797 (... Smad4 Cadherin α-Catenin p120ctn p120ctn Cadherin Cadherin Cadherin TCF/LEF NLK TAK1 CBP Smad3 Yes ...
hsa04630 JAK-STAT signaling pathway The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a h... ...51588 (PIAS4), 8554 (PIAS1), 9063 (PIAS2) 5777 (PTPN6) 10254 (STAM2), 8027 (STAM) 3716 (JAK1), 3717 ... c-Myc AKT PI3K SOS GRB CIS Bcl-2 SOCS CBP/P300 IRF9 STAT PIAS SHP1 STAM JAK Ubiquitin mediated prote...
hsa04650 Natural killer cell mediated cytotoxicity Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early def... ...2207 (FCER1G) 7305 (TYROBP) 5781 (PTPN11) 5777 (PTPN6) 3439 (IFNA1), 3440 (IFNA2), 3441 (IFNA4), 344... IgG NFAT CaN PI(3,4,5)P Fyn TRAIL IFNγR PLCγ LAT Perforin HLA-E IFN-γ GM-CSF TNF-α PKC 3BP2 PLC...
hsa04660 T cell receptor signaling pathway Activation of T lymphocytes is a key event for an efficient response of the immune system. It requir... ...CD8B2) 868 (CBLB) 3932 (LCK) 5788 (PTPRC) 5777 (PTPN6) 1493 (CTLA4) 5133 (PDCD1) 5604 (MAP2K1), 5605... PIP DAG CDK4 TNFα GM-CSF IFN-γ IL-10 IL-5 IL-4 IL-2 IκB NFκB IKKβ IKKγ IKKα NIK COT AKT MALT1...
hsa04662 B cell receptor signaling pathway B cells are an important component of adaptive immunity. They produce and secrete millions of differ... ...B) 973 (CD79A) 102723407 (IGH) 6850 (SYK) 5777 (PTPN6) 971 (CD72) 933 (CD22) 102725035, 10288 (LILRB... PIP DAG IκB NFκB IKKβ IKKγ IKKα GSK3β MALT1 BCL-10 CARMA1 AKT PKCβ VAV PI3K CD21 CD19 CD81 LE...
hsa05130 Pathogenic Escherichia coli infection Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic ... ...PK1), 5595 (MAPK3) 2353 (FOS), 3725 (JUN) 5777 (PTPN6), 5781 (PTPN11) 4790 (NFKB1) 10092 (ARPC5), 10... Golgi Regulation of actin cytoskeleton Flagellar assembly Tight junction Toll-like receptor signalin...
hsa05140 Leishmaniasis Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and ... ...FB2), 7043 (TGFB3) 7124 (TNF) 3553 (IL1B) 5777 (PTPN6) 1915 (EEF1A1), 1917 (EEF1A2) 3592 (IL12A), 35... Macrophage FNR FcγR C3b PKC p47phox Complement cascade Leishmania promastigote LPG Calcium sign...
hsa05205 Proteoglycans in cancer Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that... ...K12) 3316 (HSPB2) 3791 (KDR) 7422 (VEGFA) 5777 (PTPN6) 3791 (KDR) 406991 (MIR21) 1499 (CTNNB1) 7448 ... CD44v3 Tiam1 HER2 RhoA ROCK Ankyrin Cytoskeleton activation PI3K AKT CD44 Lipid Raft IP3R CAMKII Fil...
hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer Programmed cell death 1 (PD1) and its ligand (PDL1) are key regulatory physiological immune checkpoi... ... (CD247) 917 (CD3G) 916 (CD3E) 3932 (LCK) 5777 (PTPN6), 5781 (PTPN11) 5133 (PDCD1) 5604 (MAP2K1), 56... PIP IκB NFκB IKK AKT PI3K RasGRP1 Ras AP1 NFAT CaN PLC-γ1 ZAP70 CD3ε CD3δ TCRβ TCRα CD3ζ CD3...

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