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Entry Thumbnail Image Name Description Object Legend
hsa04672 Intestinal immune network for IgA production The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunit... ...Leukocyte transendothelial migration hsa04672: Intestinal immune network for IgA production ...ion Lamina propria Isolated lymphoid follicles INTESTINAL IMMUNE NETWORK FOR IgA PRODUCTION 046...
hsa04930 Type II diabetes mellitus ...istance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha... ...767 (KCNJ11) 6833 (ABCC8) hsa04930: Type II diabetes mellitus hsa04920: Adipocytokine signaling path... ...C INS mTOR MafA GLUT2 Kir6.2 SUR1 TYPE II DIABETES MELLITUS Adipocytokine signaling pathway ...
hsa04940 Type I diabetes mellitus Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-produc... ...receptor signaling pathway hsa04940: Type I diabetes mellitus ... IFNγ IFNγ PRF1 IL-1 TNFα TNFβ TYPE I DIABETES MELLITUS Pancreatic isle Pancreatic lymph node...
hsa04923 Regulation of lipolysis in adipocytes Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and gl... C00575 (3',5'-Cyclic AMP) C00788 (L-Adrenaline) C00547 (L-Noradrenaline) C00942 (3',5'-Cyclic GMP) C... REGULATION OF LIPOLYSIS IN ADIPOCYTES PKA cAMP β-AR Epinephrine HSL Lypolysis Norepinephrine NP...
hsa04950 Maturity onset diabetes of the young ...inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young ... ...UT1) 222546 (RFX6) hsa04950: Maturity onset diabetes of the young hsa04930: Type II diabetes mellitu... ...ax6 Nkx6.1 FoxA2 PDX1 HNF6 MATURITY ONSET DIABETES OF THE YOUNG TypeII Diabetes mellit...
hsa03008 Ribosome biogenesis in eukaryotes ...ories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production an... ...7 (NOB1) hsa03008: Ribosome biogenesis in eukaryotes hsa03010: Ribosome RIBOSOME BIOGENESIS IN EUKARYOTES Pol I Pol III Nucleolus UTP-B complex 18S 5.8S 25S U3 complex...
hsa04261 Adrenergic signaling in cardiomyocytes Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subty... ...GT) hsa04261: Adrenergic signaling in cardiomyocytes hsa04020: Calcium signaling pathway hsa04260: C... ADRENERGIC SIGNALING IN CARDIOMYOCYTES T-tubule Sarcoplasmic Reticulum (SR) DHPR RyR2 NCX NCX SER...
hsa04976 Bile secretion ... of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of el... C01330 (Sodium cation) C00080 (H+) C00698 (Cl-) C00288 (HCO3-) C01353 (Carbonic acid) C00001 (H2O) C... ...Na Cations OA, BA GSH OA, BA SHP OA, BA t-Asbt Intestine Active transport by ileocytes Portal vemous...
hsa04668 TNF signaling pathway ...d in limited cells such as CD4 and CD8 T lymphocytes, endothelial cells, microglia, oligodendrocytes... 7124 (TNF) 7132 (TNFRSF1A) 8717 (TRADD) 7186 (TRAF2), 7188 (TRAF5) 8737 (RIPK1) 329 (BIRC2), 330 (BI... TNF SIGNALING PATHWAY TNF TNFR1 TRADD TRAF2/5 RIP1 cIAP1/2 TAK1 MKK4/7 MKK3/6 p38 JNK1/2 IKKγ IK...
hsa04670 Leukocyte transendothelial migration ...d inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesi... C00027 (Hydrogen peroxide) C00076 (Calcium cation) C00076 (Calcium cation) C00575 (3',5'-Cyclic AMP)... CAMs MMPs CAMs SHP-2 CDH5 CD99 PECAM1 ITGB2 p120ctn p130 AF-6 SPA-1 PECAM1 JAM1 ITGAL CDH5 SHP-2 CD9...
hsa04973 Carbohydrate digestion and absorption ...orous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to... C00092 (D-Glucose 6-phosphate) C00092 (D-Glucose 6-phosphate) C00031 (D-Glucose) C00031 (D-Glucose) ... ...BSORPTION Blood Lumen Salivary secretion Small intestinal epithelial cell Tight junction Tight junct...
hsa04977 Vitamin digestion and absorption ...ey must obtain them from exogenous sources via intestinal absorption. Vitamins are classified based ... C00422 (Triacylglycerol) C02530 (Cholesterol ester) C00422 (Triacylglycerol) C02530 (Cholesterol est... ...ITAMIN DIGESTION AND ABSORPTION Lumen Small intestinal epithelial cell Tight junction Tight junct...
hsa05142 Chagas disease ...matophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host c... C00062 (L-Arginine) C00533 (Nitric oxide) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00076 (Calciu... ...cruzi amastigote Parasitophorous vacuole Tc52 RANTES IκB NFκB IL2 DNA TLR6 CHAGAS DISEASE ACE Inh...
hsa04110 Cell cycle ...l cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcripti... 1029 (CDKN2A) 51343 (FZR1) 4171 (MCM2), 4172 (MCM3), 4173 (MCM4), 4174 (MCM5), 4175 (MCM6), 4176 (MC... ARF Cdh1 MCM ORC APC/C APC/C SCF SCF Orc6 Orc3 Orc5 Orc4 Orc2 Orc1 Mcm7 Mcm6 Mcm5 Mcm4 Mcm3 Mcm2 CDK...
hsa04114 Oocyte meiosis ...regate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (proph... C00410 (Progesterone) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00076 (Calcium cation) C00575 (3'... Mos Cdc2 Mad1/2 CycB2/B5 Myt1 Rsk1/2 p42MAPK MEK1 Progesterone OOCYTE MEIOSIS Early translation of ...
hsa04640 Hematopoietic cell lineage ... lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B l... 102723407 (IGH) 3655 (ITGA6), 3672 (ITGA1), 3673 (ITGA2), 3675 (ITGA3), 3676 (ITGA4), 3678 (ITGA5) 2... IgM CD49 CD42 CD41 CD14 CD9 CD61 IL-11R CD59 CD55 CD35 CD44 CD235a CD36 CD36 CD117 EPOR CD125 CD114 ...
hsa04910 Insulin signaling pathway ...osine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (... C00369 (Starch) C00575 (3',5'-Cyclic AMP) C00031 (D-Glucose) C05981 (Phosphatidylinositol-3,4,5-tris... TSC1 SKIP SHIP2 IKK JNK LAR PTP1B SOCS Elk1 MNK ERK1/2 FAS AMPK Glycogen cAMP INS Glucose HSL PP1 PY...
hsa05146 Amoebiasis ... parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion ... ...Toll-like receptor signaling pathway hsa04672: Intestinal immune network for IgA production hsa04210... Extracellular matrix Intestinal epithelial cell Entamoeba histolytica trophozoite IL1β MUC2 Lamini...
hsa04974 Protein digestion and absorption ...ng the action of gastric, pancreatic and small intestinal enzymes. The result of this proteolytic ac... C01330 (Sodium cation) C01330 (Sodium cation) C00025 (L-Glutamate), C00049 (L-Aspartate) C00037 (Gly... ... DIGESTION AND ABSORPTION Blood Lumen Small intestinal epithelial cell Tight junction Tight junct...
hsa05418 Fluid shear stress and atherosclerosis ...s a central role in vascular biology and contributes to the progress of atherosclerosis. Sustained l... C16845 (Peroxynitrite) C00533 (Nitric oxide) C00076 (Calcium cation) C00704 (Superoxide) C00533 (Nit... ...ress ICAM-1 VCAM-1 E-selectin Adhesion of leukocytes to the endothelium eNOS Caveolae p53 SUMO PIASy...

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