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Thumbnail Image |
Name |
Description |
Object |
Legend |
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hsa00020
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Citrate cycle (TCA cycle) |
...rates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from... |
...xaloacetate) C05379 (Oxalosuccinate) C00024 (Acetyl-CoA) C00149 ((S)-Malate) C00311 (Isocitrate) C00... |
...yruvate Fumarate Oxaloacetate Oxalosuccinate Acetyl-CoA (S)-Malate Isocitrate cis-Aconitate Succinat... |
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hsa01200
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Carbon metabolism |
...ate-hydroxybutyrate cycle, and (6) reductive acetyl-CoA pathway in methanogenic bacteria. |
...-Glycerate) C00168 (Hydroxypyruvate) C00024 (Acetyl-CoA) C05668 (3-Hydroxypropionyl-CoA) C00083 (Mal... |
...osphoserine Serine Glycerate Hydroxypyruvate Acetyl-CoA 3-Hydroxy-propionyl-CoA Malonyl-CoA 3-Hydrox... |
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hsa00010
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Glycolysis / Gluconeogenesis |
...osphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is ... |
...a-Hydroxyethyl)thiamine diphosphate) C00024 (Acetyl-CoA) C00084 (Acetaldehyde) C16255 ([Dihydrolipoy... |
...mide-E Ethanol Pyruvate 2-Hydroxy-ethyl-ThPP Acetyl-CoA Acetaldehyde S-Acetyl-dihydrolipoamide-E Dih... |
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hsa00780
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Biotin metabolism |
...rboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize bioti... |
C02656 (Pimelate) C01063 (6-Carboxyhexanoyl-CoA) C01092 (8-Amino-7-oxononanoate) C01909 (Dethiobioti... |
Tropane, piperidine and pyridine alkaloid biosynthesis BIOTIN METABOLISM Lysine degradation Pimelat... |
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hsa01210
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2-Oxocarboxylic acid metabolism |
...odule RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain l... |
C17254 (8-Methylthiooctyl glucosinolate) C17232 (2-Oxo-10-methylthiodecanoic acid) C17252 (7-Methylt... |
8-Methylthiooctyl glucosinolate 2-Oxo-10-methylthio-decanoic acid 7-Methylthioheptyl glucosinolate 2... |
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hsa01100
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Metabolic pathways |
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... semialdehyde) C19975 (2-Oxepin-2(3H)-ylideneacetyl-CoA) C20062 (2-(1,2-Epoxy-1,2-dihydrophenyl)acet... |
Starch and sucrose metabolism Biosynthesis of enediyne antibiotics Flavonoid biosynthesis Toluene de... |
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hsa00360
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Phenylalanine metabolism |
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...1,9-dioate) C00042 (Succinate) C00582 (Phenylacetyl-CoA) C05593 (3-Hydroxyphenylacetate) C02505 (2-P... |
...xonona-2,4-diene-1,9-dioate Succinate Phenyl-acetyl-CoA 3-Hydroxy-phenylacetate 2-Phenyl-acetamide 4... |
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hsa00061
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Fatty acid biosynthesis |
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...ecanoic acid) C06423 (Octanoic acid) C00024 (Acetyl-CoA) C00083 (Malonyl-CoA) C01209 (Malonyl-[acyl-... |
... Fas FAS1 FASN 6.4.1.2 β-Alanine metabolism Acetyl-CoA Malonyl-CoA Malonyl-[acp] Acetyl-[acp] Aceto... |
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hsa01212
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Fatty acid metabolism |
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C00024 (Acetyl-CoA) C03939 (Acetyl-[acyl-carrier protein]) C05744 (Acetoacetyl-[acp]) C04618 ((3R)-3... |
FATTY ACID METABOLISM Acetyl-CoA Acetyl-[acp] Acetoacetyl-[acp] (R)-3-Hydroxybutanoyl-[acp] Malony... |
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hsa00280
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Valine, leucine and isoleucine degradation |
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...onyl-CoA) C00164 (Acetoacetate) C00332 (Acetoacetyl-CoA) C00024 (Acetyl-CoA) C00091 (Succinyl-CoA) C... |
...oA 3-Methyl-glutaconyl-CoA Acetoacetate Acetoacetyl-CoA Acetyl-CoA Succinyl-CoA (S)-3-Amino-isobutan... |
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hsa04152
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AMPK signaling pathway |
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through ev... |
...00003 (NAD+) C00076 (Calcium cation) C00024 (Acetyl-CoA) C00083 (Malonyl-CoA) C00040 (Acyl-CoA) C000... |
...AD SIRT1 PGC-1α PGC-1α AdipoR CaMKKβ ACC1 Acetyl-CoA Malonyl-CoA CPT1 Fatty Acyl-CoA Increased FF... |
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hsa04931
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Insulin resistance |
Insulin resistance is a condition where cells become resistant to the effects of insulin. It is ofte... |
...-Acylsphingosine) C00031 (D-Glucose) C00024 (Acetyl-CoA) C00022 (Pyruvate) C00024 (Acetyl-CoA) C0257... |
...tochondria β-oxidation DAG Cer PP2A Glucose Acetyl-CoA pyruvate Acetyl-CoA Acetyl-carnitine +ps +ps... |
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hsa00650
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Butanoate metabolism |
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...xyglutarate) C00026 (2-Oxoglutarate) C00024 (Acetyl-CoA) C00356 ((S)-3-Hydroxy-3-methylglutaryl-CoA)... |
...taryl-CoA 2-Hydroxy-glutarate 2-Oxoglutarate Acetyl-CoA (S)-3-Hydroxy-3-methylglutaryl-CoA Acetoacet... |
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hsa05230
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Central carbon metabolism in cancer |
Malignant transformation of cells requires specific adaptations of cellular metabolism to support gr... |
...C00022 (Pyruvate) C00031 (D-Glucose) C00024 (Acetyl-CoA) C00036 (Oxaloacetate) C00158 (Citrate) C003... |
... addiction Increased glutaminolysis G6PD p53 Acetyl-CoA PKM1 isozyme PKM2 isozyme Isocitrate 2-Oxogl... |
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hsa00062
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Fatty acid elongation |
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C00024 (Acetyl-CoA) C00136 (Butanoyl-CoA) C05270 (Hexanoyl-CoA) C05271 (trans-Hex-2-enoyl-CoA) C0526... |
...4.2.1.74 4.2.1.74 4.2.1.74 1.1.1.35 2.3.1.16 Acetyl-CoA Butanoyl-CoA Hexanoyl-CoA trans-Hex-2-enoyl-... |
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hsa00071
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Fatty acid degradation |
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...oyl-CoA) C00877 (Crotonoyl-CoA) C00332 (Acetoacetyl-CoA) C00136 (Butanoyl-CoA) C00229 (Acyl-carrier ... |
...roxy-butanoyl-CoA trans-But-2-enoyl-CoA Acetoacetyl-CoA Butanoyl-CoA [Acyl-carrier protein] 3-Oxo-he... |
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hsa00310
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Lysine degradation |
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...144 ((S)-3-Hydroxybutanoyl-CoA) C00332 (Acetoacetyl-CoA) C00024 (Acetyl-CoA) C00322 (2-Oxoadipate) C... |
...rotonoyl-CoA (S)-3-Hydroxy-butanoyl-CoA Acetoacetyl-CoA Acetyl-CoA 2-Oxoadipate Glutaryl-CoA Glutara... |
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hsa00380
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Tryptophan metabolism |
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...7,8-Dihydro-7,8-dihydroxykynurenate) C00024 (Acetyl-CoA) C01717 (4-Hydroxy-2-quinolinecarboxylic aci... |
...nurenate 7,8-Dihydro-7,8-dihydroxykynurenate Acetyl-CoA Kynurenate 4-(2-Aminophenyl)-2,4-dioxobutano... |
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hsa00620
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Pyruvate metabolism |
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...8 (Formate) C00149 ((S)-Malate) C00332 (Acetoacetyl-CoA) C00024 (Acetyl-CoA) C00227 (Acetyl phosphat... |
...hylene-dicarboxylate Formate (S)-Malate Acetoacetyl-CoA Acetyl-CoA Acetyl-P Acetyladenylate 3-Carbox... |
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hsa00630
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Glyoxylate and dicarboxylate metabolism |
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...noyl-CoA) C00036 (Oxaloacetate) C00332 (Acetoacetyl-CoA) C03561 ((R)-3-Hydroxybutanoyl-CoA) C00877 (... |
...lycine, serine and threonine metabolism Acetoacetyl-CoA (R)-3-Hydroxy-butanoyl-CoA Crotonoyl-CoA (2S... |