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Entry Thumbnail Image Name Description Object Legend
hsa00020 Citrate cycle (TCA cycle) ...rates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from... ...xaloacetate) C05379 (Oxalosuccinate) C00024 (Acetyl-CoA) C00149 ((S)-Malate) C00311 (Isocitrate) C00... ...yruvate Fumarate Oxaloacetate Oxalosuccinate Acetyl-CoA (S)-Malate Isocitrate cis-Aconitate Succinat...
hsa01200 Carbon metabolism ...ate-hydroxybutyrate cycle, and (6) reductive acetyl-CoA pathway in methanogenic bacteria. ...-Glycerate) C00168 (Hydroxypyruvate) C00024 (Acetyl-CoA) C05668 (3-Hydroxypropionyl-CoA) C00083 (Mal... ...osphoserine Serine Glycerate Hydroxypyruvate Acetyl-CoA 3-Hydroxy-propionyl-CoA Malonyl-CoA 3-Hydrox...
hsa00010 Glycolysis / Gluconeogenesis ...osphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is ... ...a-Hydroxyethyl)thiamine diphosphate) C00024 (Acetyl-CoA) C00084 (Acetaldehyde) C16255 ([Dihydrolipoy... ...mide-E Ethanol Pyruvate 2-Hydroxy-ethyl-ThPP Acetyl-CoA Acetaldehyde S-Acetyl-dihydrolipoamide-E Dih...
hsa00780 Biotin metabolism ...rboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize bioti... C02656 (Pimelate) C01063 (6-Carboxyhexanoyl-CoA) C01092 (8-Amino-7-oxononanoate) C01909 (Dethiobioti... Tropane, piperidine and pyridine alkaloid biosynthesis BIOTIN METABOLISM Lysine degradation Pimelat...
hsa01210 2-Oxocarboxylic acid metabolism ...odule RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain l... C17254 (8-Methylthiooctyl glucosinolate) C17232 (2-Oxo-10-methylthiodecanoic acid) C17252 (7-Methylt... 8-Methylthiooctyl glucosinolate 2-Oxo-10-methylthio-decanoic acid 7-Methylthioheptyl glucosinolate 2...
hsa01100 Metabolic pathways ... semialdehyde) C19975 (2-Oxepin-2(3H)-ylideneacetyl-CoA) C20062 (2-(1,2-Epoxy-1,2-dihydrophenyl)acet... Starch and sucrose metabolism Biosynthesis of enediyne antibiotics Flavonoid biosynthesis Toluene de...
hsa00360 Phenylalanine metabolism ...1,9-dioate) C00042 (Succinate) C00582 (Phenylacetyl-CoA) C05593 (3-Hydroxyphenylacetate) C02505 (2-P... ...xonona-2,4-diene-1,9-dioate Succinate Phenyl-acetyl-CoA 3-Hydroxy-phenylacetate 2-Phenyl-acetamide 4...
hsa00061 Fatty acid biosynthesis ...ecanoic acid) C06423 (Octanoic acid) C00024 (Acetyl-CoA) C00083 (Malonyl-CoA) C01209 (Malonyl-[acyl-... ... Fas FAS1 FASN 6.4.1.2 β-Alanine metabolism Acetyl-CoA Malonyl-CoA Malonyl-[acp] Acetyl-[acp] Aceto...
hsa01212 Fatty acid metabolism C00024 (Acetyl-CoA) C03939 (Acetyl-[acyl-carrier protein]) C05744 (Acetoacetyl-[acp]) C04618 ((3R)-3... FATTY ACID METABOLISM Acetyl-CoA Acetyl-[acp] Acetoacetyl-[acp] (R)-3-Hydroxybutanoyl-[acp] Malony...
hsa00280 Valine, leucine and isoleucine degradation ...onyl-CoA) C00164 (Acetoacetate) C00332 (Acetoacetyl-CoA) C00024 (Acetyl-CoA) C00091 (Succinyl-CoA) C... ...oA 3-Methyl-glutaconyl-CoA Acetoacetate Acetoacetyl-CoA Acetyl-CoA Succinyl-CoA (S)-3-Amino-isobutan...
hsa04152 AMPK signaling pathway AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through ev... ...00003 (NAD+) C00076 (Calcium cation) C00024 (Acetyl-CoA) C00083 (Malonyl-CoA) C00040 (Acyl-CoA) C000... ...AD SIRT1 PGC-1α PGC-1α AdipoR CaMKKβ ACC1 Acetyl-CoA Malonyl-CoA CPT1 Fatty Acyl-CoA Increased FF...
hsa04931 Insulin resistance Insulin resistance is a condition where cells become resistant to the effects of insulin. It is ofte... ...-Acylsphingosine) C00031 (D-Glucose) C00024 (Acetyl-CoA) C00022 (Pyruvate) C00024 (Acetyl-CoA) C0257... ...tochondria β-oxidation DAG Cer PP2A Glucose Acetyl-CoA pyruvate Acetyl-CoA Acetyl-carnitine +ps +ps...
hsa00650 Butanoate metabolism ...xyglutarate) C00026 (2-Oxoglutarate) C00024 (Acetyl-CoA) C00356 ((S)-3-Hydroxy-3-methylglutaryl-CoA)... ...taryl-CoA 2-Hydroxy-glutarate 2-Oxoglutarate Acetyl-CoA (S)-3-Hydroxy-3-methylglutaryl-CoA Acetoacet...
hsa05230 Central carbon metabolism in cancer Malignant transformation of cells requires specific adaptations of cellular metabolism to support gr... ...C00022 (Pyruvate) C00031 (D-Glucose) C00024 (Acetyl-CoA) C00036 (Oxaloacetate) C00158 (Citrate) C003... ... addiction Increased glutaminolysis G6PD p53 Acetyl-CoA PKM1 isozyme PKM2 isozyme Isocitrate 2-Oxogl...
hsa00062 Fatty acid elongation C00024 (Acetyl-CoA) C00136 (Butanoyl-CoA) C05270 (Hexanoyl-CoA) C05271 (trans-Hex-2-enoyl-CoA) C0526... ...4.2.1.74 4.2.1.74 4.2.1.74 1.1.1.35 2.3.1.16 Acetyl-CoA Butanoyl-CoA Hexanoyl-CoA trans-Hex-2-enoyl-...
hsa00071 Fatty acid degradation ...oyl-CoA) C00877 (Crotonoyl-CoA) C00332 (Acetoacetyl-CoA) C00136 (Butanoyl-CoA) C00229 (Acyl-carrier ... ...roxy-butanoyl-CoA trans-But-2-enoyl-CoA Acetoacetyl-CoA Butanoyl-CoA [Acyl-carrier protein] 3-Oxo-he...
hsa00310 Lysine degradation ...144 ((S)-3-Hydroxybutanoyl-CoA) C00332 (Acetoacetyl-CoA) C00024 (Acetyl-CoA) C00322 (2-Oxoadipate) C... ...rotonoyl-CoA (S)-3-Hydroxy-butanoyl-CoA Acetoacetyl-CoA Acetyl-CoA 2-Oxoadipate Glutaryl-CoA Glutara...
hsa00380 Tryptophan metabolism ...7,8-Dihydro-7,8-dihydroxykynurenate) C00024 (Acetyl-CoA) C01717 (4-Hydroxy-2-quinolinecarboxylic aci... ...nurenate 7,8-Dihydro-7,8-dihydroxykynurenate Acetyl-CoA Kynurenate 4-(2-Aminophenyl)-2,4-dioxobutano...
hsa00620 Pyruvate metabolism ...8 (Formate) C00149 ((S)-Malate) C00332 (Acetoacetyl-CoA) C00024 (Acetyl-CoA) C00227 (Acetyl phosphat... ...hylene-dicarboxylate Formate (S)-Malate Acetoacetyl-CoA Acetyl-CoA Acetyl-P Acetyladenylate 3-Carbox...
hsa00630 Glyoxylate and dicarboxylate metabolism ...noyl-CoA) C00036 (Oxaloacetate) C00332 (Acetoacetyl-CoA) C03561 ((R)-3-Hydroxybutanoyl-CoA) C00877 (... ...lycine, serine and threonine metabolism Acetoacetyl-CoA (R)-3-Hydroxy-butanoyl-CoA Crotonoyl-CoA (2S...

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