KEGG Modules

Carbohydrate metabolism
Central carbohydrate metabolism
M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:smaf00010 smaf01200 smaf01100]
M00002 Glycolysis, core module involving three-carbon compounds [PATH:smaf00010 smaf01200 smaf01230 smaf01100]
M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH:smaf00010 smaf00020 smaf01100]
M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:smaf00010 smaf00020 smaf00620 smaf00785 smaf01200 smaf01210 smaf01100]
M00009 Citrate cycle (TCA cycle, Krebs cycle) [PATH:smaf00020 smaf01200 smaf01100]
M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:smaf00020 smaf01200 smaf01210 smaf01230 smaf01100]
M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:smaf00020 smaf01200 smaf01210 smaf01100]
M00004 Pentose phosphate pathway (Pentose phosphate cycle) [PATH:smaf00030 smaf01200 smaf01100 smaf01120]
M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:smaf00030 smaf01200 smaf01100 smaf01120]
M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:smaf00030 smaf01200 smaf01230 smaf01100 smaf01120]
M00005 PRPP biosynthesis, ribose 5P => PRPP [PATH:smaf00030 smaf00230 smaf01200 smaf01230 smaf01100]
M00008 Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:smaf00030 smaf01200 smaf01100 smaf01120]

Other carbohydrate metabolism
M00061 D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P [PATH:smaf00040 smaf00030 smaf01100]
M00632 Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P [PATH:smaf00052 smaf01100]
M00549 Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:smaf00520 smaf01250 smaf01100]
M00554 Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH:smaf00520 smaf00052 smaf01250 smaf01100]
M00909 UDP-N-acetyl-D-glucosamine biosynthesis, prokaryotes, glucose => UDP-GlcNAc [PATH:smaf00520 smaf01250 smaf01100]
M00761 Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N [PATH:smaf00520 smaf01100]
M00012 Glyoxylate cycle [PATH:smaf00630 smaf01200 smaf01100 smaf01110]

Energy metabolism
Carbon fixation
M00168 CAM (Crassulacean acid metabolism), dark [PATH:smaf00620 smaf00710 smaf01200 smaf01100 smaf01120]
M00579 Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate [PATH:smaf00430 smaf00620 smaf00720 smaf01200 smaf01100 smaf01120]

Methane metabolism
Nitrogen metabolism
M00531 Assimilatory nitrate reduction, nitrate => ammonia [PATH:smaf00910 smaf01100 smaf01120]
M00530 Dissimilatory nitrate reduction, nitrate => ammonia [PATH:smaf00910 smaf01100 smaf01120]

Sulfur metabolism
M00176 Assimilatory sulfate reduction, sulfate => H2S [PATH:smaf00920 smaf01100 smaf01120]

Photosynthesis
ATP synthesis
M00144 NADH:quinone oxidoreductase, prokaryotes [PATH:smaf00190 smaf01100]
M00149 Succinate dehydrogenase, prokaryotes [PATH:smaf00190 smaf01100]
M00150 Fumarate reductase, prokaryotes [PATH:smaf00190 smaf01100]
M00153 Cytochrome bd ubiquinol oxidase [PATH:smaf00190]
M00417 Cytochrome o ubiquinol oxidase [PATH:smaf00190 smaf01100]
M00157 F-type ATPase, prokaryotes and chloroplasts [PATH:smaf00190 smaf01100]

Lipid metabolism
Fatty acid metabolism
M00082 Fatty acid biosynthesis, initiation [PATH:smaf00061 smaf01212 smaf01100]
M00083 Fatty acid biosynthesis, elongation [PATH:smaf00061 smaf01212 smaf01100]
M00086 beta-Oxidation, acyl-CoA synthesis [PATH:smaf00061 smaf00071 smaf01212 smaf01100]
M00087 beta-Oxidation [PATH:smaf00071 smaf01212 smaf01100]

Sterol biosynthesis
Lipid metabolism
M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:smaf00564 smaf01100]

Nucleotide metabolism
Purine metabolism
M00048 De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:smaf00230 smaf01100]
M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:smaf00230 smaf01232 smaf01240 smaf01100]
M00050 Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:smaf00230 smaf01232 smaf01100]
M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:smaf00230 smaf00240 smaf01232 smaf01100]
M00958 Adenine ribonucleotide degradation, AMP => Urate [PATH:smaf00230 smaf01232 smaf01100]
M00959 Guanine ribonucleotide degradation, GMP => Urate [PATH:smaf00230 smaf01232 smaf01100]

Pyrimidine metabolism
M00051 De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:smaf00240 smaf01240 smaf01100]
M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:smaf00240 smaf01232 smaf01240 smaf01100]
M00938 Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:smaf00240 smaf01232 smaf01100]

Amino acid metabolism
Serine and threonine metabolism
M00020 Serine biosynthesis, glycerate-3P => serine [PATH:smaf00260 smaf00680 smaf01200 smaf01230 smaf01100]
M00018 Threonine biosynthesis, aspartate => homoserine => threonine [PATH:smaf00260 smaf01230 smaf01100 smaf01110]
M00621 Glycine cleavage system [PATH:smaf00260 smaf00630 smaf00785 smaf01200 smaf01100]
M00555 Betaine biosynthesis, choline => betaine [PATH:smaf00260 smaf01100]
M00975 Betaine degradation, bacteria, betaine => pyruvate [PATH:smaf00260 smaf01100]
M00919 Ectoine degradation, ectoine => aspartate [PATH:smaf00260 smaf01100 smaf01120]

Cysteine and methionine metabolism
M00021 Cysteine biosynthesis, serine => cysteine [PATH:smaf00270 smaf00920 smaf01200 smaf01230 smaf01100 smaf01110]
M00338 Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:smaf00260 smaf00270 smaf01230 smaf01100]
M00034 Methionine salvage pathway [PATH:smaf00270 smaf01100]

Branched-chain amino acid metabolism
M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:smaf00290 smaf00770 smaf01210 smaf01230 smaf01100 smaf01110]
M00570 Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:smaf00290 smaf01230 smaf01100]
M00432 Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:smaf00290 smaf01210 smaf01230 smaf01100 smaf01110]

Lysine metabolism
M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:smaf00300 smaf01230 smaf01100]

Arginine and proline metabolism
M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:smaf00220 smaf01210 smaf01230 smaf01100]
M00844 Arginine biosynthesis, ornithine => arginine [PATH:smaf00220 smaf01230 smaf01100]
M00015 Proline biosynthesis, glutamate => proline [PATH:smaf00330 smaf01230 smaf01100]
M00970 Proline degradation, proline => glutamate [PATH:smaf00330 smaf01100]
M00879 Arginine succinyltransferase pathway, arginine => glutamate [PATH:smaf00330 smaf01100]

Polyamine biosynthesis
M00133 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:smaf00330 smaf01100]
M00136 GABA biosynthesis, prokaryotes, putrescine => GABA [PATH:smaf00330 smaf01100]

Histidine metabolism
M00026 Histidine biosynthesis, PRPP => histidine [PATH:smaf00340 smaf01230 smaf01100 smaf01110]
M00045 Histidine degradation, histidine => N-formiminoglutamate => glutamate [PATH:smaf00340 smaf01100]

Aromatic amino acid metabolism
M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:smaf00400 smaf01230 smaf01100 smaf01110]
M00023 Tryptophan biosynthesis, chorismate => tryptophan [PATH:smaf00400 smaf01230 smaf01100 smaf01110]
M00024 Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine [PATH:smaf00400 smaf01230 smaf01100 smaf01110]
M00025 Tyrosine biosynthesis, chorismate => HPP => tyrosine [PATH:smaf00400 smaf01230 smaf01100]
M00533 Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:smaf00350 smaf01220 smaf01100 smaf01120]

Other amino acid metabolism
M00118 Glutathione biosynthesis, glutamate => glutathione [PATH:smaf00480 smaf01240 smaf01100]
M00948 Hydroxyproline degradation, trans-4-hydroxy-L-proline => 2-oxoglutarate [PATH:smaf00470 smaf01100]

Glycan metabolism
Glycan biosynthesis
Glycosaminoglycan metabolism
Lipopolysaccharide metabolism
M00060 KDO2-lipid A biosynthesis, Raetz pathway, LpxL-LpxM type [PATH:smaf00540 smaf01100]
M00063 CMP-KDO biosynthesis [PATH:smaf00540 smaf01250 smaf01100]
M00064 ADP-L-glycero-D-manno-heptose biosynthesis [PATH:smaf00540 smaf01250 smaf01100]

Other polysaccharide metabolism
Metabolism of cofactors and vitamins
Cofactor and vitamin metabolism
M00127 Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:smaf00730 smaf01240 smaf01100]
M00899 Thiamine salvage pathway, HMP/HET => TMP [PATH:smaf00730 smaf01100]
M00125 Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD [PATH:smaf00740 smaf01240 smaf01100 smaf01110]
M00124 Pyridoxal-P biosynthesis, erythrose-4P => pyridoxal-P [PATH:smaf00750 smaf01240 smaf01100]
M00115 NAD biosynthesis, aspartate => quinolinate => NAD [PATH:smaf00760 smaf01240 smaf01100]
M00119 Pantothenate biosynthesis, valine/L-aspartate => pantothenate [PATH:smaf00770 smaf01240 smaf01100 smaf01110]
M00120 Coenzyme A biosynthesis, pantothenate => CoA [PATH:smaf00770 smaf01240 smaf01100]
M00123 Biotin biosynthesis, pimeloyl-ACP/CoA => biotin [PATH:smaf00780 smaf01240 smaf01100]
M00881 Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H [PATH:smaf00785 smaf01240 smaf01100]
M00126 Tetrahydrofolate biosynthesis, GTP => THF [PATH:smaf00790 smaf00670 smaf01240 smaf01100]
M00880 Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:smaf00790 smaf01240 smaf01100]
M00846 Siroheme biosynthesis, glutamyl-tRNA => siroheme [PATH:smaf00860 smaf01240 smaf01100 smaf01110]
M00121 Heme biosynthesis, plants and bacteria, glutamate => heme [PATH:smaf00860 smaf01240 smaf01100 smaf01110]
M00117 Ubiquinone biosynthesis, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol [PATH:smaf00130 smaf01240 smaf01100 smaf01110]
M00116 Menaquinone biosynthesis, chorismate (+ polyprenyl-PP) => menaquinol [PATH:smaf00130 smaf01240 smaf01100 smaf01110]

Biosynthesis of terpenoids and polyketides
Terpenoid backbone biosynthesis
M00096 C5 isoprenoid biosynthesis, non-mevalonate pathway [PATH:smaf00900 smaf01100 smaf01110]
M00364 C10-C20 isoprenoid biosynthesis, bacteria [PATH:smaf00900 smaf01100 smaf01110]

Plant terpenoid biosynthesis
Macrolide biosynthesis
Enediyne biosynthesis
Type II polyketide biosynthesis
Polyketide sugar unit biosynthesis
M00793 dTDP-L-rhamnose biosynthesis [PATH:smaf00521 smaf00523 smaf00541 smaf01250 smaf01100 smaf01110]

Biosynthesis of other secondary metabolites
Biosynthesis of phytochemical compounds
Biosynthesis of beta-lactams
Biosynthesis of other antibiotics
Biosynthesis of other fungal compounds
Biosynthesis of other bacterial compounds
M00790 Pyrrolnitrin biosynthesis, tryptophan => pyrrolnitrin [PATH:smaf00404 smaf01100 smaf01110]
M00918 Aerobactin biosynthesis, lysine => aerobactin [PATH:smaf00997 smaf01100 smaf01110]

Xenobiotics biodegradation
Aromatics degradation
M00551 Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:smaf00362 smaf00622 smaf01220 smaf01100 smaf01120]
M00568 Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:smaf00362 smaf01220 smaf01100 smaf01120]
M00878 Phenylacetate degradation, phenylaxetate => acetyl-CoA/succinyl-CoA [PATH:smaf00360 smaf01100 smaf01120]

Gene set
Pathogenicity
Drug resistance
Plant pathogenicity
Symbiosis
Module set
Metabolic capacity
M00615 Nitrate assimilation
M00616 Sulfate-sulfur assimilation