KEGG    2-Oxocarboxylic acid metabolism - Kocuria indica
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2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
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Module
  • Pathway modules
    • Carbohydrate metabolism
      • Central carbohydrate metabolism
        • M00010 Citrate cycle, first carbon oxidation
    • Energy metabolism
      • Methane metabolism
        • M00608 2-Oxocarboxylic acid chain extension
    • Amino acid metabolism
      • Serine and threonine metabolism
      • Branched-chain amino acid metabolism
        • M00019 Valine/isoleucine biosynthesis
        • M00535 Isoleucine biosynthesis
        • M00432 Leucine biosynthesis
      • Lysine metabolism
        • M00433 Lysine biosynthesis
        • M00031 Lysine biosynthesis, mediated by LysW
      • Arginine and proline metabolism
        • M00028 Ornithine biosynthesis
        • M00763 Ornithine biosynthesis, mediated by LysW
    • Biosynthesis of other secondary metabolites
      • Biosynthesis of phytochemical compounds
        • M00370 Glucosinolate biosynthesis
Reaction module
  • Reaction modules
    • Carboxylic acid metabolism
      • 2-Oxocarboxylic acid chain extension
        • RM001 2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
      • 2-Oxocarboxylic acid chain modification
        • RM002 Carboxyl to amino conversion using protective N-acetyl group (basic amino acid synthesis)
        • RM032 Carboxyl to amino conversion without using protective group
        • RM033 Branched-chain addition (branched-chain amino acid synthesis)
        • RM030 Glucosinolate synthesis
        • RM901 Reductive amination of 2-oxocarboxylic acid (aminotransferase reaction)