KEGG    Primary bile acid biosynthesis
[ Pathway menu | Organism menu | Pathway entry | Download KGML | Show description | Image (png) file ]
Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine.
Scale: 100%
  • Pathway modules
    • Lipid metabolism
      • Sterol biosynthesis
        • M00104 Bile acid biosynthesis
        • M00106 Conjugated bile acid biosynthesis
        • M00862 beta-Oxidation, peroxisome