KEGG    2-Oxocarboxylic acid metabolism - Reference pathway Help
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2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
  • Pathway module
    • Carbohydrate metabolism 
      • Central carbohydrate metabolism 
        • M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
    • Energy metabolism 
      • Methane metabolism 
        • M00608 2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
    • Amino acid metabolism 
      • Serine and threonine metabolism 
        • M00033 Ectoine biosynthesis, aspartate => ectoine
      • Branched-chain amino acid metabolism 
        • M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine
        • M00535 Isoleucine biosynthesis, pyruvate => 2-oxobutanoate
        • M00432 Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
      • Lysine metabolism 
        • M00433 Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
        • M00031 Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine
      • Arginine and proline metabolism 
        • M00028 Ornithine biosynthesis, glutamate => ornithine
        • M00763 Ornithine biosynthesis, mediated by LysW, glutamate => ornithine
    • Biosynthesis of other secondary metabolites 
      • Biosynthesis of other secondary metabolites 
        • M00370 Glucosinolate biosynthesis, tryptophan => glucobrassicin
      • Signature modules 

  • Reaction module
    • Reaction modules 
      • Carboxylic acid metabolism 
        • 2-Oxocarboxylic acid chain extension 
          • RM001 2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
        • 2-Oxocarboxylic acid chain modification 
          • RM002 Carboxyl to amino conversion using protective N-acetyl group (basic amino acid synthesis)
          • RM032 Carboxyl to amino conversion without using protective group
          • RM033 Branched-chain addition (branched-chain amino acid synthesis)
          • RM030 Glucosinolate synthesis
          • RM901 Reductive amination of 2-oxocarboxylic acid (aminotransferase reaction)
        • Fatty acid synthesis and degradation 
        • Acyl-CoA metabolism 
        • Methyl to carboxyl conversion on aromatic ring 
        • Dihydroxylation of aromatic ring 
        • Cleavage of aromatic ring 
        • Dihydroxylation and cleavage of aromatic ring 
        • Amino acid metabolism 
        • Nucleotide metabolism 
        • Sugar metabolism 
        • Aromatics metabolism 
        • Polyketide biosynthesis