KEGG    Cysteine and methionine metabolism - Roseovarius sp. THAF27
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Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
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  • Pathway modules
    • Amino acid metabolism
      • Cysteine and methionine metabolism
        • M00021 Cysteine biosynthesis
        • M00338 Cysteine biosynthesis
        • M00609 Cysteine biosynthesis
        • M00017 Methionine biosynthesis
        • M00034 Methionine salvage pathway
        • M00035 Methionine degradation
        • M00368 Ethylene biosynthesis