KEGG    Pentose phosphate pathway - Streptococcus agalactiae ILRI005
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The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
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  • Pathway modules
    • Carbohydrate metabolism
      • Central carbohydrate metabolism
        • M00004 Pentose phosphate pathway (Pentose phosphate cycle)
        • M00006 Pentose phosphate pathway, oxidative phase
        • M00007 Pentose phosphate pathway, non-oxidative phase
        • M00580 Pentose phosphate pathway, archaea
        • M00005 PRPP biosynthesis
        • M00008 Entner-Doudoroff pathway
        • M00308 Semi-phosphorylative Entner-Doudoroff pathway
        • M00633 Semi-phosphorylative Entner-Doudoroff pathway
        • M00309 Non-phosphorylative Entner-Doudoroff pathway
      • Other carbohydrate metabolism
        • M00631 D-Galacturonate degradation (bacteria)
        • M00061 D-Glucuronate degradation
    • Energy metabolism
      • Methane metabolism
        • M00345 Formaldehyde assimilation, ribulose monophosphate pathway