KEGG Annotation: Enzymes of 2-oxocarboxylic acid metabolism

Enzymes of 2-oxocarboxylic acid metabolism

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2-Oxoacid chain elongation

MT	OT	RM	Module	Pathway	Synthase 2.3.3	Hydratase 4.2.1		Dehydrogenase 1.1.1
MT	OT	RM001	M00010	oxaloacetate => 2-oxoglutarate	K01647 CS, gltA	K01681 ACO, acnA K01682 acnB		K00031 IDH1, icd K00030 IDH3
	OT	RM001	M00433	2-oxoglutarate => 2-oxoadipate (yeast)	K01655 LYS21	K17450 ACO2	K01705 LYS4	K05824 LYS12
	OT	RM001	M00433	2-oxoglutarate => 2-oxoadipate (bacteria)	K01655 LYS21	K16792 aksD	K16793 aksE	K05824 LYS12
	OT	RM001	M00608	2-oxoglutarate => 2-oxoadipate (archaea) 2-oxoadipate => 2-oxopimelate 2-oxopimelate => 2-oxosuberate	K10977 aksA	K16792 aksD	K16793 aksE	K10978 aksF
	OT	RM001	M00535	pyruvate => 2-oxobutanoate	K09011 cimA	K01703 leuC	K01704 leuD	K00052 leuB
	OT	RM001	M00432	2-oxoisovalerate => 2-oxoisocaproate	K01649 leuA	K01703 leuC	K01704 leuD	K00052 leuB
	OT	RM001	M00432	2-oxoisovalerate => 2-oxoisocaproate	K01649 leuA	K01702 LEU1		K00052 leuB

Reaction module
RM001	2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway

			2.3.3 RC00067		4.2.1 RC00497		1.1.1 RC00114
2-oxocarboxylic acid (n)	+	acetyl-CoA	→		→		→	2-oxocarboxylic acid (n+1)

2-Oxoacid oxidizing enzymes

OT	Module	Enzyme	EC	E1		E2	E3	Acceptor
OT	M00307	pyruvate dehydrogenase (acetyl-transferring)	1.2.4.1/2.3.1.12/ 1.8.1.4 (1.2.1.51)	K00161 pdhA	K00162 pdhB	K00627 pdhC	K00382 lpd	NAD(P)+
				K00163 aceE
	M00011	2-oxoglutarate dehydrogenase (succinyl-transferring)	1.2.4.2/2.3.1.61/ 1.8.1.4 (1.2.1.52)	K00164 sucA		K00658 sucB		NAD(P)+
	M00036	2-oxoisovalerate dehydrogenase (2-methylpropanoyl-transferring)	1.2.4.4/2.3.1.168/ 1.8.1.4 (1.2.1.25)	K00166 bkdA1	K00167 bkdA2	K09699 bkdB		NAD+
				K11381 bkdA

OT	Module	Enzyme	EC	alpha	beta	delta	gamma	epsilon	Acceptor
OT	M00307	pyruvate:ferredoxin oxidoreductase	1.2.7.1	K00169 porA	K00170 porB	K00171 porD	K00172 porC		ferredoxin
	M00307	pyruvate:ferredoxin oxidoreductase	1.2.7.1	K03737 por					ferredoxin
	M00011	2-oxoglutarate:ferredoxin oxidoreductase	1.2.7.3	K00174 korA	K00175 korB	K00176 korD	K00177 korC		ferredoxin
	M00011	2-oxoacid:ferredoxin oxidoreductase	1.2.7.11	K00174 oforA	K00175 oforB				ferredoxin
		2-oxoisovalerate:ferredoxin oxidoreductase	1.2.7.7	K00186 vorA	K00187 vorB	K00188 vorD	K00189 vorC		ferredoxin
OT		indolepyruvate:ferredoxin oxidoreductase	1.2.7.8	K00179 iorA	K00180 iorB				ferredoxin
OT		indolepyruvate:ferredoxin oxidoreductase	1.2.7.8	K04090					ferredoxin
OT		phenylglyoxylate:NAD+ oxidoreductase	1.2.1.58	K18355 padG	K18356 padI	K18357 padE	K18358 padF	K18359 padH	NAD+

Reaction class similarity group
RM903	Oxidative decarboxylation of 2-oxoacid to form its CoA derivative

C00022

pyruvate

C00024

acetyl-CoA

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Last updated: November 25, 2015