Select brite hierarchy:    (Brite hierarchy file ID, such as br08303)

Enter relations of objects and attributes:
One-to-one example:

br08303 + Drug to target

One-to-many example:

br08401 + Disease to genome
Alternatively, enter the file name containing the data:

Operation: Add column (one-to-one) Add hierarchy level (one-to-many)

Join Brite is a third type of BRITE mapping (ontology enrichment) tool, which may be viewed as adding a new column (instead of adding color) to the existing BRITE functional hierarchy file. This is done by combining a BRITE file with a binary (or higher) relation file consisting of objects (such as drugs) and attributes (such as their targets), which is similar to the JOIN operation in relational database except that the BRITE file contains an additional column specifying the level of hierarchy. The objects are specified by the following KEGG identifiers followed by tab-delimited attributes in a relation file.

Prefix Category KEGG identifier
ko Genes and proteins K number
br Organisms and cells KEGG organism code
br Diseases and drugs H/D/E numbers
br Compounds and reactions C/G/R numbers

When the binary relation file consists of one-to-one relationships, the result may be convieniently shown by an additional column to the existing BRITE file. However if it consists of one-to-many relationships, the result may better be viewed and manipulated by showning the relationship in an additional hierarchy to the exisiting BRITE file. See example files for this distinction.

Last updated: July 28, 2014