[ Network menu | Network entry | Help ]

ENTRY	nt06032
Name	Lipoic acid metabolism
Category	Pathway view; Cofactor/vitamin metabolism
Pathway	hsa00785 Lipoic acid metabolism
Module	hsa_M00883 Lipoic acid biosynthesis, animals and bacteria, octanoyl-ACP => dihydrolipoyl-H => dihydrolipoyl-E2
Disease	H02000 Dihydrolipoamide dehydrogenase deficiency
Display	drug-target relation   disease type

N01684    Octanoyl-ACP − LIPT2 ⇉ LIAS → Dihydrolipoyl-H − LIPT1 → Dihydrolipoyl-E2     NELABA     LIPT2*     HGCLAS         LIAS*     LIPT1 deficiency                 LIPT1*   N01610    Dihydrolipoyl-H − DLD → Lipoyl-H N01616    Dihydrolipoyl-E2 − DLD → Lipoyl-E2     DLD deficiency     DLD*   N01603    Pyruvate+Lipoyl-E2 − PDH ⇉ DLAT → AcCoA+Dihydrolipoy.. N01609    2OG+Lipoyl-E2 − OGDH ⇉ DLST → SucCoA+Dihydrolipo.. N01619    [KIC,KIV,KMV]+Lipo.. − BCKDH ⇉ DBT → [IV-CoA,IB-CoA,2-M.. N01613    Gly+Lipoyl-H − GLDC ⇉ AMT → MTHF+Dihydrolipoyl.. N01686    2-OA+Lipoyl-E2 − DHTKD1 ⇉ DLST → Glutaryl-CoA+Dihyd..

		Disease name	Disease category
NELABA	H02518	Neonatal severe encephalopathy with lactic acidosis and brain abnormalities	Inherited metabolic disorder
HGCLAS	H02438	Hyperglycinemia, lactic acidosis, and seizures	Inherited metabolic disorder
LIPT1 deficiency	H02643	Lipoyltransferase 1 deficiency	Inherited metabolic disorder
DLD deficiency	H02000	Dihydrolipoamide dehydrogenase deficiency	Inherited metabolic disorder