[ Network menu | Network entry | Help ]

ENTRY	nt06168
Name	Herpes simplex virus 1 (HSV-1)
Category	Disease view; Viral infection
Pathway	hsa05168 Herpes simplex virus 1 infection
Genome	T40073
Disease	H00365 Herpes simplex virus infection
Display	drug-target relation   disease type

N00582    IGF1 → IGF1R → PI3K → PIP3 → AKT ⊣ (TSC1+TSC2) ⊣ RHEB → MTOR ⊣ EIF4EBP1 N00583        VP11/12 → PI3K N00584                    US3 ⊣ (TSC1+TSC2) N00435        (TLR1,TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → IKK → NFKBIA → NFKB ⇒ (TNF,IL6,IL12A,IL1.. N00561        ICP0 ⊣ MYD88 N00562                US3 ⊣ (TRAF6+TAK1+TAB2) N00563        TLR3 → TICAM1 → TRAF6 → TAK1 → IKK → NFKBIA → NFKB N00564    US3 ⊣ TLR3 N00469    RNA → RIGI → MAVS → TRAF3 → (TANK+NAP1+SINTBAD.. → (TBK1+IKBKE) → (IRF7,IRF3) ⇒ (IFNA,IFNB1) N00565    US11 ⊣ (RIGI,MDA5) N00566            UL36USP ⊣ TRAF3 N00567                    ICP34.5 ⊣ (TBK1+IKBKE) N00568                        US3 ⊣ IRF3 N00395    DNA → CGAS → cGAMP → STING1 → TBK1 → IRF3 ⇒ (IFNA,IFNB) N00569    UL41 ⊣ CGAS N00570            ICP0 ⊣ STING1 N00515        OAS → 2-5A → RNASEL N00574    US11 ⊣ OAS N00571        EIF2AK2 → EIF2S1 ⊣ EIF2B N00573    US11 ⊣ EIF2AK2 N00572    ICP34.5 = PPP1C ⊣ EIF2S1 N01489    C3 − (C4b+C2a) → C3b → (C4b+C2a+C3b) N00589        GC ⊣ C3b N00150    (IFNA,IFNB1) → (IFNAR1+IFNAR2) → (JAK1,TYK2) → (STAT1+STAT2+IRF9) ⇒ (IRF7,EIF2AK2) N00576    (UL41,UL13) → SOCS3 ⊣ JAK1 N00577        UL41 ⊣ JAK1 N00578            UL41 ⊣ (STAT1+STAT2+IRF9) N00575            ICP27 ⊣ (STAT1+STAT2+IRF9) N00559    TNFSF14 → TNFRSF14 → TRAF2/5 → IKK → NFKBIA → NFKB N00560    GD → TNFRSF14 → TRAF2/5 → IKK → NFKBIA → NFKB ⇒ (BIRC2,BIRC3,NFKB1.. N00363        TAP1/2 = TAPBP = (PDIA3+CALR) → (MHCI+B2M) N00581    ICP47 ⊣ TAP1/2 N00590                CD74 → MHCII N00591            GB ⊣ CD74 N00145    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → FADD → CASP8 → (CASP3,CASP7) N00579                ICP6 ⊣ CASP8 N00146        (FASLG,TNFSF10) → (FAS,TNFRSF10B) → FADD → (CASP8,CASP10) → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00580                                        ICP0 → CASP3 N00098                    (PMAIP1,BBC3,BAD,B.. ⊣ (BCL2,BCL2L1) ⊣ (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00585                US3 ⊣ BAD N00586        SRPK1 → SRSF1 = NXF1 N00587    ICP27 ⊣ SRPK1 → SRSF1 = NXF1 N00592    ICP0 ⊣ TP53 N00588    (VP16+HCF+POU2F1) ⇒ (ICP0,ICP4,ICP22,I..