TNF signaling |
N00151 |
TNF | → | TNFRSF1A | → | (RIPK1+TRADD+TRAF2.. | → | (TAB1/2/3+TAK1) | → | IKK | → | NFKBIA | → | NFKB |
N00944 |
OspI | ⊣ | UBC13 | → | TRAF2 |
N00945 |
IpaH1.4/2.5 | ⊣ | RFN31 | → | RIPK1 |
N00927 |
| | | | NleE | ⊣ | (TAB2/3) |
N00942 |
| | | | | | OspG | ⊣ | (UBE2D2+(RBX1+CUL1.. | → | NFKBIA |
N00943 |
| | | | | | | | | | IpaH4.5 | ⊣ | RELA |
| | |
Autophagy |
N00156 |
LC3 | − | ATG4 | ⇉ | ATG7 | ⇉ | ATG3 | ⇉ | (ATG12+ATG5+ATG16L.. | → | LC3-II |
N01284 |
| | | | IcsP | ⊣ | C3 | = | ATG16L |
| | |
TLR signaling |
N00438 |
(TLR2,TLR4) | → | (TIRAP+MYD88) | → | (IRAK4+IRAK1) | → | (TRAF6+TAK1+TAB2) | → | (MEK,MKK3/6,MKK4/7.. | → | (ERK,p38,JNK) | → | AP1 |
N01283 |
| | | | | | | | OspF | ⊣ | (ERK,p38) |
| | |
NLR signaling |
N00940 |
(NOD1,NOD2) | → | RIPK2 | → | IKK | → | NFKBIA | → | NFKB |
N00941 |
| | (IpaH9.8+TNIP1) | ⊣ | IKBKG |
N00742 |
| | | | (NLRP3+PYCARD) | → | CASP1 | → | (IL1B,IL18,IL33) |
N00948 |
IpaH7.8 | ⊣ | GLMN | ⊣ | (NLRP3+PYCARD) | → | CASP1 | → | IL1B |
N00867 |
| | | | (NLRC4+PYCARD) | → | CASP1 | → | (IL1B,IL18) |
N00949 |
IpaB | → | K+ | → | (NLRC4+PYCARD) | → | CASP1 | → | IL1B |
| | |
CGAS-STING signaling |
N00395 |
DNA | → | CGAS | → | cGAMP | → | STING1 | → | TBK1 | → | IRF3 | ⇒ | (IFNA,IFNB) |
N00946 |
| | IpaJ | ⊣ | ARF1 | → | STING1 |
N00947 |
| | | | | | Ipa4.5 | ⊣ | TBK1 |
| | |
Cytoskeletal regulation |
N01072 |
FN1 | → | (ITGA+ITGB) | → | PTK2 | → | ARHGEF28 | → | RHOA |
N01074 |
| | | | | | IpaA | → | RHOA | → | ROCK1/2 | → | MLC |
N01073 |
| | | | | | IpgB2 | → | RHOA |
N01075 |
| | | | | | IcsB | ⊣ | RHOA |
N01068 |
FN1 | → | (ITGA+ITGB) | → | (SRC,PTK2) | → | (PXN,CRK+BCAR1) | → | (DOCK1+ELMO1) | → | RAC |
N01069 |
| | | | | | | | IpgB1 | → | RAC1 |
N01077 |
| | | | | | | | IcsB | ⊣ | RAC1 |
N00952 |
| | | | | | IpgB1 | → | (DOCK1+ELMO) | → | RAC1 |
N01070 |
FN1 | → | (ITGA+ITGB) | → | (SRC,PTK2) | → | PXN | → | (GIT2+ARHGEF7) | → | CDC42 |
N01071 |
| | | | | | | | IpgB1 | → | CDC42 |
N01076 |
| | | | | | | | IcsB | ⊣ | CDC42 |
N01066 |
| | | | | | | | ARNO | → | ARF6 | → | ARF1 | → | (WASF+ABI1+HSPC300.. | → | ARP2/3 | → | (ACTB,ACTG1) |
N01067 |
IpgD | → | PI(5)P | → | PI3K | → | PIP3 | → | ARNO | → | ARF6 | → | ARF1 | → | (WASF+ABI1+HSPC300.. | → | ARP2/3 | → | (ACTB,ACTG1) |
N01078 |
EGF | → | EGFR | → | SRC | → | CTTN | → | NCK | → | (WASL+WIPF) | → | ARP2/3 | → | (ACTB,ACTG1) |
N01079 |
| | IpaC | → | SRC | → | CTTN | → | ARP2/3 | → | (ACTB,ACTG1) |
N01080 |
FN1 | → | (ITGA+ITGB) | → | (PTK2+PXN+ILK) | → | (TLN+ACTN1/4+VCN) | → | (ACTB,ACTG1) |
N01081 |
(IpaB+IpaC,IpaD) | → | (ITGA5+ITGB1) | → | (PTK2+PXN) | → | (TLN+VCN) | → | (ACTB,ACTG1) |
N01083 |
| | OspE | ⊣ | (PTK2+PXN+ILK) |
N01082 |
| | | | IpaA | → | (ACTN1/4+VCN) |
|