Network variation - Cell cycle (cancer)
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ENTRY
nt06230
Name
Cell cycle (cancer)
Category
Disease view; Cancer signaling
Display
drug-target relation
disease type
N00066
CDKN2A
⊣
MDM2
⊣
TP53
⇒
CDKN1A
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00067
CDKN2A*
⌿
MDM2
⊣
TP53
⇒
CDKN1A
⊣
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00076
CDKN2A*
⌿
MDM2
⊣
TP53
⇒
CDKN1A
⊣
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00068
MDM2*
⊣
TP53
⇒
CDKN1A
⊣
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00167
(
vIRF1
,
vIRF3
)
⊣
TP53
N00169
LANA
⊣
TP53
N00069
CDKN2A
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00494
TAX
⊣
CDKN2A
N00070
CDKN2A*
⌿
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00071
CDKN2A*
⌿
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00168
vCyclin
→
CDK4/6
→
RB1
⌿
E2F
N00072
(
CCND
+
CDK4*
)
→
RB1
⌿
E2F
N00073
(
CCND
+
CDK4*
)
→
RB1
⌿
E2F
N00275
(
CCND1*
+
CDK4
)
→
RB1
⌿
E2F
N00170
LANA
→
RB1
⌿
E2F
N00074
RB1*
⌿
E2F
N00075
RB1*
⌿
E2F
N00090
(MYC+MAX)
⊣
ZBTB17
⇒
CDKN2B
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00088
(
MYC*
+
MAX
)
⊣
ZBTB17
⇒
CDKN2B
⊣
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00495
TAX
⊣
CDKN2B
N00089
(
MYC*
+
MAX
)
⇒
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00091
(SCF+SKP2)
⊣
CDKN1B
⊣
((CCNA,CCNE)+CDK2)
→
RB1
⌿
E2F
N00092
(
MYC*
+
MAX
)
⇒
CKS1B
→
(
SCF
+
SKP2
)
⊣
CDKN1B
⊣
(
CCNE
+
CDK2
)
→
RB1
⌿
E2F
N00093
CDKN1B*
⌿
(
CCNE
+
CDK2
)
→
RB1
⌿
E2F
N00254
CDKN1B*
⌿
(
CCNE
+
CDK2
)
→
RB1
⌿
E2F
N00255
(
CCNE*
+
CDK2
)
→
RB1
⌿
E2F
N01336
ACh
→
CHRNA7
→
ARRB1
→
SRC
→
RAF1
→
RB1
⌿
E2F1
N01337
(
NNK
,
NNN
)
→
CHRNA7
→
ARRB1
→
SRC
→
RAF1
→
RB1
⌿
E2F1
⇒
(
BIRC5
,
XIAP
,
CDC6
,
C..
N00499
(ATM,ATR)
→
CHEK1
→
TP53
⇒
CDKN1A
⊣
(CDK1+CCNB)
N00500
TAX
⊣
CHEK1
N00493
MAD1L1
→
(MAD2L1/2+BUB1B+BU..
⊣
(ANAPC+CDC20)
⊣
PTTG
⊣
ESPL1
N00222
TAX
⊣
MAD1L1
N00221
TAX
→
(
ANAPC
+
CDC20
)
⊣
PTTG
⊣
ESPL1