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ENTRY	nt06325
Name	Hormone/cytokine signaling
Category	Pathway view; Endocrine system
Display	drug-target relation   disease type

D3,D4  |             N00920    PRL → PRLR → JAK2 → STAT5     HPRL     PRLR*   N01800    LEP → LEPR → JAK2 → STAT3/5     LEPD LEP*     LEPRD     LEPR*   N01788    ADIPOQ → ADIPOR → APPL1     ADPOD ADIPOQ*     MODY14         APPL1*   N01708    INS → INSR → IRS → PI3K     T1D2/MODY10/PNDM4 INS*     DS/RMS/IRAN/HHF5     INSR*     CHNG9         IRS4*   N01783    NPPA → NPR1 → cGMP → PRKG1/2     ATFB6/ATRST2 NPPA*     ATT8             PRKG1*     AMD4/SMDP             PRKG2* N01787    NPPC → NPR2 → cGMP → PRKG1/2     AMD1/SNSK     NPR2*     ECDM     NPR2* ↗         D1,D2  |                     N00915    AVP → AVPR2 → GNAS → ADCY3/6/9 → cAMP → PKA → AQP2     NPDI AVP*     NSIAD     AVPR2* ↗   N00879    PROK1/2 → PROKR1/2 → GNAI → ERK     HH4 PROK2*     HH3     PROKR2*   N01792    EDN1/2/3 → EDNRA/B → GNAQ,GNA11     ARCND3 EDN1*     HSCR4/WS4B EDN3*     MFDA     EDNRA* ↗     HSCR2/WS4A/ABCDS     EDNRB*   N01793    GAL → GALR → GNAO1,GNAI,GNA11/1..     ETL8 GAL*   N01794    HCRT → HCRTR1/2 → GNAQ,GNA11/14/15,G..     NRCLP1 HCRT*   N01823    FGF23 → (FGFR1+KL) → ERK → SGK1 → WNK1/4 → NCC → (Na+,CL-)(cyto) N01824                SGK1 → (NHERF1+NPT) → (Na+,Pi)(cyto)     ADHR FGF23* ↗     HFTC2 FGF23*     HFTC3     KL*     PHA2C                 WNK1* ↗     HSAN2A                 WNK1*     PHA2B                 WNK4* ↗     NPHLOP2                 NHERF1*     NPHLOP1/FRTS2/HCINF2                 SLC34A1*     HHRH                 SLC34A3*     GTLMNS                     SLC12A3*

		Disease name	Disease category
HPRL	H01388	Hyperprolactinemia	Endocrine and metabolic disease
LEPD	H02059	Leptin deficiency	Endocrine and metabolic disease
LEPRD	H02060	Leptin receptor deficiency	Endocrine and metabolic disease
ADPOD	H00967	Adiponectin deficiency	Inherited metabolic disorder
MODY14	H00410	Maturity onset diabetes of the young (MODY)	Endocrine and metabolic disease
T1D2/MODY10/PNDM4	H00408	Type 1 diabetes mellitus	Metabolic disease
	H00410	Maturity onset diabetes of the young (MODY)	Endocrine and metabolic disease
	H00512	Permanent neonatal diabetes mellitus	Endocrine and metabolic disease
DS/RMS/IRAN/HHF5	H00719	Leprechaunism	Endocrine and metabolic disease
	H00942	Rabson-Mendenhall syndrome	Endocrine and metabolic disease
	H01228	Insulin-resistant diabetes mellitus with acanthosis nigricans	Metabolic disease
	H01267	Familial hyperinsulinemic hypoglycemia	Inherited metabolic disorder
CHNG9	H00250	Congenital nongoitrous hypothyroidism (CHNG)	Endocrine and metabolic disease
ATFB6/ATRST2	H00731	Atrial fibrillation	Cardiovascular disease
	H02674	Atrial standstill	Cardiovascular disease
ATT8	H00801	Familial thoracic aortic aneurysm and dissection	Cardiovascular disease
AMD4/SMDP	H02543	Acromesomelic dysplasia	Congenital malformation
	H02185	Spondylometaphyseal dysplasia	Congenital malformation
AMD1/SNSK	H02543	Acromesomelic dysplasia	Congenital malformation
	H02681	Short stature with nonspecific skeletal abnormalities	Congenital malformation
ECDM	H02679	Miura-type epiphyseal chondrodysplasia	Congenital malformation
NPDI	H00253	Neurohypophyseal diabetes insipidus	Endocrine and metabolic disease
NSIAD	H01294	Nephrogenic syndrome of inappropriate antidiuresis	Endocrine and metabolic disease
HH4	H00255	Hypogonadotropic hypogonadism	Endocrine and metabolic disease
HH3	H00255	Hypogonadotropic hypogonadism	Endocrine and metabolic disease
ARCND3	H01884	Auriculocondylar syndrome	Congenital malformation
HSCR4/WS4B	H00910	Hirschsprung disease	Congenital malformation
	H00759	Waardenburg syndrome	Inherited metabolic disorder
MFDA	H02126	Mandibulofacial dysostosis with alopecia	Congenital malformation
HSCR2/WS4A/ABCDS	H00910	Hirschsprung disease	Congenital malformation
	H00759	Waardenburg syndrome	Inherited metabolic disorder
	H00823	ABCD syndrome	Congenital malformation
ETL8	H00809	Familial epilepsy temporal lobe (ETL)	Nervous system disease
NRCLP1	H01293	Narcolepsy	Nervous system disease
ADHR	H00214	Hypophosphatemic rickets	Inherited metabolic disorder
HFTC2	H01193	Familial tumoral calcinosis	Inherited metabolic disorder
HFTC3	H01193	Familial tumoral calcinosis	Inherited metabolic disorder
PHA2C	H00243	Hyperkalemic distal renal tubular acidosis (RTA type 4)	Urinary system disease
HSAN2A	H00265	Hereditary sensory and autonomic neuropathy	Nervous system disease
PHA2B	H00243	Hyperkalemic distal renal tubular acidosis (RTA type 4)	Urinary system disease
NPHLOP2	H00888	Nephrolithiasis/osteoporosis, hypophosphatemic	Urinary system disease
NPHLOP1/FRTS2/HCINF2	H00888	Nephrolithiasis/osteoporosis, hypophosphatemic	Urinary system disease
	H01198	Fanconi renotubular syndrome	Inherited metabolic disorder
	H01371	Hypercalcemia infantile	Inherited metabolic disorder
HHRH	H00214	Hypophosphatemic rickets	Inherited metabolic disorder
GTLMNS	H00240	Gitelman syndrome	Endocrine and metabolic disease

		Drug name
D1	D00101	Vasopressin (JP18/USP)
D2	D02235	Desmopressin acetate (USP)
D3	D00780	Bromocriptine mesylate (USP)
D4	D00987	Cabergoline (JP18/USP/INN)