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ENTRY	nt06461
Name	Huntington disease
Category	Disease view; Neurodegenerative disease
Pathway	hsa05016 Huntington disease
Disease	H00059 Huntington disease
Display	drug-target relation   disease type

Calcium signaling N00984    Glutamate → GRM5 → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00985    Glutamate → GRM5 → GNAQ → PLCB → IP3 → (ITPR+HTT*) → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00967                    Ca2+(extracellular.. − VGCC → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00986                HTT* ⊣ STX1A ⊣ VGCC(N-type) → Ca2+ N00970                    Glutamate → NMDAR → Ca2+ N00987                HTT* ⌿ DLG4 → NMDAR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → CASP3   Ubiquitin-proteasome system N01029    (Protein+UB) − 26S → Peptide N01061    HTT* ⊣ 26S   Autophagy N00155    mTORC1 → ULK1_complex → PI3KC3-C1 N00993        HTT* ⊣ (BECN1+PIK3C3+ATG1..   Apoptosis N00145    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → FADD → CASP8 → (CASP3,CASP7) N00983            HTT* ⌿ (HIP1+IFT57) → CASP8 → CASP3   TNF signaling N00446    TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAK1+TAB1/2) → MKK4/7 → JNK → AP1 N00992            HTT* → MLK2 → MKK7 → JNK   Oxidative phosphorylation N00988    Succinate − CxII → QH2 N00989    HTT* ⊣ CxII → QH2 N00990    QH2 − CxIII → CytC N00991    HTT* ⊣ CxIII → CytC   Microtubule-based transport N00976            (DCTN+DNAH+DNAI+DN.. = (TUBA+TUBB) N00977        (HTT*+HAP1) ⊣ (DCTN+DNAH+DNAI+DN.. = (TUBA+TUBB) N00978            (KIF5+KLC) = (TUBA+TUBB) N00979    HTT* → JNK3 ⊣ (KIF5+KLC) = (TUBA+TUBB)   Transcription N00980    HTT* ⌿ REST = (SIN3A+RCOR1+(HDAC.. ⫤ BDNF N00981    HTT* ⊣ (CREB+TAF4) ⇒ PPARGC1A N00982    HTT* → TP53 ⇒ (BAX,BBC3)