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ENTRY	nt06502
Name	Nucleotide excision repair
Category	Pathway view; Replication and repair
Pathway	hsa03420 Nucleotide excision repair
Disease	H00403 Disorders of nucleotide excision repair
Display	drug-target relation   disease type

N01425    (CRL4+DDB2) = (XPC+RAD23A,RAD23B.. → (XPC+CETN2) = (ERCC3+ERCC2) = (GTF2H) = (CAK)     White-Kernohan syndrome DDB1*     XPE DDB2*     XPC     XPC*     XPB/CS/TTD2             ERCC3*     XPD/TTD1/COFS2             ERCC2*     TTD3                 GTF2H5*   N01430    (POLR2+UVSSA) = (ERCC6+ERCC8+CRL4) → (POLR2+UVSSA+ERCC6.. = (ERCC3+ERCC2) = (GTF2H) = (CAK)     NEDHIB POLR2A*     UVSS3 UVSSA*     CSB/UVSS1/COFS1     ERCC6*     CSA/UVSS2     ERCC8*   N01431    (ERCC3+ERCC2+GTF2H.. = ERCC5 = XPA = RPA → (ERCC1+ERCC4) = XPA = RPA = ERCC5 → PCNA = POLD,POLE,POLK,POL.. → LIG1,(LIG3+XRCC1)     XPG/CS/COFS3     ERCC5*     XPA         XPA*     PFBMFT             RPA1*     XPF/CS/FANCQ                 ERCC4*     COFS4                 ERCC1*     ATLD                                 PCNA*     IMD122                                     POLD3*     XPV                                     POLH*

		Disease name	Disease category
White-Kernohan syndrome	H02560	White-Kernohan syndrome	Congenital malformation
XPE	H01428	Xeroderma pigmentosum	Congenital malformation
XPC	H01428	Xeroderma pigmentosum	Congenital malformation
XPB/CS/TTD2	H01428	Xeroderma pigmentosum	Congenital malformation
	H00076	Cockayne syndrome	Neurodegenerative disease
	H00866	Trichothiodystrophy	Skin disease
XPD/TTD1/COFS2	H01428	Xeroderma pigmentosum	Congenital malformation
	H00866	Trichothiodystrophy	Skin disease
	H02570	Cerebro-oculo-facio-skeletal syndrome	Congenital malformation
TTD3	H00866	Trichothiodystrophy	Skin disease
NEDHIB	H02571	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Nervous system disease
UVSS3	H02131	UV-sensitive syndrome	Skin disease
CSB/UVSS1/COFS1	H00076	Cockayne syndrome	Neurodegenerative disease
	H02131	UV-sensitive syndrome	Skin disease
	H02570	Cerebro-oculo-facio-skeletal syndrome	Congenital malformation
CSA/UVSS2	H00076	Cockayne syndrome	Neurodegenerative disease
	H02131	UV-sensitive syndrome	Skin disease
XPG/CS/COFS3	H01428	Xeroderma pigmentosum	Congenital malformation
	H00076	Cockayne syndrome	Neurodegenerative disease
	H02570	Cerebro-oculo-facio-skeletal syndrome	Congenital malformation
XPA	H01428	Xeroderma pigmentosum	Congenital malformation
PFBMFT	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
XPF/CS/FANCQ	H01428	Xeroderma pigmentosum	Congenital malformation
	H00076	Cockayne syndrome	Neurodegenerative disease
	H00238	Fanconi anemia	Hematologic disease
COFS4	H02570	Cerebro-oculo-facio-skeletal syndrome	Congenital malformation
ATLD	H02014	Ataxia-telangiectasia-like syndrome	Immune system disease
IMD122	H00091	T-B+Severe combined immunodeficiency	Primary immunodeficiency
XPV	H01428	Xeroderma pigmentosum	Congenital malformation