KEGG    Network variation - Telomere length regulation
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ENTRYnt06510
NameTelomere length regulation
CategoryPathway view; Replication and repair
DiseaseH00507 Dyskeratosis congenita
H02569 Pulmonary fibrosis and/or bone marrow failure, telomere-related
H02251 Cerebroretinal microangiopathy with calcifications and cysts
Display drug-target relation   disease type
N01475    TERC+TGS1→TERC+PAPD5→TERC+PARN+ZCCHC8
    DKCA1/PFBMFT2/AA TERC*
    DKCB6/PFBMFT4     PARN*
    PFBMFT5     ZCCHC8*
 
N01476    TERC+TERT+Pontin+R..=DKC1+NOP10+NHP2+GA..→TERC+TERT+Pontin+R..=WRAP53+TriC
    DKCA2/PFBMFT1/AA/CMM9 TERT*
    DKCX   DKC1*
    DKCB1/PFBMFT9   NOP10*
    DKCB2   NHP2*
    PFBMFT7   NAF1*
    DKCB3       WRAP53*
    IDDPMGS       TCP1*
    NEDSVH       CCT3*
    HSNSP       CCT5*
 
N01477    RTEL1+RAP1+TRF2+TI..=telomerase→Shelterin=CTC1+STN1+TEN1
    DKCA4/PFBMFT3 RTEL1*
    DKCA3_A5 TIN2*
    DKCA6_B7 ACD*
    TPDS3/PFBMFT8/CRMCC3 POT1*
    CRMCC1       CTC1*
    CRMCC2       STN1*

Disease nameDisease category
DKCA1/PFBMFT2/AAH00507Dyskeratosis congenitaRibosomopathy
H02569Pulmonary fibrosis and/or bone marrow failure, telomere-relatedHematologic disease
H01132Aplastic anemiaHematologic disease
DKCB6/PFBMFT4H00507Dyskeratosis congenitaRibosomopathy
H02569Pulmonary fibrosis and/or bone marrow failure, telomere-relatedHematologic disease
PFBMFT5H02569Pulmonary fibrosis and/or bone marrow failure, telomere-relatedHematologic disease
DKCA2/PFBMFT1/AA/CMM9H00507Dyskeratosis congenitaRibosomopathy
H02569Pulmonary fibrosis and/or bone marrow failure, telomere-relatedHematologic disease
H01132Aplastic anemiaHematologic disease
H00038MelanomaCancer
DKCXH00507Dyskeratosis congenitaRibosomopathy
DKCB1/PFBMFT9H00507Dyskeratosis congenitaRibosomopathy
H02569Pulmonary fibrosis and/or bone marrow failure, telomere-relatedHematologic disease
DKCB2H00507Dyskeratosis congenitaRibosomopathy
PFBMFT7H02569Pulmonary fibrosis and/or bone marrow failure, telomere-relatedHematologic disease
DKCB3H00507Dyskeratosis congenitaRibosomopathy
IDDPMGSH02843Brain malformations and seizures by impaired function of TRiCCongenital malformation
NEDSVHH02843Brain malformations and seizures by impaired function of TRiCCongenital malformation
HSNSPH02580Hereditary sensory neuropathy with spastic paraplegiaNervous system disease
DKCA4/PFBMFT3H00507Dyskeratosis congenitaRibosomopathy
H02569Pulmonary fibrosis and/or bone marrow failure, telomere-relatedHematologic disease
DKCA3_A5H00507Dyskeratosis congenitaRibosomopathy
DKCA6_B7H00507Dyskeratosis congenitaRibosomopathy
TPDS3/PFBMFT8/CRMCC3H02624Tumor predisposition syndromeCancer
H02569Pulmonary fibrosis and/or bone marrow failure, telomere-relatedHematologic disease
H02251Cerebroretinal microangiopathy with calcifications and cystsNervous system disease
CRMCC1H02251Cerebroretinal microangiopathy with calcifications and cystsNervous system disease
CRMCC2H02251Cerebroretinal microangiopathy with calcifications and cystsNervous system disease