[ Network menu | Network entry | Help ]

ENTRY	nt06512
Name	Chromosome cohesion and segregation
Category	Pathway view; Cellular process
Pathway	hsa04110 Cell cycle
Disease	H00631 Cornelia de Lange syndrome H00773 Autosomal dominant intellectual developmental disorder H02632 PP2A-related neurodevelopmental disorder H00269 Primary microcephaly
Display	drug-target relation   disease type

N01482    Cohesin → ATRX = Cohesin = NIPBL+MAU2 → DDX11 = Cohesin+NIPBL+MAU2     CDLS2/DEE85 SMC1*     CDLS3 SMC3*     CDLS4 RAD21*     MRD47 STAG1*     HPE13/MKMS STAG2*     ATRX/MRXHF1     ATRX*     CDLS1             NIPBL*     WABS                 DDX11*   N01813        H3K27ac = BRD4 = NIPBL     CDLS6         BRD4*   N01483                HDAC8 ⊣ ESCO1,ESCO2 − SMC3 → CDCA5     RBS/JHS                 ESCO2*     CDLS5             HDAC8*   N01484            STAG1,STAG2 = PDS5+WAPL → CDCA5,CTCF = STAG+PDS5+WAPL     MRD21                 CTCF*   N01485                SGO1+PP2A ⊣ PLK1,AURKB,CDK1 − STAG+CDCA5     CAID             SGO1*     NEDLBA             PPP2CA*     MRD36             PPP2R1A*     SCLC/NSCLC             PPP2R1B*     MRD35             PPP2R5D*   N01486            ANAPC+CDC20 ⊣ PTTG1 ⊣ ESPL1 ⊣ RAD21     RTS1         ANAPC1*     FERBON         ANAPC7*   N01497                    PP2A = Condensin_II → TOP2A+KIF4A+DNMT3B = Condensin_I     MCPH22                     NCAPD3*     3KS                     NCAPG2*     XLID100                         KIF4A*     ICF1/FSHD4                         DNMT3B*     MCPH23                             NCAPH*     MCPH21                             NCAPD2*   N01498                    MCPH1 → NCAPG2 ⌿ SMC2     MCPH1                 MCPH1*   N01499                    PLK1,AURKB,CDK1 − NCAPD3,NCAPG2,NCAP.. N01500                            AURKB,CDK1 − NCAPD2,NCAPG,NCAPH N01501                            CK2 ⊣ SMC4,NCAPD2,NCAPG,..     OCNDS                         CSNK2A1*

		Disease name	Disease category
CDLS2/DEE85	H00631	Cornelia de Lange syndrome	Congenital malformation
	H00606	Early infantile epileptic encephalopathy	Nervous system disease
CDLS3	H00631	Cornelia de Lange syndrome	Congenital malformation
CDLS4	H00631	Cornelia de Lange syndrome	Congenital malformation
MRD47	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
HPE13/MKMS	H00267	Holoprosencephaly	Congenital malformation
	H02582	Mullegama-Klein-Martinez syndrome	Congenital malformation
ATRX/MRXHF1	H01752	ATR-X syndrome	Congenital malformation
	H02583	X-linked intellectual disability-hypotonic facies syndrome	Congenital malformation
CDLS1	H00631	Cornelia de Lange syndrome	Congenital malformation
WABS	H00914	Warsaw breakage syndrome	Congenital malformation
CDLS6	H00631	Cornelia de Lange syndrome	Congenital malformation
RBS/JHS	H00572	Roberts-SC phocomelia syndrome	Congenital malformation
	H02581	Juberg-Hayward syndrome	Congenital malformation
CDLS5	H00631	Cornelia de Lange syndrome	Congenital malformation
MRD21	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
CAID	H02122	Chronic atrial and intestinal dysrhythmia	Cardiovascular disease
NEDLBA	H02632	Houge-Janssens syndrome	Congenital malformation
MRD36	H02632	Houge-Janssens syndrome	Congenital malformation
	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
SCLC/NSCLC	H00013	Small cell lung cancer	Cancer
	H00014	Non-small cell lung cancer	Cancer
MRD35	H02632	Houge-Janssens syndrome	Congenital malformation
	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
RTS1	H01734	Rothmund-Thomson syndrome	Congenital malformation
FERBON	H02584	Ferguson-Bonni neurodevelopmental syndrome	Congenital malformation
MCPH22	H00269	Primary microcephaly	Congenital malformation
3KS	H02707	Khan-Khan-Katsanis syndrome	Congenital malformation
XLID100	H00480	X-linked intellectual developmental disorder	Mental and behavioural disorder
ICF1/FSHD4	H02308	Immunodeficiency-centromeric instability-facial anomalies syndrome	Immune system disease
	H00591	Facioscapulohumeral muscular dystrophy	Nervous system disease
MCPH23	H00269	Primary microcephaly	Congenital malformation
MCPH21	H00269	Primary microcephaly	Congenital malformation
MCPH1	H00269	Primary microcephaly	Congenital malformation
OCNDS	H02460	Neurodevelopmental disorder with dysmorphic facies and skeletal anomalies	Congenital malformation