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ENTRY	nt06513
Name	Complement cascade
Category	Pathway view; Immune system
Pathway	hsa04610 Complement and coagulation cascades
Disease	H00102 Classic complement pathway component defects H00105 Mannose-binding lectin pathway component defects H00104 Alternative complement pathway component defects H00103 Late complement pathway defects H00106 Complement regulatory protein defects
Display	drug-target relation   disease type

N01487        C4a deficiency     C4b deficiency     C2 deficiency/ARMD14     C1qa deficiency     C1qb deficiency     C1qc deficiency     C1r deficiency/EDSPD1     C1s deficiency/EDSPD2 N01314    SARS-CoV-2 N00213    KSHV   N01491        LCAPD1     LCAPD2     LCAPD3     3MC1     3MC2     3MC3 N01312    SARS-CoV-2   N01489        C3 deficiency/ARMD9/AHUS5 N00589    HSV   N01493        CFB deficiency/ARMD14/AHUS4     N01494        CFP deficiency   N01490        C5D     C6D     C7D     C8D1     C8D2     C9D/ARMD15 N01505        CD59 deficiency   N01495    N01527    KSHV N01496        CFH deficiency/C3G1/BLD/ARMD4/AHUS1     CD55 deficiency     CFI deficiency/C3G2/ARMD13/AHUS3     AHUS2 N01528    KSHV N01504        ARMD1/AHUS1     ARMD1/AHUS1     C3G3   N01520        C1NH deficiency

C4a deficiency	H00102	Classic complement pathway component defects
C4b deficiency	H00102	Classic complement pathway component defects
C2 deficiency	H00102	Classic complement pathway component defects
ARMD14	H00821	Age-related macular degeneration
C1qa deficiency	H00102	Classic complement pathway component defects
C1qb deficiency	H00102	Classic complement pathway component defects
C1qc deficiency	H00102	Classic complement pathway component defects
C1r deficiency	H00102	Classic complement pathway component defects
EDSPD1	H02240	Ehlers-Danlos syndrome periodontal type
C1s deficiency	H00102	Classic complement pathway component defects
EDSPD2	H02240	Ehlers-Danlos syndrome periodontal type
SARS-CoV-2	H02398	COVID-19
KSHV	H00041	Kaposi sarcoma
LCAPD1	H00105	Mannose-binding lectin pathway component defects
LCAPD2	H00105	Mannose-binding lectin pathway component defects
LCAPD3	H00105	Mannose-binding lectin pathway component defects
3MC1	H01887	3MC syndrome
3MC2	H01887	3MC syndrome
3MC3	H01887	3MC syndrome
C3 deficiency	H00102	Classic complement pathway component defects
ARMD9	H00821	Age-related macular degeneration
AHUS5	H01434	Atypical hemolytic uremic syndrome
HSV	H00365	Herpes simplex virus infection
CFB deficiency	H00104	Alternative complement pathway component defects
AHUS4	H01434	Atypical hemolytic uremic syndrome
CFP deficiency	H00104	Alternative complement pathway component defects
C5D	H00103	Late complement pathway defects
C6D	H00103	Late complement pathway defects
C7D	H00103	Late complement pathway defects
C8D1	H00103	Late complement pathway defects
C8D2	H00103	Late complement pathway defects
C9D	H00103	Late complement pathway defects
ARMD15	H00821	Age-related macular degeneration
CD59 deficiency	H00106	Complement regulatory protein defects
CFH deficiency	H00104	Alternative complement pathway component defects
C3G1	H02579	C3 glomerulopathy
BLD	H02108	Basal laminar drusen
ARMD4	H00821	Age-related macular degeneration
AHUS1	H01434	Atypical hemolytic uremic syndrome
CD55 deficiency	H00106	Complement regulatory protein defects
CFI deficiency	H00106	Complement regulatory protein defects
C3G2	H02579	C3 glomerulopathy
ARMD13	H00821	Age-related macular degeneration
AHUS3	H01434	Atypical hemolytic uremic syndrome
AHUS2	H01434	Atypical hemolytic uremic syndrome
ARMD1	H00821	Age-related macular degeneration
C3G3	H02579	C3 glomerulopathy
C1NH deficiency	H00106	Complement regulatory protein defects