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ENTRY	nt06521
Name	NLR signaling
Category	Pathway view; Immune system
Pathway	hsa04621 NOD-like receptor signaling pathway
Display	drug-target relation   disease type

N00940            (NOD1,NOD2) → RIPK2 → IKK → NFKBIA → NFKB     IBD1         NOD2*     Blau syndrome         NOD2* ↗ N00941    Shigella             (IpaH9.8+TNIP1) ⊣ IKBKG N01112    Salmonella SopE/E2 → CDC42 → NOD1 → RIPK2 → IKK → NFKBIA → NFKB   N01567            (NLRP1+PYCARD) → CASP1 → (IL1B,IL18)     NAIAD/VAMAS1         NLRP1* ↗   N00742            (NLRP3+PYCARD) → CASP1 → (IL1B,IL18,IL33)     MWS/CINCA/FCAS1/DFNA34         NLRP3* ↗ N00743    IAV     NS1 ⊣ (NLRP3+PYCARD) N00864    Yersinia     YopK ⊣ (NLRP3+PYCARD) N00933    Escherichia     NleA ⊣ (NLRP3+PYCARD) N00948    Shigella IpaH7.8 ⊣ GLMN ⊣ (NLRP3+PYCARD) → CASP1 → IL1B N01127    Salmonella     SopE → RAC1 → CASP1 → (IL1B,IL18) N01126    Salmonella         SipB → CASP1 → (IL1B,IL18) N00863    Yersinia         YopM ⊣ CASP1 N01568        (CARD8,GPSM3,IRGM,.. ⊣ (NLRP3+PYCARD)     IBD30     CARD8*     IBD19     IRGM*   N01569            (NLRP12+PYCARD) → CASP1 → (IL1B,IL18)     FCAS2         NALP12* ↗   N00867            (NLRC4+PYCARD) → CASP1 → (IL1B,IL18)     FCAS4/AIFEC         NLRC4* ↗ N00865    Yersinia     YopK ⊣ (NLRC4+PYCARD) N00949    Shigella IpaB → K+ → (NLRC4+PYCARD) → CASP1 → IL1B   N00868            (MEFV+PYCARD) → CASP1 → (IL1B,IL18)     FMF/AFND         MEFV* ↗ N01570        PSTPIP1 → MEFV     PAPA     PSTPIP1* ↗ N00866    Yersinia YopM → (PKN1,PKN2) ⊣ (MEFV+PYCARD)   N00934    LPS → CASP4/5 → (NLRP3+PYCARD+CASP.. → (IL1B,IL18) N00935    Escherichia NleF ⊣ CASP4   N00515        OAS → 2-5A → RNASEL     IMD100     OAS1* ↗ N00273    HCV NS5A ⊣ OAS N00574    HSV US11 ⊣ OAS N00724    IAV NS1 ⊣ OAS

		Disease name	Disease category
IBD1	H01227	Inflammatory bowel disease (IBD)	Immune system disease
Blau syndrome	H00285	Blau syndrome	Immune system disease
Shigella	H00299	Shigellosis	Bacterial infectious disease
Salmonella	H00113	Salmonellosis	Bacterial infectious disease
NAIAD/VAMAS1	H02588	NLRP1-associated autoinflammation with arthritis and dyskeratosis	Immune system disease
	H01372	Vitiligo	Skin disease
MWS/CINCA/FCAS1/DFNA34	H02555	Muckle-Wells syndrome	Immune system disease
	H02556	CINCA syndrome	Immune system disease
	H02159	Familial cold autoinflammatory syndrome	Immune system disease
	H00604	Deafness, autosomal dominant	Nervous system disease
IAV	H00398	Influenza	Viral infectious disease
Yersinia	H00297	Plague	Bacterial infectious disease
	H00298	Yersiniosis	Bacterial infectious disease
Escherichia	H00277	Enterohemorrhagic Escherichia coli (EHEC) infection	Bacterial infectious disease
	H00278	Enteropathogenic Escherichia coli (EPEC) infection	Bacterial infectious disease
IBD30	H01227	Inflammatory bowel disease (IBD)	Immune system disease
IBD19	H01227	Inflammatory bowel disease (IBD)	Immune system disease
FCAS2	H02159	Familial cold autoinflammatory syndrome	Immune system disease
FCAS4/AIFEC	H02159	Familial cold autoinflammatory syndrome	Immune system disease
	H01748	NLRC4 inflammasomopathy	Immune system disease
FMF/AFND	H00288	Familial Mediterranean fever	Immune system disease
	H02590	Acute febrile neutrophilic dermatosis	Immune system disease
PAPA	H00287	Pyogenic sterile arthritis, pyoderma gangrenosum, and acne syndrome	Immune system disease
IMD100	H01725	Primary immunodeficiency disease	Immune system disease
HCV	H00048	Hepatocellular carcinoma	Cancer
HSV	H00365	Herpes simplex virus infection	Viral infectious disease