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ENTRY	nt06527
Name	Necroptosis
Category	Pathway view; Cellular process
Pathway	hsa04217 Necroptosis
Display	drug-target relation   disease type

N01621            TNF → TNFRSF1A → (TRAF2/5+TRADD+RIP..     TRAPS/MS5             TNFRSF1A* N01583                XIAP ⊣ (RIPK1+RIPK3+FADD+..     XLP2             XIAP* N01631            TNFSF10 → TNFRSF10 → (RIPK1+RIPK3)     HNSCC             TNFRSF10B* N01632        FASLG → FAS → FADD → (RIPK1+RIPK3)     ALPS1B     FASLG*     ALPS1A         FAS* N01625                CYLD → (RIPK1+RIPK3)     BRSS/FC/MFT/FTDALS8             CYLD* N01663                CASP8 ⊣ (RIPK1+RIPK3)     ALPS2B             CASP8* N01650                SQSTM1 → (RIPK1+RIPK3)     FTDALS3             SQSTM1* N01662    IFN → IFNR → JAKs → STAT+IRF9 ⇒ (RIPK1+RIPK3)     IMD44             STAT2*     IMD65             IRF9*     IMD57                 RIPK1*     AIEFL                 RIPK1* ↗   N01634        TLR4 → TICAM2 → TICAM1 → RIPK3     ARMD10     TLR4* ↗ N01633            TLR3 → TICAM1 → RIPK3     IIAE2         TLR3*     IIAE6             TICAM1*

		Disease name	Disease category
TRAPS/MS5	H00912	Tumor necrosis factor receptor-associated periodic syndrome	Immune system disease
	H01490	Multiple sclerosis	Immune system disease
XLP2	H01969	X-linked lymphoproliferative syndrome	Primary immunodeficiency
HNSCC	H02610	Head and neck squamous cell carcinoma	Cancer
ALPS1B	H00108	Autoimmune lymphoproliferative syndromes	Primary immunodeficiency
ALPS1A	H00108	Autoimmune lymphoproliferative syndromes	Primary immunodeficiency
BRSS/FC/MFT/FTDALS8	H00827	Brooke-Spiegler syndrome	Neoplasm
	H00828	Familial cylindromatosis	Neoplasm
	H00829	Multiple familial trichoepithelioma	Neoplasm
	H02342	Frontotemporal dementia and amyotrophic lateral sclerosis	Nervous system disease
ALPS2B	H00108	Autoimmune lymphoproliferative syndromes	Primary immunodeficiency
FTDALS3	H02342	Frontotemporal dementia and amyotrophic lateral sclerosis	Nervous system disease
IMD44	H02525	Disorders of innate immunity	Immune system disease
IMD65	H02525	Disorders of innate immunity	Immune system disease
IMD57	H02525	Disorders of innate immunity	Immune system disease
AIEFL	H02620	Autoinflammation with episodic fever and lymphadenopathy	Immune system disease
ARMD10	H00821	Age-related macular degeneration	Nervous system disease
IIAE2	H02536	Infection-induced acute encephalopathy	Nervous system disease
IIAE6	H02536	Infection-induced acute encephalopathy	Nervous system disease