KEGG    Network variation - Cytoskeleton in neurons
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ENTRYnt06541
NameCytoskeleton in neurons
CategoryPathway view; Cellular process
DiseaseH00266 Hereditary spastic paraplegia
H00058 Amyotrophic lateral sclerosis
H00268 Lissencephaly
H00264 Charcot-Marie-Tooth disease
H00768 Autosomal recessive intellectual developmental disorder
H00773 Autosomal dominant intellectual developmental disorder
H01881 Complex cortical dysplasia with other brain malformations
H02022 Griscelli syndrome
Display drug-target relation   disease type
N01857    SEMA3ANES=(CDK5+CDK5R1)DCX=(TUBA+TUBB)
N01835    SEMA3APLXNA1+NRP1FYN,FES,FER(CDK5+CDK5R1)CRMP1/2,MAPT=(TUBA+TUBB)
N01834    SEMA3AFMRPMAP1B=(TUBA+TUBB)
N01832    NTN1GSK3B,CDK5MAP1B=(TUBA+TUBB)
N01858    EFNB1EPHB2PI3KPIP3AKTGSK3BMAPT=(TUBA+TUBB)
N01833    DRAXINDCCAKTGSK3BMAP1B=(TUBA+TUBB)
    HH16 SEMA3A*
    MRMV4 NTN1*
    CFNS EFNB1*
    DWOPNED   PLXNA1*
    FXS/POF1/FXTAS   FMR1*
    MRMV1/HGPPS2   DCC*
    PVNH9/DFNA83     MAP1B*
    LISX1       DCX*
    ALSPDC/PSNP1             MAPT*
 
N01836    (TUBA+TUBB)=MAPRE1,MAPRE3=SxlPs,TOGs,CAP-Gly..
    FAP1     APC*
    MRT74/CDCBM10     APC2*
    LIS9     MACF1*
    HSAN6/EBS3     DST*
N01837    (TUBA+TUBB)=MAPRE1(NAV1+TRIO)RAC1Actin
    MRD44     TRIO*
    MRD63     TRIO*
N01838    (TUBA+TUBB)=MAPRE3=SRCIN1+SRC+CIT+CTT..CFLActin
    MCPH17     CIT*
 
N01846    ActivatorDynein=Dynactin=(TUBA+TUBB)
    SMALED2 BICD2*
    NEDBA MAPK8IP3*
    CMT2O/SMALED1/CDCBM13   DYNC1H1*
    SRTD3   DYNC2H1*
    NEDMIBA   DYNC1I2*
    ALS1/HMND14/PS     DCTN1*
N01847    (CDK5+CDK5R1)NDEL1,(NDE1+NDEL1+..=Dynein=TUBA1
    LIS4/MHAC   NDE1*
    LIS1/MDS   LIS1*
N01840        KIF2A(TUBA+TUBB)
    CDCBM3     KIF2A*
N01859      (TRAK1/2)=(KIF5+KLC)=(TUBA+TUBB)
    DEE68   TRAK1*
    SPG10/NEIMY     KIF5A*
    ALS25     KIF5A*
    CDCBM2     KIF5C*
    SPOAN     KLC2*
N01841        (KIF3+KIFAP3)=(TUBA+TUBB)
    RP89     KIF3B*
N01842        KIF1=(TUBA+TUBB)
    HSAN2C/SPG30/MRD9     KIF1A*
    CMT2A1     KIF1B*
    SPAX2     KIF1C*
N01843        KIF21=(TUBA+TUBB)
    CFEOM1/3B     KIF21A*
N01844        KIF23=(TUBA+TUBB)
    CDAIIIA     KIF23*
N01845        KIF15=(TUBA+TUBB)
    BRDCS2     KIF15*
N01839        SPAST,(KATNA1+KATN..(TUBA+TUBB)
    SPG4     SPAST*
    SPG4     SPAST*
    LIS6     KATNB1*
    LIS3       TUBA1A*
    KTCN       TUBA3D*
    ALS22       TUBA4A*
    MACTHC2       TUBA8*
    CDCBM6/CSCSC1       TUBB*
    MACTHC1       TUBB1*
    CDCBM5       TUBB2A*
    CDCBM7       TUBB2B*
    CDCBM1/CFEOM3A       TUBB3*
    HLD6/DYT4       TUBB4A*
    LCAEOD       TUBB4B*
    FPVEPD       TUBB6*
    OOMD2       TUBB8*
 
N01161    Actin(monomeric)=PFN1Actin(filamentous)
    BNS ACTB*
    BRWS1/DDS1 ACTB*
    DFNA20/26/BRWS2 ACTG1*
    ALS18   PFN1*
N01848    Actin_ring=ADD1/2/3+TMOD1/2/3=SPTAN1+SPTBN1/4/5=ANK3=(NFASC,SCN8A,KCNQ2..
    EHT   ADD1*
    CPSQ3   ADD3*
    SPG91/DEE5/HMND11     SPTAN1*
    DDISBA     SPTBN1*
    CMND     SPTBN4*
N01849    Actin_ring=(MYH9+MYL6+MYL12)
    MATINS/DFNA17   MYH9*
N01850    Actin=MYO5B+CAMK2A/B+DYN..=RAB11FIP2=RAB11A/B=GRIA1
    PFIC10/DIAR2/MVID1   MYO5B*
    MRT63   CAMK2A*
    MRD53   CAMK2A*
    MRD54   CAMK2B*
    NDAGSCW     RAB11B*
    MRD67         GRIA1*
    MRT76         GRIA1*
N01851    Actin=MYO5A+MLPH+RAB27A=Melanosome
    GS1   MYO5A*
    GS3   MLPH*
    GS2   RAB27A*
N01852    Actin=MYO6=Adaptor=Vesicle
    DFNA22/DFNB37   MYO6*
    OPDM2     GIPC1*
 
N01853    NEFL,(PRPH,PRPH2,I..=NEFM,NEFH
    CMT1F/2E/DIG NEFL*
    ALS1 PRPH*
    RP7/VMD3/CACD2/MDPT1 PRPH2*
    ALS1   NEFH*
    CMT2CC   NEFH*
N01854    TRIM2+UBE2D1NEFL
    CMT2R TRIM2*
N01855    (RBX1+CUL3+KLHL16)..(NEFL,NEFM,NEFH,VI..
    NEDAUS CUL3*
    GAN1 GAN*
 
N01856    PCLO+BSN=ERC2=RIMS1=UNC13A,UNC13B,UNC1..=RAB3A,STX1A
    PCH3 PCLO*

Disease nameDisease category
HH16H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
MRMV4H01287Congenital mirror movementsNervous system disease
CFNSH00458Syndromic craniosynostosesCongenital malformation
DWOPNEDH02688Dworschak-Punetha neurodevelopmental syndromeCongenital malformation
FXS/POF1/FXTASH00465Fragile X syndromeChromosomal abnormality
H00627Premature ovarian failureReproductive system disease
H01731Fragile X tremor/ataxia syndromeChromosomal abnormality
MRMV1/HGPPS2H01287Congenital mirror movementsNervous system disease
H02450Horizontal gaze palsy with progressive scoliosisNervous system disease
PVNH9/DFNA83H00270Periventricular nodular heterotopiaCongenital malformation
H00604Deafness, autosomal dominantNervous system disease
LISX1H00268LissencephalyCongenital malformation
ALSPDC/PSNP1H00058Amyotrophic lateral sclerosis (ALS)Neurodegenerative disease
H00077Progressive supranuclear palsyNeurodegenerative disease
FAP1H01025Familial adenomatous polyposisNeoplasm
MRT74/CDCBM10H00768Autosomal recessive intellectual developmental disorderMental and behavioural disorder
H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
LIS9H00268LissencephalyCongenital malformation
HSAN6/EBS3H00265Hereditary sensory and autonomic neuropathyNervous system disease
H00584Epidermolysis bullosa simplexCongenital malformation
MRD44H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
MRD63H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
MCPH17H00269Primary microcephalyCongenital malformation
SMALED2H00455Spinal muscular atrophyNeurodegenerative disease
NEDBAH02470Neurodevelopmental disorder with structural brain abnormalitiesCongenital malformation
CMT2O/SMALED1/CDCBM13H00264Charcot-Marie-Tooth diseaseNeurodegenerative disease
H00455Spinal muscular atrophyNeurodegenerative disease
H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
SRTD3H02157Short-rib thoracic dysplasiaCongenital malformation
NEDMIBAH02461Neurodevelopmental disorder with microcephalyCongenital malformation
ALS1/HMND14/PSH00058Amyotrophic lateral sclerosis (ALS)Neurodegenerative disease
H00856Distal hereditary motor neuropathiesNervous system disease
H00879Perry syndromeNeurodegenerative disease
LIS4/MHACH00268LissencephalyCongenital malformation
H01870MicrohydranencephalyCongenital malformation
LIS1/MDSH00268LissencephalyCongenital malformation
CDCBM3H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
DEE68H00606Early infantile epileptic encephalopathyNervous system disease
SPG10/NEIMYH00266Hereditary spastic paraplegiaNervous system disease
H02819Neonatal intractable myoclonusNervous system disease
ALS25H00058Amyotrophic lateral sclerosis (ALS)Neurodegenerative disease
CDCBM2H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
SPOANH02114Spastic paraplegia, optic atrophy, and neuropathyNervous system disease
RP89H00527Retinitis pigmentosaNervous system disease
HSAN2C/SPG30/MRD9H00265Hereditary sensory and autonomic neuropathyNervous system disease
H00266Hereditary spastic paraplegiaNervous system disease
H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
CMT2A1H00264Charcot-Marie-Tooth diseaseNeurodegenerative disease
SPAX2H01351Spastic ataxiaNeurodegenerative disease
CFEOM1/3BH00838Congenital fibrosis of the extraocular musclesNervous system disease
CDAIIIAH00917Congenital dyserythropoietic anemiaHematologic disease
BRDCS2H02663Braddock-Carey syndromeCongenital malformation
SPG4H00266Hereditary spastic paraplegiaNervous system disease
LIS6H00268LissencephalyCongenital malformation
LIS3H00268LissencephalyCongenital malformation
KTCNH00789KeratoconusNervous system disease
ALS22H00058Amyotrophic lateral sclerosis (ALS)Neurodegenerative disease
MACTHC2H01740MacrothrombocytopeniaHematologic disease
CDCBM6/CSCSC1H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
H01579Congenital symmetric circumferential skin creasesCongenital malformation
MACTHC1H01740MacrothrombocytopeniaHematologic disease
CDCBM5H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
CDCBM7H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
CDCBM1/CFEOM3AH01881Complex cortical dysplasia with other brain malformationsCongenital malformation
H00838Congenital fibrosis of the extraocular musclesNervous system disease
HLD6/DYT4H00679Hypomyelinating leukodystrophyInherited metabolic disorder
H00831Primary dystoniaNervous system disease
LCAEODH00837Leber congenital amaurosisNervous system disease
FPVEPDH02594Congenital facial palsy with ptosis and velopharyngeal dysfunctionNervous system disease
OOMD2H01897Oocyte/zygote/embryo maturation arrestReproductive system disease
BNSH02716Becker nevus syndromeCongenital malformation
BRWS1/DDS1H02023Baraitser-Winter syndromeCongenital malformation
H01255Juvenile-onset dystoniaCongenital malformation
DFNA20/26/BRWS2H00604Deafness, autosomal dominantNervous system disease
H02023Baraitser-Winter syndromeCongenital malformation
ALS18H00058Amyotrophic lateral sclerosis (ALS)Neurodegenerative disease
EHTH01633High blood pressureCardiovascular disease
CPSQ3H01097Spastic quadriplegic cerebral palsyNervous system disease
SPG91/DEE5/HMND11H00266Hereditary spastic paraplegiaNervous system disease
H00606Early infantile epileptic encephalopathyNervous system disease
H00856Distal hereditary motor neuropathiesNervous system disease
DDISBAH02685Developmental delay with neuropsychiatric disordersCongenital malformation
CMNDH01810Congenital myopathyNervous system disease
MATINS/DFNA17H00233MYH9-related diseaseCardiovascular disease
H00604Deafness, autosomal dominantNervous system disease
PFIC10/DIAR2/MVID1H00624Progressive familial intrahepatic cholestasisInherited metabolic disorder
H01174Congenital diarrheaDigestive system disease
MRT63H00768Autosomal recessive intellectual developmental disorderMental and behavioural disorder
MRD53H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
MRD54H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
NDAGSCWH02470Neurodevelopmental disorder with structural brain abnormalitiesCongenital malformation
MRD67H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
MRT76H00768Autosomal recessive intellectual developmental disorderMental and behavioural disorder
GS1H02022Griscelli syndromePrimary immunodeficiency
GS3H02022Griscelli syndromePrimary immunodeficiency
GS2H02022Griscelli syndromePrimary immunodeficiency
DFNA22/DFNB37H00604Deafness, autosomal dominantNervous system disease
H00605Deafness, autosomal recessiveNervous system disease
OPDM2H02513Oculopharyngodistal myopathyMusculoskeletal disease
CMT1F/2E/DIGH00264Charcot-Marie-Tooth diseaseNeurodegenerative disease
ALS1H00058Amyotrophic lateral sclerosis (ALS)Neurodegenerative disease
RP7/VMD3/CACD2/MDPT1H00527Retinitis pigmentosaNervous system disease
H00814Vitelliform macular dystrophyNervous system disease
H01768Central areolar choroidal dystrophyNervous system disease
H01890Pattern dystrophies of the retinal pigment epitheliumNervous system disease
CMT2CCH00264Charcot-Marie-Tooth diseaseNeurodegenerative disease
CMT2RH00264Charcot-Marie-Tooth diseaseNeurodegenerative disease
NEDAUSH02715Neurodevelopmental disorder with defects of ubiquitin-proteasome systemCongenital malformation
GAN1H01259Giant axonal neuropathyNeurodegenerative disease
PCH3H00897Pontocerebellar hypoplasiaCongenital malformation