| Entry |
|
|---|
| Name |
Lofexidine hydrochloride (USAN);
Lofexidine (TN);
Lucemyra (TN) |
|---|
| Product |
|
|---|
| Formula |
C11H12Cl2N2O. HCl
|
|---|
| Exact mass |
294.0093
|
|---|
| Mol weight |
295.5927
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
|
|---|
| Remark |
| Product (DG01001): | D04765<US> |
|
|---|
| Efficacy |
Antihypertensive, alpha2-Adrenergic receptor agonist |
|---|
| Comment |
Mitigation of opioid withdrawal symptoms to facilitate abrupt opioid discontinuation
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07B DRUGS USED IN ADDICTIVE DISORDERS
N07BC Drugs used in opioid dependence
N07BC04 Lofexidine
D04765 Lofexidine hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
Anti-Addiction/Substance Abuse Treatment Agents
Opioid Dependence
Lofexidine
D04765 Lofexidine hydrochloride (USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG01001 Lofexidine
D04765 Lofexidine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D04765 Lofexidine hydrochloride (USAN) <US>
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D04765
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG01001 Lofexidine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 17
1 C8x C 27.1048 -17.3043
2 C8x C 27.1048 -18.7100
3 C8x C 28.3222 -19.4128
4 C8y C 29.5396 -18.7100
5 C8y C 29.5396 -17.3043
6 C8y C 28.3222 -16.6014
7 X Cl 28.3222 -15.1959
8 X Cl 30.7757 -19.4239
9 O2a O 30.7757 -16.5904
10 C1c C 31.9858 -17.2889
11 C2y C 33.1729 -16.6033
12 C1a C 31.9862 -18.7096
13 N1x N 34.4884 -17.0360
14 C1x C 35.3055 -15.9197
15 C1x C 34.4963 -14.7978
16 N2x N 33.1792 -15.2206
17 X Cl 37.0150 -17.9368
BOND 17
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 4 8 1
9 5 9 1
10 9 10 1
11 10 11 1
12 10 12 1
13 11 13 1
14 13 14 1
15 14 15 1
16 15 16 1
17 11 16 2
|
|---|
