KEGG   DRUG: Ledipasvir and sofosbuvir
Entry
D10578            Mixture   Drug                                   
Name
Ledipasvir and sofosbuvir;
Harvoni (TN)
Product
  Generic
Component
Ledipasvir [DR:D10442], Sofosbuvir [DR:D10366]
Class
Antiviral
 DG03198  Anti-HCV agent
Transporter substrate
 DG01665  ABCB1 substrate
 DG01913  ABCG2 substrate
Remark
Therapeutic category: 6250
ATC code: J05AP51
Product: D10578<JP/US>
Efficacy
Antiviral
  Disease
Chronic hepatitis C virus infection [DS:H00413]
Target
HCV NS5A [KO:K22275]
HCV NS5B [KO:K22472]
  Pathway
ko03230  Viral genome structure
ko03240  Viral replication
ko05160  Hepatitis C
Metabolism
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AP Antivirals for treatment of HCV infections
     J05AP51 Sofosbuvir and ledipasvir
      D10578  Ledipasvir and sofosbuvir <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis C (HCV) Agents
   Ledipasvir/ Sofosbuvir
    D10578  Ledipasvir and sofosbuvir
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D10578  Ledipasvir and sofosbuvir
Drug groups [BR:br08330]
 Antiviral
  DG03198  Anti-HCV agent
   D10578  Ledipasvir and sofosbuvir
 Transporter substrate
  DG01665  ABCB1 substrate
   D10578  Ledipasvir and sofosbuvir
  DG01913  ABCG2 substrate
   D10578  Ledipasvir and sofosbuvir
Drug classes [BR:br08332]
 Antiviral
  DG03198  Anti-HCV agent
   D10578  Ledipasvir and sofosbuvir
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HCV NS5A/NS5B inhibitor
    D10578  Ledipasvir and sofosbuvir <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10578
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10578
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10578
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10578
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D10578
Other DBs
PubChem: 254741540
ChEBI: 85082
LinkDB

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