NETWORK: N00076
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Entry
N00076 Network
Name
Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
Definition
CDKN2A* // MDM2 -| TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F
Expanded
1029v2 // 4193 -| 7157 => 1026 -| ((595,
894,
896)+(1019,
1021)) -> 5925 // (1869,
1870,
1871)
Class
nt06268
Melanoma
nt06230
Cell cycle (cancer)
Type
Variant
Pathway
hsa05218
Melanoma
Disease
H00038
Melanoma
Gene
1029
CDKN2A; cyclin dependent kinase inhibitor 2A
4193
MDM2; MDM2 proto-oncogene
7157
TP53; tumor protein p53
1026
CDKN1A; cyclin dependent kinase inhibitor 1A
595
CCND1; cyclin D1
894
CCND2; cyclin D2
896
CCND3; cyclin D3
1019
CDK4; cyclin dependent kinase 4
1021
CDK6; cyclin dependent kinase 6
5925
RB1; RB transcriptional corepressor 1
1869
E2F1; E2F transcription factor 1
1870
E2F2; E2F transcription factor 2
1871
E2F3; E2F transcription factor 3
Variant
1029v2
(CDKN2A*) CDKN2A mutation
Reference
PMID:
16822996
Authors
Miller AJ, Mihm MC Jr.
Title
Melanoma.
Journal
N Engl J Med 355:51-65 (2006)
DOI:
10.1056/NEJMra052166
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