KEGG   NETWORK: N00152
Entry
N00152                      Network                                
Name
CXCR-GNB/G-ERK signaling pathway
Definition
CXCL8 -> CXCR2 -> GNB/G -> RAS -> RAF1 -> MEK -> ERK
  Expanded
3576 -> 3579 -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793) -> (3265,3845,4893) -> 5894 -> (5604,5605) -> (5594,5595)
Class
nt06224 CXCR signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04062  Chemokine signaling pathway
Gene
3576  CXCL8; C-X-C motif chemokine ligand 8
3579  CXCR2; C-X-C motif chemokine receptor 2
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
PMID:18980965
  Authors
Waugh DJ, Wilson C
  Title
The interleukin-8 pathway in cancer.
  Journal
Clin Cancer Res 14:6735-41 (2008)
DOI:10.1158/1078-0432.CCR-07-4843
Reference
PMID:24276377
  Authors
Campbell LM, Maxwell PJ, Waugh DJ
  Title
Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer.
  Journal
Pharmaceuticals (Basel) 6:929-59 (2013)
DOI:10.3390/ph6080929
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