KEGG   DRUG: D00063Help
Entry
D00063                      Drug                                   

Name
Tobramycin (JP16/USP);
TOB;
Tobi (TN);
Tobracin (TN);
Tobrex (TN)
Product
  Generic
Formula
C18H37N5O9
Exact mass
467.2591
Mol weight
467.5145
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Streptomyces tenebrarius [TAX:1933]
Activity
Antibacterial
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Natural product
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB01 Tobramycin
      D00063  Tobramycin (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA12 Tobramycin
      D00063  Tobramycin (JP16/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Tobramycin
    D00063  Tobramycin (JP16/USP)
 Respiratory Tract/Pulmonary Agents
  Cystic Fibrosis Agents
   Tobramycin dry-powder inhaler
    D00063  Tobramycin (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1317  Ophthalmic antibiotics
     D00063  Tobramycin (JP16/USP)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   612  Acting mainly on gram-negative bacteria
    6123  Amino sugars
     D00063  Tobramycin (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Aminoglycosides
     Tobramycin
      D00063  Tobramycin (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00063  Tobramycin
  D00063 Tobramycin injection
BRITE hierarchy
Other DBs
CAS: 
32986-56-4
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        32
            1   C1y C    20.6560  -20.0968
            2   C1y C    20.6560  -21.4973
            3   C1y C    21.8689  -22.1975
            4   C1y C    23.0818  -21.4973
            5   C1y C    23.0818  -20.0968
            6   O2x O    21.8689  -19.3965
            7   C1b C    19.4432  -19.3965
            8   O1a O    18.2473  -20.0872
            9   O1a O    19.4432  -22.1975
            10  N1a N    21.8689  -23.5978
            11  O1a O    24.3134  -22.2085
            12  O2a O    24.3134  -19.3855
            13  C1y C    25.4878  -18.6963
            14  C1y C    26.7056  -19.3879
            15  C1x C    27.9134  -18.6791
            16  C1y C    27.9035  -17.2786
            17  C1y C    26.6857  -16.5869
            18  C1y C    25.4779  -17.2958
            19  N1a N    26.7157  -20.7965
            20  N1a N    29.0779  -16.5893
            21  O1a O    24.2675  -16.6084
            22  O2a O    26.6757  -15.1950
            23  C1y C    27.8854  -14.4851
            24  O2x O    29.0946  -15.1718
            25  C1y C    30.3025  -14.4631
            26  C1y C    30.2926  -13.0626
            27  C1x C    29.0835  -12.3758
            28  C1y C    27.8755  -13.0846
            29  C1b C    31.5468  -15.1693
            30  N1a N    31.5569  -16.5953
            31  O1a O    31.5060  -12.3503
            32  N1a N    26.6567  -12.3923
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1 #Up
            8     7   8 1
            9     2   9 1 #Down
            10    3  10 1 #Up
            11    4  11 1 #Down
            12    5  12 1 #Down
            13   13  12 1 #Down
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   14  19 1 #Up
            21   16  20 1 #Up
            22   18  21 1 #Up
            23   17  22 1 #Down
            24   23  22 1 #Down
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   23  28 1
            31   25  29 1 #Up
            32   29  30 1
            33   26  31 1 #Down
            34   28  32 1 #Down

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