KEGG   DRUG: D00076Help
Entry
D00076                      Drug                                   
Name
Noradrenaline (JP16);
Norepinephrine (INN);
Nor adrenalin (TN)
Formula
C8H11NO3
Exact mass
169.0739
Mol weight
169.1778
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Adrenergic [vasoconstrictor]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor agonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
beta1-adrenergic receptor agonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor agonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: MAOA [HSA:4128]
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2451  Epinephrines
     D00076  Noradrenaline (JP16); Norepinephrine (INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA03 Norepinephrine
      D00076  Noradrenaline (JP16); Norepinephrine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Norepinephrine [ATC:C01CA03]
      D00076  Norepinephrine (INN)
    alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
     Norepinephrine [ATC:C01CA03]
      D00076  Norepinephrine (INN)
    beta1-adrenergic receptor [HSA:153] [KO:K04141]
     Norepinephrine [ATC:C01CA03]
      D00076  Norepinephrine (INN)
    beta2-adrenergic receptor [HSA:154] [KO:K04142]
     Norepinephrine [ATC:C01CA03]
      D00076  Norepinephrine (INN)
    beta3-adrenergic receptor [HSA:155] [KO:K04143]
     Norepinephrine [ATC:C01CA03]
      D00076  Norepinephrine (INN)
BRITE hierarchy
Other DBs
CAS: 
51-41-2
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        12
            1   C8y C    25.1107  -17.0137
            2   C8x C    25.1107  -18.4285
            3   C8x C    23.8950  -16.3188
            4   C1c C    26.3149  -16.3188
            5   C8x C    23.8950  -19.1423
            6   C8y C    22.6850  -17.0137
            7   C1b C    27.5246  -17.0080
            8   O1a O    26.3149  -14.9217
            9   C8y C    22.6850  -18.4285
            10  N1a N    28.7227  -16.3130
            11  O1a O    21.4681  -19.1189
            12  O1a O    21.4728  -16.3208
BOND        12
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 1 #Up
            8     5   9 2
            9     7  10 1
            10    9  11 1
            11    6   9 1
            12    6  12 1

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