KEGG   DRUG: DisulfiramHelp
Entry
D00131                      Drug                                   

Name
Disulfiram (JP17/USP/INN);
Antabuse (TN)
Product
  Generic
Formula
C10H20N2S4
Exact mass
296.0509
Mol weight
296.5392
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01718  Drugs for addictive disorder
  DG01716  Drugs for alcohol dependence
Cyp inhibitor
 DG01634  CYP1A2 inhibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Alcohol antagonist
Target
aldehyde dehydrogenase inhibitor [HSA:217 219 224] [KO:K00128]
  Pathway
Glycolysis / Gluconeogenesis
Ascorbate and aldarate metabolism
Fatty acid degradation
Valine, leucine and isoleucine degradation
Lysine degradation
Arginine and proline metabolism
Histidine metabolism
Tryptophan metabolism
beta-Alanine metabolism
Glycerolipid metabolism
Pyruvate metabolism
Interaction
CYP inhibition: CYP2E1 [HSA:1571], CYP1A2 [HSA:1544]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BB Drugs used in alcohol dependence
     N07BB01 Disulfiram
      D00131  Disulfiram (JP17/USP/INN)
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P03 ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS
   P03A ECTOPARASITICIDES, INCL. SCABICIDES
    P03AA Sulfur containing products
     P03AA04 Disulfiram
      D00131  Disulfiram (JP17/USP/INN)
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Alcohol Deterrents/Anti-craving
   Disulfiram
    D00131  Disulfiram (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   393  Habitual intoxication agents
    3939  Others
     D00131  Disulfiram (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   aldehyde dehydrogenase
    Disulfiram
     D00131  Disulfiram (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP1A2
   Disulfiram
    D00131  Disulfiram (JP17/USP/INN)
  CYP2C9
   Disulfiram
    D00131  Disulfiram (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00131  Disulfiram
BRITE hierarchy
Other DBs
CAS: 
97-77-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        16
            1   N1c N    18.9962  -16.1700
            2   C2c C    20.2135  -16.8721
            3   C1b C    17.7852  -16.8721
            4   C1b C    18.9962  -14.7723
            5   S3a S    21.4244  -16.1700
            6   S0  S    20.2135  -18.2762
            7   C1a C    16.5743  -16.1700
            8   C1a C    17.7852  -14.0703
            9   S3a S    22.8221  -16.1636
            10  C2c C    24.0265  -16.8656
            11  N1c N    25.2438  -16.1700
            12  S0  S    24.0200  -18.2633
            13  C1b C    26.4548  -16.8721
            14  C1b C    25.2438  -14.7659
            15  C1a C    27.6657  -16.1764
            16  C1a C    26.4611  -14.0703
BOND        15
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     9  10 1
            10   10  11 1
            11   10  12 2
            12   11  13 1
            13   11  14 1
            14   13  15 1
            15   14  16 1

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