KEGG   DRUG: VoriconazoleHelp
Entry
D00578                      Drug                                   

Name
Voriconazole (JP17/USAN/INN);
Vfend (TN)
Product
  Generic
VORICONAZOLE (APPCO PHARMA LLC), VORICONAZOLE (Ajanta Pharma Limited), VORICONAZOLE (Alvogen), VORICONAZOLE (American Health Packaging), VORICONAZOLE (Amneal Pharmaceuticals of New York), VORICONAZOLE (Aurobindo Pharma Limited), VORICONAZOLE (AvKARE), VORICONAZOLE (Cadila Healthcare Limited), VORICONAZOLE (Cardinal Health), VORICONAZOLE (Glenmark Pharmaceuticals), VORICONAZOLE (Lupin Pharmaceuticals), VORICONAZOLE (Lupin Pharmaceuticals), VORICONAZOLE (Major Pharmaceuticals), VORICONAZOLE (McKesson Packaging Services a business unit of McKesson Corporation), VORICONAZOLE (Mylan Institutional), VORICONAZOLE (Mylan Pharmaceuticals), VORICONAZOLE (Mylan Pharmaceuticals), VORICONAZOLE (Northstar Rx LLC), VORICONAZOLE (Novel Laboratories), VORICONAZOLE (Novel Laboratories), VORICONAZOLE (Sandoz), VORICONAZOLE (Sandoz), VORICONAZOLE (Teva Pharmaceuticals USA), VORICONAZOLE (VersaPharm Incorporated), VORICONAZOLE (Zydus Pharmaceuticals (USA))
Formula
C16H14F3N5O
Exact mass
349.115
Mol weight
349.3105
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antifungal
 DG01523  Triazole antifungal
Cyp substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01643  CYP2C9 inhibitor
 DG01933  CYP2C19 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Antifungal, Ergosterol biosynthesis inhibitor
Comment
Triazole derivative
Target
sterol 14alpha-demethylase [KO:K05917]
  Pathway
Steroid biosynthesis
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP3A [HSA:1576 1577 1551], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
Drug interaction
Structure map
Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AC Triazole derivatives
     J02AC03 Voriconazole
      D00578  Voriconazole (JP17/USAN/INN)
USP drug classification [BR:br08302]
 Antifungals
  Voriconazole
   D00578  Voriconazole (JP17/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   617  Acting mainly on mold
    6179  Others
     D00578  Voriconazole (JP17/USAN/INN)
Antiinfectives [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   sterol 14alpha-demethylase inhibitor
    Triazoles
     Voriconazole
      D00578  Voriconazole (JP17/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2B6
   Voriconazole
    D00578  Voriconazole (JP17/USAN/INN)
  CYP2C9
   Voriconazole
    D00578  Voriconazole (JP17/USAN/INN)
  CYP2C19
   Voriconazole
    D00578  Voriconazole (JP17/USAN/INN)
  CYP3A
   Voriconazole
    D00578  Voriconazole (JP17/USAN/INN)
 CYP substrates
  CYP2C9
   Voriconazole
    D00578  Voriconazole (JP17/USAN/INN)
  CYP2C19
   Voriconazole
    D00578  Voriconazole (JP17/USAN/INN)
  CYP3A4
   Voriconazole
    D00578  Voriconazole (JP17/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00578  Voriconazole
  D00578  Voriconazole tablets
Antifungals [br08352.html]
 D00578
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D00578
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00578
BRITE hierarchy
Other DBs
CAS: 
137234-62-9
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        25
            1   C1d C    25.0014  -20.8416
            2   C8y C    25.0014  -18.5274
            3   C1c C    23.8241  -21.5118
            4   C1b C    26.1673  -21.5178
            5   O1a O    25.0014  -22.1939
            6   C8y C    26.1614  -17.8513
            7   C8x C    23.8241  -17.8513
            8   C8y C    22.6232  -20.8240
            9   C1a C    23.8181  -22.8992
            10  N4y N    27.3447  -20.8357
            11  C8x C    26.1614  -16.5049
            12  X   F    27.3389  -18.5274
            13  C8x C    23.8241  -16.5049
            14  C8y C    21.4225  -21.5118
            15  N5x N    22.6349  -19.4367
            16  C8x C    27.4030  -19.4950
            17  N5x N    28.5688  -21.3895
            18  C8y C    25.0014  -15.8228
            19  C8x C    20.2216  -20.8183
            20  X   F    21.4225  -22.8992
            21  C8x C    21.4283  -18.7374
            22  N5x N    28.7960  -19.2095
            23  C8x C    29.4839  -20.3869
            24  X   F    25.0014  -14.4647
            25  N5x N    20.2216  -19.4310
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    6  11 1
            11    6  12 1
            12    7  13 2
            13    8  14 1
            14    8  15 2
            15   10  16 1
            16   10  17 1
            17   11  18 2
            18   14  19 2
            19   14  20 1
            20   15  21 1
            21   16  22 2
            22   17  23 2
            23   18  24 1
            24   19  25 1
            25   13  18 1
            26   21  25 2
            27   22  23 1

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