KEGG   DRUG: D00578Help
Entry
D00578                      Drug                                   

Name
Voriconazole (JAN/USAN/INN);
Vfend (TN)
Product
  Generic
Formula
C16H14F3N5O
Exact mass
349.115
Mol weight
349.3105
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antifungal [DS:H00363]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
sterol 14alpha-demethylase ihibitor [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP3A [HSA:1576 1577 1551], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
Drug interaction
Structure map
Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AC Triazole derivatives
     J02AC03 Voriconazole
      D00578  Voriconazole (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antifungals
  Voriconazole
   D00578  Voriconazole (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   617  Acting mainly on mold
    6179  Others
     D00578  Voriconazole (JAN/USAN/INN)
Antiinfectives [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   sterol 14alpha-demethylase inhibitor
    Triazoles
     Voriconazole
      D00578  Voriconazole (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Voriconazole
    D00578  Voriconazole (JAN/USAN/INN)
  CYP2C19
   Voriconazole
    D00578  Voriconazole (JAN/USAN/INN)
  CYP3A4
   Voriconazole
    D00578  Voriconazole (JAN/USAN/INN)
 Inhbitors
  CYP2C9
   Voriconazole
    D00578  Voriconazole (JAN/USAN/INN)
  CYP2C19
   Voriconazole
    D00578  Voriconazole (JAN/USAN/INN)
  CYP3A
   Voriconazole
    D00578  Voriconazole (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
137234-62-9
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        25
            1   C1d C    25.0014  -20.8416
            2   C8y C    25.0014  -18.5274
            3   C1c C    23.8241  -21.5118
            4   C1b C    26.1673  -21.5178
            5   O1a O    25.0014  -22.1939
            6   C8y C    26.1614  -17.8513
            7   C8x C    23.8241  -17.8513
            8   C8y C    22.6232  -20.8240
            9   C1a C    23.8181  -22.8992
            10  N4y N    27.3447  -20.8357
            11  C8x C    26.1614  -16.5049
            12  X   F    27.3389  -18.5274
            13  C8x C    23.8241  -16.5049
            14  C8y C    21.4225  -21.5118
            15  N5x N    22.6349  -19.4367
            16  C8x C    27.4030  -19.4950
            17  N5x N    28.5688  -21.3895
            18  C8y C    25.0014  -15.8228
            19  C8x C    20.2216  -20.8183
            20  X   F    21.4225  -22.8992
            21  C8x C    21.4283  -18.7374
            22  N5x N    28.7960  -19.2095
            23  C8x C    29.4839  -20.3869
            24  X   F    25.0014  -14.4647
            25  N5x N    20.2216  -19.4310
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    6  11 1
            11    6  12 1
            12    7  13 2
            13    8  14 1
            14    8  15 2
            15   10  16 1
            16   10  17 1
            17   11  18 2
            18   14  19 2
            19   14  20 1
            20   15  21 1
            21   16  22 2
            22   17  23 2
            23   18  24 1
            24   19  25 1
            25   13  18 1
            26   21  25 2
            27   22  23 1

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