KEGG   DRUG: BuforminHelp
Entry
D00595                      Drug                                   

Name
Buformin (USAN/INN)
Formula
C6H15N5
Exact mass
157.1327
Mol weight
157.2168
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
Unclassified
 DG02044  Hypoglycemics
  DG01684  Biguanide antidiabetic
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antidiabetic, Hypoglycemic
Comment
biguanides
Target
AMPK (PRKAA) [HSA:5562 5563] [KO:K07198]
  Pathway
Autophagy - animal
mTOR signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Interaction
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA03 Buformin
      D00595  Buformin (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: CAMK group
   CAMKL family
    AMPK
     Buformin
      D00595  Buformin (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
692-13-7
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        11
            1   N1b N    21.2128  -16.3163
            2   C2c C    19.9976  -17.0197
            3   C1b C    22.4221  -17.0197
            4   N1b N    18.7881  -16.3163
            5   N2a N    19.9976  -18.4210
            6   C1b C    23.6372  -16.3163
            7   C2c C    17.5788  -17.0197
            8   C1b C    24.8465  -17.0197
            9   N1a N    16.3695  -16.3163
            10  N2a N    17.5788  -18.4210
            11  C1a C    26.0501  -16.3163
BOND        10
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     6   8 1
            8     7   9 1
            9     7  10 2
            10    8  11 1

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