KEGG   DRUG: Oxymetazoline hydrochloride
Entry
D01022                      Drug                                   
Name
Oxymetazoline hydrochloride (JAN/USP);
Ocuclear (TN);
Rhfade (TN);
Upneeq (TN)
Product
RHOFADE (EPI Health), RHOFADE (Mayne Pharma), UPNEEQ (RVL Pharmaceuticals)
Formula
C16H24N2O. HCl
Exact mass
296.1655
Mol weight
296.83
Structure
Simcomp
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
Remark
Therapeutic category: 1319
ATC code: D11AX27 R01AA05 R01AB07 S01GA04
Chemical structure group: DG01029
Product (DG01029): D01022<JP/US>
Efficacy
Muscle contraction agent, Vasoconstrictor, alpha1-Adrenergic receptor agonist
Comment
Imidazoline derivative
Target
ADRA1A [HSA:148] [KO:K04135]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX27 Oxymetazoline
      D01022  Oxymetazoline hydrochloride (JAN/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA05 Oxymetazoline
      D01022  Oxymetazoline hydrochloride (JAN/USP) <JP/US>
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB07 Oxymetazoline
      D01022  Oxymetazoline hydrochloride (JAN/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GA Sympathomimetics used as decongestants
     S01GA04 Oxymetazoline
      D01022  Oxymetazoline hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Acne and Rosacea Agents
   Acne and Rosacea Agents, Other
    Oxymetazoline
     D01022  Oxymetazoline hydrochloride (JAN/USP)
 Ophthalmic Agents
  Ophthalmic Agents, Other
   Oxymetazoline
    D01022  Oxymetazoline hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01022  Oxymetazoline hydrochloride (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for otolaryngologic use
  70 Nasal sprays for inflammation
   D01022  Oxymetazoline hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Oxymetazoline
    D01022  Oxymetazoline hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01448  alpha1-Adrenergic receptor agonist
     DG01029  Oxymetazoline
      D01022  Oxymetazoline hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1A
     D01022  Oxymetazoline hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01022
Rx-to-OTC switch list in the USA [br08315.html]
 D01022
Rx-to-OTC switch list in Japan [br08314.html]
 D01022
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01448  alpha1-Adrenergic receptor agonist
     DG01029  Oxymetazoline
Other DBs
CAS: 2315-02-8
PubChem: 7848085
ChEBI: 7863
LigandBox: D01022
J-GLOBAL: J533.812C
LinkDB
KCF data

ATOM        20
            1   X   Cl   27.5100  -25.9000
            2   C8y C    21.1400  -21.2100
            3   C8y C    21.1400  -22.6100
            4   C8y C    22.3524  -23.3100
            5   C8x C    23.5649  -22.6100
            6   C8y C    23.5649  -21.2100
            7   C8y C    22.3524  -20.5100
            8   C1b C    22.3524  -19.1102
            9   C2y C    23.5480  -18.4198
            10  N1x N    24.8536  -18.8359
            11  C1x C    25.6555  -17.7246
            12  C1x C    24.8464  -16.6186
            13  N2x N    23.5444  -17.0463
            14  C1a C    24.7960  -20.4990
            15  C1a C    19.9276  -20.5100
            16  O1a O    19.9276  -23.3100
            17  C1d C    22.3524  -24.7098
            18  C1a C    23.7524  -24.7098
            19  C1a C    20.9524  -24.7098
            20  C1a C    22.3524  -26.1098
BOND        20
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13    9  13 2
            14    6  14 1
            15    2  15 1
            16    3  16 1
            17    4  17 1
            18   17  18 1
            19   17  19 1
            20   17  20 1

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