| Entry |
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| Name |
Loxoprofen sodium hydrate (JP18);
Lorfenamin (TN);
Loxonin (TN) |
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| Formula |
C15H17O3. 2H2O. Na
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| Exact mass |
304.1287
|
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| Mol weight |
304.314
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
|
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| Remark |
| Product (DG01251): | D01709<JP> |
|
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| Efficacy |
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
|---|
| Comment |
Propionic acid derivative
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| Target |
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| Pathway |
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA31 Loxoprofen
D01709 Loxoprofen sodium hydrate (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1149 Others
D01709 Loxoprofen sodium hydrate (JP18)
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2649 Others
D01709 Loxoprofen sodium hydrate (JP18)
Classification of Japanese OTC drugs [BR:br08313]
Agents for nervous and sensory systems
03 Antipyretic analgesic agents
D01709 Loxoprofen sodium hydrate (JP18)
Risk category of Japanese OTC drugs [BR:br08312]
Drugs requiring guidance
New approved switch OTC drugs
Loxoprofen sodium hydrate, d-chlorpheniramine maleate, dihydrocodeine phosphate, dl-methylephedrine hydrochloride, guaifenesin and caffeine
D01709 Loxoprofen sodium hydrate (JP18)
Loxoprofen sodium hydrate, bromhexine hydrochloride, clemastine fumarate, dihydrocodeine phosphate and dl-methylephedrine hydrochloride
D01709 Loxoprofen sodium hydrate (JP18)
Loxoprofen sodium hydrate, mequitazine, L-carbocisteine and tipepidine hibenzate
D01709 Loxoprofen sodium hydrate (JP18)
First-class OTC drugs
Inorganic and organic chemicals
Loxoprofen
D01709 Loxoprofen sodium hydrate (JP18)
Second-class OTC drugs
Inorganic and organic chemicals
Loxoprofen
D01709 Loxoprofen sodium hydrate (JP18)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG01251 Loxoprofen
D01709 Loxoprofen sodium hydrate
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D01709 Loxoprofen sodium hydrate
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D01709 Loxoprofen sodium hydrate (JP18) <JP>
PTGS2 (COX2)
D01709 Loxoprofen sodium hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01709 Loxoprofen sodium hydrate
D01709 Loxoprofen sodium tablets
Rx-to-OTC switch list in Japan [br08314.html]
D01709
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG01251 Loxoprofen
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 21
1 Z Na 36.0934 -14.4362 #+
2 O0 O 40.3165 -16.1141
3 C8y C 28.4875 -16.4943
4 C8x C 29.6970 -17.1967
5 C8x C 30.8451 -16.4964
6 C8y C 30.8710 -15.0910
7 C8x C 29.7023 -14.3861
8 C8x C 28.4839 -15.0864
9 C1c C 32.1364 -14.3908
10 C6a C 33.3521 -15.0956
11 C1a C 32.1390 -12.9854
12 O6a O 34.5705 -14.3954 #-
13 O6a O 33.3263 -16.4541
14 C1x C 26.0590 -15.0926
15 C1y C 26.0627 -16.5005
16 C1b C 27.2769 -17.1974
17 C1x C 24.7189 -14.6610
18 C1x C 23.8943 -15.8021
19 C5x C 24.7248 -16.9390
20 O5x O 24.2939 -18.2767
21 O0 O 40.3165 -16.1141
BOND 19
1 3 4 2
2 4 5 1
3 5 6 2
4 6 7 1
5 7 8 2
6 8 3 1
7 6 9 1
8 9 10 1
9 9 11 1
10 10 12 1
11 10 13 2
12 14 15 1
13 15 16 1
14 3 16 1
15 14 17 1
16 17 18 1
17 18 19 1
18 15 19 1
19 19 20 2
BRACKET 1 38.2900 -17.0800 38.2900 -15.2600
1 41.0200 -15.2600 41.0200 -17.0800
1 2
ORIGINAL 1 2
REPEAT 1 21
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