KEGG   DRUG: Idarubicin hydrochlorideHelp
Entry
D01747                      Drug                                   

Name
Idarubicin hydrochloride (JP17/USP);
Idamycin (TN)
Product
  Generic
Formula
C26H27NO9. HCl
Exact mass
533.1453
Mol weight
533.9548
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antineoplastic
 DG01682  Anthracycline antineoplastic
Other
 DG01529  Topoisomerase inhibitor
  DG01527  Topoisomerase II inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Efficacy
Antineoplastic, Topoisomerase II inhibitor
  Disease
Acute myeloid leukemia [DS:H00003]
Target
TOP2 [HSA:7153 7155] [KO:K03164]
Interaction
Drug interaction
Structure map
Antineoplastics - agents from natural products
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
    L01DB Anthracyclines and related substances
     L01DB06 Idarubicin
      D01747  Idarubicin hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   423  Antibiotics
    4235  Anthracycline antibiotics
     D01747  Idarubicin hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases
   RNA polymerase
    Idarubicin
     D01747  Idarubicin hydrochloride (JP17/USP)
   DNA polymerase
    Idarubicin
     D01747  Idarubicin hydrochloride (JP17/USP)
  Isomerases
   topoisomerase II
    Idarubicin
     D01747  Idarubicin hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01747  Idarubicin hydrochloride
  D01747  Idarubicin hydrochloride for injection
Antineoplastics [br08340.html]
 D01747
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D01747
BRITE hierarchy
Other DBs
CAS: 
57852-57-0
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        37
            1   X   Cl   38.2200  -13.1600
            2   C8x C    22.4700  -11.7600
            3   C8x C    22.4700  -13.1600
            4   C8x C    23.6600  -13.8600
            5   C8y C    24.9200  -13.1600
            6   C8y C    24.9200  -11.7600
            7   C8x C    23.6600  -11.0600
            8   C5x C    26.1100  -13.8600
            9   C8y C    27.3000  -13.1600
            10  C8y C    27.3000  -11.7600
            11  C5x C    26.1100  -11.0600
            12  C8y C    28.5600  -13.8600
            13  C8y C    29.7500  -13.1600
            14  C8y C    29.7500  -11.7600
            15  C8y C    28.5600  -11.0600
            16  C1y C    30.9400  -13.8600
            17  C1x C    32.2000  -13.1600
            18  C1z C    32.2000  -11.7600
            19  C1x C    30.9400  -11.0600
            20  O5x O    26.1100   -9.6600
            21  O5x O    26.1100  -15.2600
            22  O1a O    28.5600   -9.6600
            23  O1a O    28.5600  -15.2600
            24  C5a C    33.3900  -10.8500
            25  C1a C    34.5800  -11.5500
            26  O5a O    33.3900   -9.4500
            27  O1a O    33.3900  -12.6000
            28  O2a O    30.9400  -15.2600
            29  C1y C    32.1300  -15.9600
            30  C1x C    32.1300  -17.3600
            31  C1y C    33.3900  -18.0600
            32  C1y C    34.5800  -17.3600
            33  C1y C    34.5800  -15.9600
            34  O2x O    33.3900  -15.2600
            35  C1a C    35.7700  -15.2600
            36  O1a O    35.7700  -18.0600
            37  N1a N    33.3900  -19.4600
BOND        40
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11    6  11 1
            12    9  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   10  15 2
            17   13  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22   11  20 2
            23    8  21 2
            24   15  22 1
            25   12  23 1
            26   18  24 1 #Up
            27   24  25 1
            28   24  26 2
            29   18  27 1 #Down
            30   16  28 1 #Down
            31   29  28 1 #Down
            32   29  30 1
            33   30  31 1
            34   31  32 1
            35   32  33 1
            36   33  34 1
            37   29  34 1
            38   33  35 1 #Up
            39   32  36 1 #Up
            40   31  37 1 #Up

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