Entry |
|
Name |
Rosuvastatin calcium (JAN/USAN);
ZD 4522;
Crestor (TN)
|
Product |
CRESTOR (A-S Medication Solutions), CRESTOR (Aphena Pharma Solutions - Tennessee), CRESTOR (AstraZeneca Pharmaceuticals LP), CRESTOR (Avera McKennan Hospital), CRESTOR (Bryant Ranch Prepack), CRESTOR (Bryant Ranch Prepack), CRESTOR (Bryant Ranch Prepack), CRESTOR (Bryant Ranch Prepack), CRESTOR (Cardinal Health), CRESTOR (Cardinal Health), CRESTOR (Cardinal Health), CRESTOR (Carilion Materials Management), CRESTOR (H.J. Harkins Company), CRESTOR (Lake Erie Medical & Surgucal Supply DBA Quality Care Products LLC), CRESTOR (Lake Erie Medical DBA Quality Care Products LLC), CRESTOR (PD-Rx Pharmaceuticals), CRESTOR (PD-Rx Pharmaceuticals), CRESTOR (Physicians Total Care), CRESTOR (Rebel Distributors Corp) |
Generic |
ROSUVASTATIN (Camber Pharmaceuticals), ROSUVASTATIN (Lake Erie Medical DBA Quality Care Products LLC), ROSUVASTATIN (REMEDYREPACK), ROSUVASTATIN CALCIUM (Accord Healthcare), ROSUVASTATIN CALCIUM (Actavis Pharma), ROSUVASTATIN CALCIUM (Aidarex Pharmaceuticals LLC), ROSUVASTATIN CALCIUM (American Health Packaging), ROSUVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ROSUVASTATIN (Apotex Corp.), ROSUVASTATIN (Apotex Corp.), ROSUVASTATIN CALCIUM (Ascend Laboratories), ROSUVASTATIN CALCIUM (Aurobindo Pharma Limited), ROSUVASTATIN CALCIUM (AvKARE), ROSUVASTATIN CALCIUM (Avera McKennan Hospital), ROSUVASTATIN CALCIUM (Biocon Pharma), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Cadila Pharmaceuticals Limited), ROSUVASTATIN CALCIUM (Glenmark Pharmaceutials), ROSUVASTATIN CALCIUM (H. J. Harkins Company), ROSUVASTATIN CALCIUM (H. J. Harkins Company), ROSUVASTATIN CALCIUM (Jubilant Cadista Pharmaceuticals), ROSUVASTATIN CALCIUM (LUCID PHARMA LLC), ROSUVASTATIN CALCIUM (Lake Erie Medical DBA Quality Care Products LLC), ROSUVASTATIN CALCIUM (Lake Erie Medical DBA Quality Care Products LLC), ROSUVASTATIN CALCIUM (MSN LABORATORIES PRIVATE LIMITED), ROSUVASTATIN CALCIUM (Major Pharmaceuticals), ROSUVASTATIN CALCIUM (Mylan Institutional), ROSUVASTATIN CALCIUM (Mylan Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (Par Pharmaceutical), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals Incl), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (Rising Health), ROSUVASTATIN CALCIUM (Sandoz), ROSUVASTATIN CALCIUM (Sun Pharma Global FZE), ROSUVASTATIN CALCIUM (Teva Pharmaceuticals USA), ROSUVASTATIN CALCIUM (Torrent Pharmaceuticals Limited), ROSUVASTATIN CALCIUM (Tris Pharma), ROSUVASTATIN CALCIUM (Unit Dose Services) |
Formula |
(C22H27FN3O6S)2. Ca
|
Exact mass |
1000.2835
|
Mol weight |
1001.1374
|
Structure |

     |
Class |
Cardiovascular agent
DG01660 HMG-CoA reductase inhibitor
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
Transporter substrate
DG01913 BCRP substrate
|
Remark |
Therapeutic category: ATC code: Chemical structure group: Product in DG00357: |
Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
Disease |
Hypertriglyceridemia [DS: H01635 H01637] Primary dysbetalipoproteinemia; type III hyperlipoproteinemia [DS: H01637] Homozygous familial hypercholesterolemia [DS: H00155] |
Target |
|
Pathway |
| Terpenoid backbone biosynthesis |
|
Metabolism |
Transporter: SLCO1B1 [HSA: 10599], ABCG2 [HSA: 9429]
|
Interaction |
|
Structure map |
| HMG-CoA reductase inhibitors |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA07 Rosuvastatin
D01915 Rosuvastatin calcium (JAN/USAN)
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, HMG CoA Reductase Inhibitors
Rosuvastatin
D01915 Rosuvastatin calcium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
218 Hyperlipidemia agents
2189 Others
D01915 Rosuvastatin calcium (JAN/USAN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
Rosuvastatin
D01915 Rosuvastatin calcium (JAN/USAN)
Drug classes of therapeutic agents [br08360.html]
Hypolipidemic agents
D01915
New drug approvals in the USA [br08319.html]
New Molecular Entity and New Therapeutic Biological Product Approvals
D01915
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01915
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D01915
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
Polymorphisms and germline mutations
D01915
 |
Other DBs |
CAS: 147098-20-2 PubChem: ChEBI: ChEMBL: DrugBank: LigandBox: |
LinkDB |
 |
KCF data |
 ATOM 67
1 C8y C 24.4367 -20.6549
2 N5x N 24.4367 -22.0555
3 C8y C 25.6498 -22.7558
4 N5x N 26.8627 -22.0555
5 C8y C 26.8627 -20.6549
6 C8y C 25.6498 -19.9546
7 C1c C 28.0770 -19.9538
8 C1a C 29.2913 -20.6549
9 C1a C 28.0770 -18.5540
10 C2b C 25.6498 -18.5540
11 C2b C 26.8634 -17.8533
12 C1c C 26.8634 -16.4531
13 O1a O 28.0772 -15.7523
14 C1b C 25.6513 -15.7533
15 C1c C 25.6507 -14.3522
16 O1a O 24.4373 -13.6524
17 C1b C 26.8633 -13.6514
18 C6a C 28.2651 -13.6519
19 O6a O 28.9659 -12.4392
20 O6a O 28.9649 -14.8651 #-
21 N1c N 25.6498 -24.1565
22 S4a S 26.8634 -24.8572
23 C1a C 24.4374 -24.8564
24 C1a C 28.0773 -24.1563
25 O3c O 25.8841 -25.8373
26 O3c O 27.8449 -25.8373
27 C8y C 23.2238 -19.9546
28 C8x C 23.2238 -18.5540
29 C8x C 22.0108 -17.8537
30 C8y C 20.7978 -18.5540
31 C8x C 20.7978 -19.9546
32 C8x C 22.0108 -20.6549
33 X F 19.5828 -17.8525
34 Z Ca 33.4941 -14.9124 #2+
35 C8y C 24.4367 -20.6549
36 N5x N 24.4367 -22.0555
37 C8y C 25.6498 -22.7558
38 N5x N 26.8627 -22.0555
39 C8y C 26.8627 -20.6549
40 C8y C 25.6498 -19.9546
41 C2b C 25.6498 -18.5540
42 C2b C 26.8634 -17.8533
43 C1c C 26.8634 -16.4531
44 O1a O 28.0772 -15.7523
45 C1b C 25.6513 -15.7533
46 C1c C 25.6507 -14.3522
47 O1a O 24.4373 -13.6524
48 C1b C 26.8633 -13.6514
49 C6a C 28.2651 -13.6519
50 O6a O 28.9659 -12.4392
51 O6a O 28.9649 -14.8651 #-
52 C1c C 28.0770 -19.9538
53 C1a C 29.2913 -20.6549
54 C1a C 28.0770 -18.5540
55 N1c N 25.6498 -24.1565
56 S4a S 26.8634 -24.8572
57 C1a C 28.0773 -24.1563
58 O3c O 25.8841 -25.8373
59 O3c O 27.8449 -25.8373
60 C1a C 24.4374 -24.8564
61 C8y C 23.2238 -19.9546
62 C8x C 23.2238 -18.5540
63 C8x C 22.0108 -17.8537
64 C8y C 20.7978 -18.5540
65 C8x C 20.7978 -19.9546
66 C8x C 22.0108 -20.6549
67 X F 19.5828 -17.8525
BOND 68
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 7 9 1
10 6 10 1
11 10 11 2
12 12 11 1 #Down
13 12 13 1
14 12 14 1
15 14 15 1
16 15 16 1 #Up
17 15 17 1
18 17 18 1
19 18 19 2
20 18 20 1
21 3 21 1
22 21 22 1
23 21 23 1
24 22 24 1
25 22 25 2
26 22 26 2
27 1 27 1
28 27 28 2
29 28 29 1
30 29 30 2
31 30 31 1
32 31 32 2
33 27 32 1
34 30 33 1
35 35 36 2
36 36 37 1
37 37 38 2
38 38 39 1
39 39 40 2
40 35 40 1
41 39 52 1
42 52 53 1
43 52 54 1
44 40 41 1
45 41 42 2
46 43 42 1 #Down
47 43 44 1
48 43 45 1
49 45 46 1
50 46 47 1 #Up
51 46 48 1
52 48 49 1
53 49 50 2
54 49 51 1
55 37 55 1
56 55 56 1
57 55 60 1
58 56 57 1
59 56 58 2
60 56 59 2
61 35 61 1
62 61 62 2
63 62 63 1
64 63 64 2
65 64 65 1
66 65 66 2
67 61 66 1
68 64 67 1
BRACKET 1 18.4100 -26.5300 18.4100 -11.4100
1 31.4300 -11.4100 31.4300 -26.5300
1 2
ORIGINAL 1 1 2 3 4 5 6 10 11 12 13 14 15 16 17 18 19
1 20 7 8 9 21 22 24 25 26 23 27 28 29 30 31 32
1 33
REPEAT 1 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50
1 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66
1 67
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