| Entry |
|
|---|
| Name |
Rosuvastatin calcium (JAN/USAN);
ZD 4522;
Crestor (TN)
|
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| Product |
CRESTOR (A-S Medication Solutions LLC), CRESTOR (Aphena Pharma Solutions - Tennessee), CRESTOR (AstraZeneca Pharmaceuticals LP), CRESTOR (Bryant Ranch Prepack), CRESTOR (Bryant Ranch Prepack), CRESTOR (Bryant Ranch Prepack), CRESTOR (Cardinal Health), CRESTOR (Cardinal Health), CRESTOR (Cardinal Health), CRESTOR (Carilion Materials Management), CRESTOR (H.J. Harkins Company), CRESTOR (Lake Erie Medical & Surgucal Supply DBA Quality Care Products LLC), CRESTOR (Lake Erie Medical DBA Quality Care Products LLC), CRESTOR (PD-Rx Pharmaceuticals), CRESTOR (PD-Rx Pharmaceuticals), CRESTOR (Physicians Total Care), CRESTOR (REMEDYREPACK), CRESTOR (Rebel Distributors Corp) |
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| Formula |
(C22H27FN3O6S)2. Ca
|
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| Exact mass |
1000.2835
|
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| Mol weight |
1001.1374
|
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| Structure |
     |
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| Activity |
Antihyperlipidemic [HMGCoA reductase inhibitor]
|
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| Remark |
Therapeutic category: ATC code: Drug group: |
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| Target |
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor [HSA: 3156] [KO: K00021] |
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| Pathway |
hsa00900 Terpenoid backbone biosynthesis | |
|
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| Metabolism |
Transporter: ABCG2 [HSA: 9429], SLCO1B1 [HSA: 10599], SLCO1B3 [HSA: 28234], SLC22A8 [HSA: 9376]
|
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| Interaction |
Genomic biomarker: LDLR [HSA: 3949]
 |
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| Structure map |
| HMG-CoA reductase inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA07 Rosuvastatin
D01915 Rosuvastatin calcium (JAN/USAN)
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, HMG CoA Reductase Inhibitors
Rosuvastatin
D01915 Rosuvastatin calcium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
218 Hyperlipidemia agents
2189 Others
D01915 Rosuvastatin calcium (JAN/USAN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
Rosuvastatin
D01915 Rosuvastatin calcium (JAN/USAN)
 |
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| Other DBs |
CAS: 147098-20-2 PubChem: DrugBank: LigandBox: |
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| LinkDB |
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| KCF data |
ATOM 67
1 C8y C 24.4367 -20.6549
2 N5x N 24.4367 -22.0555
3 C8y C 25.6498 -22.7558
4 N5x N 26.8627 -22.0555
5 C8y C 26.8627 -20.6549
6 C8y C 25.6498 -19.9546
7 C1c C 28.0770 -19.9538
8 C1a C 29.2913 -20.6549
9 C1a C 28.0770 -18.5540
10 C2b C 25.6498 -18.5540
11 C2b C 26.8634 -17.8533
12 C1c C 26.8634 -16.4531
13 O1a O 28.0772 -15.7523
14 C1b C 25.6513 -15.7533
15 C1c C 25.6507 -14.3522
16 O1a O 24.4373 -13.6524
17 C1b C 26.8633 -13.6514
18 C6a C 28.2651 -13.6519
19 O6a O 28.9659 -12.4392
20 O6a O 28.9649 -14.8651 #-
21 N1c N 25.6498 -24.1565
22 S4a S 26.8634 -24.8572
23 C1a C 24.4374 -24.8564
24 C1a C 28.0773 -24.1563
25 O3c O 25.8841 -25.8373
26 O3c O 27.8449 -25.8373
27 C8y C 23.2238 -19.9546
28 C8x C 23.2238 -18.5540
29 C8x C 22.0108 -17.8537
30 C8y C 20.7978 -18.5540
31 C8x C 20.7978 -19.9546
32 C8x C 22.0108 -20.6549
33 X F 19.5828 -17.8525
34 Z Ca 33.4941 -14.9124 #2+
35 C8y C 24.4367 -20.6549
36 N5x N 24.4367 -22.0555
37 C8y C 25.6498 -22.7558
38 N5x N 26.8627 -22.0555
39 C8y C 26.8627 -20.6549
40 C8y C 25.6498 -19.9546
41 C2b C 25.6498 -18.5540
42 C2b C 26.8634 -17.8533
43 C1c C 26.8634 -16.4531
44 O1a O 28.0772 -15.7523
45 C1b C 25.6513 -15.7533
46 C1c C 25.6507 -14.3522
47 O1a O 24.4373 -13.6524
48 C1b C 26.8633 -13.6514
49 C6a C 28.2651 -13.6519
50 O6a O 28.9659 -12.4392
51 O6a O 28.9649 -14.8651 #-
52 C1c C 28.0770 -19.9538
53 C1a C 29.2913 -20.6549
54 C1a C 28.0770 -18.5540
55 N1c N 25.6498 -24.1565
56 S4a S 26.8634 -24.8572
57 C1a C 28.0773 -24.1563
58 O3c O 25.8841 -25.8373
59 O3c O 27.8449 -25.8373
60 C1a C 24.4374 -24.8564
61 C8y C 23.2238 -19.9546
62 C8x C 23.2238 -18.5540
63 C8x C 22.0108 -17.8537
64 C8y C 20.7978 -18.5540
65 C8x C 20.7978 -19.9546
66 C8x C 22.0108 -20.6549
67 X F 19.5828 -17.8525
BOND 68
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 7 9 1
10 6 10 1
11 10 11 2
12 12 11 1 #Down
13 12 13 1
14 12 14 1
15 14 15 1
16 15 16 1 #Up
17 15 17 1
18 17 18 1
19 18 19 2
20 18 20 1
21 3 21 1
22 21 22 1
23 21 23 1
24 22 24 1
25 22 25 2
26 22 26 2
27 1 27 1
28 27 28 2
29 28 29 1
30 29 30 2
31 30 31 1
32 31 32 2
33 27 32 1
34 30 33 1
35 35 36 2
36 36 37 1
37 37 38 2
38 38 39 1
39 39 40 2
40 35 40 1
41 39 52 1
42 52 53 1
43 52 54 1
44 40 41 1
45 41 42 2
46 43 42 1 #Down
47 43 44 1
48 43 45 1
49 45 46 1
50 46 47 1 #Up
51 46 48 1
52 48 49 1
53 49 50 2
54 49 51 1
55 37 55 1
56 55 56 1
57 55 60 1
58 56 57 1
59 56 58 2
60 56 59 2
61 35 61 1
62 61 62 2
63 62 63 1
64 63 64 2
65 64 65 1
66 65 66 2
67 61 66 1
68 64 67 1
BRACKET 1 18.4100 -26.5300 18.4100 -11.4100
1 31.4300 -11.4100 31.4300 -26.5300
1 2
ORIGINAL 1 1 2 3 4 5 6 10 11 12 13 14 15 16 17 18 19
1 20 7 8 9 21 22 24 25 26 23 27 28 29 30 31 32
1 33
REPEAT 1 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50
1 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66
1 67
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