KEGG   DRUG: Rosuvastatin calciumHelp
Entry
D01915                      Drug                                   

Name
Rosuvastatin calcium (JAN/USAN);
ZD 4522;
Crestor (TN)
Product
  Generic
ROSUVASTATIN (Camber Pharmaceuticals), ROSUVASTATIN CALCIUM (Accord Healthcare), ROSUVASTATIN CALCIUM (Actavis Pharma), ROSUVASTATIN CALCIUM (American Health Packaging), ROSUVASTATIN (Apotex Corp.), ROSUVASTATIN CALCIUM (Aurobindo Pharma Limited), ROSUVASTATIN CALCIUM (AvKARE), ROSUVASTATIN CALCIUM (Biocon Pharma), ROSUVASTATIN CALCIUM (Citron Pharma LLC), ROSUVASTATIN CALCIUM (Glenmark Pharmaceutials), ROSUVASTATIN (Golden State Medical Supply), ROSUVASTATIN CALCIUM (Jubilant Cadista Pharmaceuticals), ROSUVASTATIN CALCIUM (Major Pharmaceuticals), ROSUVASTATIN CALCIUM (Mylan Institutional), ROSUVASTATIN CALCIUM (Mylan Pharmaceuticals), ROSUVASTATIN CALCIUM (Par Pharmaceutical), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals Incl), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (Sandoz), ROSUVASTATIN CALCIUM (Sun Pharma Global FZE), ROSUVASTATIN CALCIUM (Teva Pharmaceuticals USA), ROSUVASTATIN CALCIUM (Torrent Pharmaceuticals Limited)
Formula
(C22H27FN3O6S)2. Ca
Exact mass
1000.2835
Mol weight
1001.1374
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01660  HMG-CoA reductase inhibitor
  DG01660  HMG-CoA reductase inhibitor
Transporter substrate
 DG01913  BCRP substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antihyperlipidemic, HMGCoA reductase inhibitor
  Disease
Hypertriglyceridemia [DS:H01637]
Primary dysbetalipoproteinemia (Type III hyperlipoproteinemia) [DS:H01637]
Homozygous familial hypercholesterolemia [DS:H00155 H01383]
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
Transporter: ABCG2 [HSA:9429], SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234], SLC22A8 [HSA:9376]
Interaction
Genomic biomarker: LDLR [HSA:3949]
Drug interaction
Structure map
HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA07 Rosuvastatin
      D01915  Rosuvastatin calcium (JAN/USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Rosuvastatin
    D01915  Rosuvastatin calcium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D01915  Rosuvastatin calcium (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
    Rosuvastatin
     D01915  Rosuvastatin calcium (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A
   Rosuvastatin
    D01915  Rosuvastatin calcium (JAN/USAN)
 Transporter substrates
  ABCG2
   Rosuvastatin
    D01915  Rosuvastatin calcium (JAN/USAN)
  OAT3
   Rosuvastatin
    D01915  Rosuvastatin calcium (JAN/USAN)
  SLCO1B1
   Rosuvastatin
    D01915  Rosuvastatin calcium (JAN/USAN)
  SLCO1B3
   Rosuvastatin
    D01915  Rosuvastatin calcium (JAN/USAN)
Hypolipidemic agents [br08365.html]
 D01915
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01915
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01915
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01915
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D01915
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D01915
BRITE hierarchy
Other DBs
CAS: 
147098-20-2
PubChem: 
DrugBank: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        67
            1   C8y C    24.4367  -20.6549
            2   N5x N    24.4367  -22.0555
            3   C8y C    25.6498  -22.7558
            4   N5x N    26.8627  -22.0555
            5   C8y C    26.8627  -20.6549
            6   C8y C    25.6498  -19.9546
            7   C1c C    28.0770  -19.9538
            8   C1a C    29.2913  -20.6549
            9   C1a C    28.0770  -18.5540
            10  C2b C    25.6498  -18.5540
            11  C2b C    26.8634  -17.8533
            12  C1c C    26.8634  -16.4531
            13  O1a O    28.0772  -15.7523
            14  C1b C    25.6513  -15.7533
            15  C1c C    25.6507  -14.3522
            16  O1a O    24.4373  -13.6524
            17  C1b C    26.8633  -13.6514
            18  C6a C    28.2651  -13.6519
            19  O6a O    28.9659  -12.4392
            20  O6a O    28.9649  -14.8651 #-
            21  N1c N    25.6498  -24.1565
            22  S4a S    26.8634  -24.8572
            23  C1a C    24.4374  -24.8564
            24  C1a C    28.0773  -24.1563
            25  O3c O    25.8841  -25.8373
            26  O3c O    27.8449  -25.8373
            27  C8y C    23.2238  -19.9546
            28  C8x C    23.2238  -18.5540
            29  C8x C    22.0108  -17.8537
            30  C8y C    20.7978  -18.5540
            31  C8x C    20.7978  -19.9546
            32  C8x C    22.0108  -20.6549
            33  X   F    19.5828  -17.8525
            34  Z   Ca   33.4941  -14.9124 #2+
            35  C8y C    24.4367  -20.6549
            36  N5x N    24.4367  -22.0555
            37  C8y C    25.6498  -22.7558
            38  N5x N    26.8627  -22.0555
            39  C8y C    26.8627  -20.6549
            40  C8y C    25.6498  -19.9546
            41  C2b C    25.6498  -18.5540
            42  C2b C    26.8634  -17.8533
            43  C1c C    26.8634  -16.4531
            44  O1a O    28.0772  -15.7523
            45  C1b C    25.6513  -15.7533
            46  C1c C    25.6507  -14.3522
            47  O1a O    24.4373  -13.6524
            48  C1b C    26.8633  -13.6514
            49  C6a C    28.2651  -13.6519
            50  O6a O    28.9659  -12.4392
            51  O6a O    28.9649  -14.8651 #-
            52  C1c C    28.0770  -19.9538
            53  C1a C    29.2913  -20.6549
            54  C1a C    28.0770  -18.5540
            55  N1c N    25.6498  -24.1565
            56  S4a S    26.8634  -24.8572
            57  C1a C    28.0773  -24.1563
            58  O3c O    25.8841  -25.8373
            59  O3c O    27.8449  -25.8373
            60  C1a C    24.4374  -24.8564
            61  C8y C    23.2238  -19.9546
            62  C8x C    23.2238  -18.5540
            63  C8x C    22.0108  -17.8537
            64  C8y C    20.7978  -18.5540
            65  C8x C    20.7978  -19.9546
            66  C8x C    22.0108  -20.6549
            67  X   F    19.5828  -17.8525
BOND        68
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 1
            10    6  10 1
            11   10  11 2
            12   12  11 1 #Down
            13   12  13 1
            14   12  14 1
            15   14  15 1
            16   15  16 1 #Up
            17   15  17 1
            18   17  18 1
            19   18  19 2
            20   18  20 1
            21    3  21 1
            22   21  22 1
            23   21  23 1
            24   22  24 1
            25   22  25 2
            26   22  26 2
            27    1  27 1
            28   27  28 2
            29   28  29 1
            30   29  30 2
            31   30  31 1
            32   31  32 2
            33   27  32 1
            34   30  33 1
            35   35  36 2
            36   36  37 1
            37   37  38 2
            38   38  39 1
            39   39  40 2
            40   35  40 1
            41   39  52 1
            42   52  53 1
            43   52  54 1
            44   40  41 1
            45   41  42 2
            46   43  42 1 #Down
            47   43  44 1
            48   43  45 1
            49   45  46 1
            50   46  47 1 #Up
            51   46  48 1
            52   48  49 1
            53   49  50 2
            54   49  51 1
            55   37  55 1
            56   55  56 1
            57   55  60 1
            58   56  57 1
            59   56  58 2
            60   56  59 2
            61   35  61 1
            62   61  62 2
            63   62  63 1
            64   63  64 2
            65   64  65 1
            66   65  66 2
            67   61  66 1
            68   64  67 1
BRACKET     1    18.4100  -26.5300   18.4100  -11.4100
            1    31.4300  -11.4100   31.4300  -26.5300
            1  2
 ORIGINAL  1    1   2   3   4   5   6  10  11  12  13  14  15  16  17  18  19
            1   20   7   8   9  21  22  24  25  26  23  27  28  29  30  31  32
            1   33
 REPEAT    1   35  36  37  38  39  40  41  42  43  44  45  46  47  48  49  50
            1   51  52  53  54  55  56  57  58  59  60  61  62  63  64  65  66
            1   67

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