KEGG   DRUG: D02323Help
Entry
D02323                      Drug                                   

Name
Tolrestat (USAN/INN);
Alredase (TN)
Formula
C16H14F3NO3S
Exact mass
357.0646
Mol weight
357.3475
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Inhibitor [aldose reductase] [DS:H00408 H00409]
Remark
Same as: 
ATC code: 
Target
aldose reductase inhibitor [HSA:231] [KO:K00011]
  Pathway
hsa00051  Fructose and mannose metabolism  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10X OTHER DRUGS USED IN DIABETES
    A10XA Aldose reductase inhibitors
     A10XA01 Tolrestat
      D02323  Tolrestat (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   aldose reductase
    Tolrestat
     D02323  Tolrestat (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
82964-04-3
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        24
            1   C8y C    21.4118  -15.8743
            2   C8y C    21.4118  -17.2621
            3   C8y C    22.6160  -15.1643
            4   C8x C    20.2013  -15.1834
            5   C8y C    20.2013  -17.9718
            6   C8x C    22.6287  -17.9657
            7   C8x C    23.8645  -15.8743
            8   C2c C    22.6095  -13.7828
            9   C8x C    19.0036  -15.8743
            10  C8y C    19.0036  -17.2621
            11  C1d C    20.2649  -19.3472
            12  C8x C    23.8919  -17.2686
            13  N1c N    23.8011  -13.0921
            14  S0  S    21.4118  -13.0983
            15  O2a O    17.8121  -17.9465
            16  X   F    19.0736  -20.0317
            17  X   F    21.4564  -20.0381
            18  X   F    20.2460  -20.9011
            19  C1b C    25.3538  -13.9412
            20  C1a C    23.7949  -11.7103
            21  C1a C    16.6206  -17.2559
            22  C6a C    26.5326  -13.2313
            23  O6a O    27.7368  -13.8969
            24  O6a O    26.5412  -11.8498
BOND        25
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 2
            12    8  13 1
            13    8  14 2
            14   10  15 1
            15   11  16 1
            16   11  17 1
            17   11  18 1
            18   13  19 1
            19   13  20 1
            20   15  21 1
            21   19  22 1
            22   22  23 1
            23   22  24 2
            24    7  12 1
            25    9  10 1

» Japanese version   » Back

DBGET integrated database retrieval system