| Entry |
|
|---|
| Name |
Limaprost alfadex (JP18);
Opalmon (TN) |
|---|
| Formula |
(C36H60O30)x. C22H36O5
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
Hormonal agent
DG01961 Prostaglandin derivative
DG01611 Prostaglandin E1 derivative
|
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| Remark |
| Product (DG01271): | D02860<JP> |
|
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| Efficacy |
Vasodilator, Prostaglandin E1 receptor agonist |
|---|
| Comment |
Prostaglandin E1 derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Interaction |
|
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| Structure map |
| map07228 | Eicosanoid receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B01 ANTITHROMBOTIC AGENTS
B01A ANTITHROMBOTIC AGENTS
B01AC Platelet aggregation inhibitors excl. heparin
B01AC28 Limaprost
D02860 Limaprost alfadex (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
219 Miscellaneous
2190 Miscellaneous
D02860 Limaprost alfadex (JP18)
3 Agents affecting metabolism
33 Blood and body fluid agents
339 Miscellaneous
3399 Others
D02860 Limaprost alfadex (JP18)
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01271 Limaprost
D02860 Limaprost alfadex
Hormonal agent
DG01961 Prostaglandin derivative
DG01611 Prostaglandin E1 derivative
DG01271 Limaprost
D02860 Limaprost alfadex
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Prostaglandin
PTGER1
D02860 Limaprost alfadex (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02860 Limaprost alfadex
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01271 Limaprost
Hormonal agent
DG01961 Prostaglandin derivative
DG01611 Prostaglandin E1 derivative
DG01271 Limaprost
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 93
1 C1y C 7.8056 -15.5840
2 C1y C 7.8056 -14.1803
3 C5x C 6.4721 -13.7592
4 C1x C 5.6299 -14.8821
5 C1y C 6.4721 -16.0051
6 O5x O 6.0510 -12.4258
7 O1a O 6.0510 -17.3385
8 C1b C 8.9987 -13.4785
9 C1b C 10.2620 -14.1803
10 C1b C 11.4551 -13.4785
11 C1b C 12.6482 -14.1803
12 C2b C 13.9114 -13.4785
13 C2b C 15.1045 -14.1803
14 C6a C 16.2976 -13.4785
15 O6a O 17.5609 -14.1803
16 C2b C 8.9987 -16.2858
17 C2b C 10.2620 -15.5840
18 C1c C 11.4551 -16.2858
19 C1b C 12.6482 -15.5840
20 C1c C 13.9114 -16.2858
21 C1b C 15.1045 -15.5840
22 C1b C 16.2976 -16.2858
23 C1b C 17.5609 -15.5840
24 C1a C 18.7540 -16.2858
25 O6a O 16.2976 -12.0748
26 O1a O 11.4551 -17.6894
27 C1a C 13.9114 -17.6894
28 C1y C 35.0700 -11.9700
29 C1y C 33.7400 -11.9700
30 O2x O 33.0400 -13.1600
31 C1y C 33.7400 -14.2800
32 C1y C 35.0700 -14.2800
33 C1y C 35.7700 -13.0900
34 O2x O 33.7400 -17.0100
35 C1y C 35.0700 -17.0100
36 O2a O 35.7700 -15.6100
37 C1y C 33.0400 -18.2000
38 C1y C 33.7400 -19.3900
39 C1y C 35.0700 -19.3900
40 C1y C 35.7700 -18.2000
41 O1a O 37.1000 -13.0900
42 O1a O 35.7700 -20.5800
43 O1a O 35.7700 -10.7800
44 O1a O 37.1000 -18.2000
45 O2a O 33.0400 -10.7800
46 C1y C 31.2200 -10.7800
47 C1y C 30.4500 -11.9700
48 O2x O 30.5200 -19.3900
49 C1y C 31.2200 -20.5800
50 O2a O 33.1100 -20.5800
51 C1y C 30.4500 -9.5900
52 C1y C 29.1200 -9.5900
53 C1y C 28.4200 -10.7800
54 O2x O 29.1200 -11.9700
55 C1y C 29.1900 -19.3900
56 C1y C 28.4900 -20.5800
57 C1y C 29.1900 -21.7700
58 C1y C 30.5200 -21.7700
59 O1a O 31.2200 -22.9600
60 O1a O 28.4200 -8.4000
61 O1a O 31.1500 -8.4000
62 O2a O 26.6000 -10.7800
63 O1a O 28.4900 -22.9600
64 O2a O 26.6700 -20.5800
65 O2x O 26.6700 -18.2700
66 C1y C 26.0400 -19.4600
67 C1y C 26.0400 -11.9700
68 C1y C 26.6700 -13.1600
69 C1y C 24.6400 -11.9700
70 C1y C 24.0100 -13.1600
71 C1y C 24.6400 -14.3500
72 O2x O 26.0400 -14.3500
73 C1y C 26.0400 -17.0800
74 C1y C 24.6400 -17.0800
75 C1y C 24.0100 -18.2700
76 C1y C 24.6400 -19.4600
77 O1a O 24.0100 -10.7800
78 O2a O 23.9400 -15.7500
79 O1a O 22.6100 -18.2700
80 O1a O 22.6100 -13.1600
81 O1a O 24.0100 -20.6500
82 C1b C 28.4200 -18.2000
83 C1b C 26.7400 -15.8900
84 C1b C 28.0000 -13.1600
85 C1b C 31.1500 -13.1600
86 C1b C 33.0400 -15.5400
87 C1b C 31.6400 -18.2000
88 O1a O 29.1900 -17.1500
89 O1a O 28.1400 -15.8900
90 O1a O 28.7000 -14.3500
91 O1a O 30.8000 -14.5600
92 O1a O 31.7100 -15.6100
93 O1a O 30.9400 -16.9400
BOND 99
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 1 5 1
6 3 6 2
7 5 7 1 #Down
8 2 8 1 #Down
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 12 13 2
14 13 14 1
15 14 15 1
16 1 16 1 #Up
17 16 17 2
18 17 18 1
19 18 19 1
20 19 20 1
21 20 21 1
22 21 22 1
23 22 23 1
24 23 24 1
25 14 25 2
26 18 26 1 #Down
27 20 27 1 #Down
28 28 29 1
29 29 30 1
30 30 31 1
31 31 32 1
32 32 33 1
33 28 33 1
34 34 35 1
35 35 36 1 #Down
36 32 36 1 #Down
37 34 37 1
38 37 38 1
39 38 39 1
40 39 40 1
41 35 40 1
42 33 41 1 #Up
43 39 42 1 #Up
44 28 43 1 #Down
45 40 44 1 #Down
46 29 45 1 #Down
47 46 45 1 #Down
48 46 47 1
49 49 48 1
50 49 50 1 #Down
51 38 50 1 #Down
52 46 51 1
53 51 52 1
54 52 53 1
55 53 54 1
56 47 54 1
57 48 55 1
58 55 56 1
59 56 57 1
60 57 58 1
61 49 58 1
62 58 59 1 #Down
63 52 60 1 #Down
64 51 61 1 #Up
65 53 62 1 #Down
66 57 63 1 #Up
67 56 64 1 #Down
68 65 66 1
69 66 64 1 #Down
70 67 62 1 #Down
71 67 68 1
72 67 69 1
73 69 70 1
74 70 71 1
75 71 72 1
76 68 72 1
77 65 73 1
78 73 74 1
79 74 75 1
80 75 76 1
81 66 76 1
82 69 77 1 #Up
83 71 78 1 #Down
84 74 78 1 #Down
85 75 79 1 #Up
86 70 80 1 #Down
87 76 81 1 #Down
88 55 82 1 #Up
89 73 83 1 #Up
90 68 84 1 #Up
91 47 85 1 #Up
92 31 86 1 #Up
93 37 87 1 #Up
94 82 88 1
95 83 89 1
96 84 90 1
97 85 91 1
98 86 92 1
99 87 93 1
BRACKET 1 21.0000 -22.5400 21.0000 -7.4200
1 38.0800 -7.4200 38.0800 -22.5400
1 x
ORIGINAL 1 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43
1 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59
1 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75
1 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91
1 92 93
REPEAT 1
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