KEGG   DRUG: CetuximabHelp
Entry
D03455                      Drug                                   

Name
Cetuximab (USAN/INN);
Cetuximab (genetical recombination) (JAN);
Erbitux (TN)
Product
Remark
Therapeutic category: 4291
ATC code: L01XC06
Product: D03455<JP/US>
Efficacy
Antineoplastic, Anti-epidermal growth factor receptor antibody
  Disease
Squamous cell carcinoma [DS:H00040]
Colorectal cancer (K-Ras wild type, EGFR-expressing) [DS:H00020]
Comment
Monoclonal antibody
Target
EGFR [HSA:1956] [KO:K04361]
  Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
Structure map
map07045  Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XC Monoclonal antibodies
     L01XC06 Cetuximab
      D03455  Cetuximab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D03455  Cetuximab (USAN/INN); Cetuximab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class I (EGF receptor family)
    EGFR tyrosine kinase
     Cetuximab
      D03455  Cetuximab (USAN/INN)
 Monoclonal antibodies
  EGFR
   Cetuximab
    D03455  Cetuximab (USAN/INN)
Antineoplastics [br08340.html]
 D03455
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03455
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03455
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03455
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03455
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Companion diagnostics
  D03455
BRITE hierarchy
Other DBs
CAS: 205923-56-4
PubChem: 17397595
DrugBank: DB00002
NIKKAJI: J2.240.829A
LinkDB All DBs

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