KEGG   DRUG: D05091Help
Entry
D05091                      Drug                                   

Name
Muraglitazar (USAN/INN)
Formula
C29H28N2O7
Exact mass
516.1897
Mol weight
516.5418
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of type-2 diabetes mellitus, mixed dyslipidemia, atherosclerosis, and metabolic syndrome [deal (alpha and gamma) peroxisome proliferator activated receptor (PPAR) agonist]
Target
peroxisome proliferator-activated receptor (PPAR) alpha agonist [HSA:5465] [KO:K07294];
peroxisome proliferator-activated receptor (PPAR) gamma agonist [HSA:5468] [KO:K08530]
  Pathway
hsa03320  PPAR signaling pathway
hsa04920  Adipocytokine signaling pathway  
 
Structure map
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) alpha [HSA:5465] [KO:K07294]
     Muraglitazar
      D05091  Muraglitazar (USAN/INN)
    peroxisome proliferator-activated receptor (PPAR) gamma [HSA:5468] [KO:K08530]
     Muraglitazar
      D05091  Muraglitazar (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
331741-94-7
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        38
            1   C8y C    28.4900  -13.7200
            2   C8x C    28.4900  -15.1200
            3   C8x C    27.3000  -15.8200
            4   C8y C    26.0400  -15.1200
            5   C8x C    26.0400  -13.7200
            6   C8x C    27.3000  -13.0200
            7   O2a O    29.6800  -13.0200
            8   C1a C    30.9400  -13.7200
            9   O7a O    24.8500  -15.8200
            10  C7a C    23.6600  -15.1200
            11  O6a O    23.6600  -13.7200
            12  N1c N    22.4000  -15.8200
            13  C1b C    21.2100  -15.1200
            14  O6a O    24.8500  -17.2200
            15  C6a C    23.6600  -17.9200
            16  C1b C    22.4000  -17.2200
            17  O6a O    23.6600  -19.3200
            18  C8y C    20.0200  -15.8200
            19  C8x C    20.0200  -17.2200
            20  C8x C    18.7600  -17.9200
            21  C8y C    17.5700  -17.2200
            22  C8x C    17.5700  -15.8200
            23  C8x C    18.7600  -15.1200
            24  O2a O    16.3800  -17.9200
            25  C1b C    15.1900  -17.2200
            26  C1b C    13.9300  -17.9200
            27  C8y C    12.7400  -17.2200
            28  C8y C    12.7400  -15.8200
            29  C1a C    13.9300  -15.1200
            30  N5x N    11.4100  -17.6400
            31  C8y C    10.5700  -16.5200
            32  O2x O    11.4100  -15.4000
            33  C8y C     9.1700  -16.5200
            34  C8x C     8.4700  -17.7100
            35  C8x C     7.0700  -17.7100
            36  C8x C     6.3700  -16.5200
            37  C8x C     7.0700  -15.3300
            38  C8x C     8.4700  -15.3300
BOND        41
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     4   9 1
            10    9  10 1
            11   10  11 2
            12   10  12 1
            13   12  13 1
            14   14  15 1
            15   15  16 1
            16   12  16 1
            17   15  17 2
            18   13  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   18  23 1
            25   21  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 2
            30   28  29 1
            31   27  30 1
            32   30  31 2
            33   31  32 1
            34   28  32 1
            35   31  33 1
            36   33  34 2
            37   34  35 1
            38   35  36 2
            39   36  37 1
            40   37  38 2
            41   33  38 1

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