KEGG   DRUG: D05091Help
Entry
D05091                      Drug                                   
Name
Muraglitazar (USAN/INN)
Formula
C29H28N2O7
Exact mass
516.1897
Mol weight
516.5418
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of type-2 diabetes mellitus, mixed dyslipidemia, atherosclerosis, and metabolic syndrome [deal (alpha and gamma) peroxisome proliferator activated receptor (PPAR) agonist]
Target
peroxisome proliferator-activated receptor (PPAR) alpha agonist [HSA:5465] [KO:K07294];
peroxisome proliferator-activated receptor (PPAR) gamma agonist [HSA:5468] [KO:K08530]
  Pathway
hsa03320  PPAR signaling pathway
hsa04920  Adipocytokine signaling pathway  
 
Structure map
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) alpha [HSA:5465] [KO:K07294]
     Muraglitazar
      D05091  Muraglitazar (USAN/INN)
    peroxisome proliferator-activated receptor (PPAR) gamma [HSA:5468] [KO:K08530]
     Muraglitazar
      D05091  Muraglitazar (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
331741-94-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        38
            1   C8y C    17.7100   -7.4200
            2   C8x C    17.7100   -8.8200
            3   C8x C    18.9224   -9.5200
            4   C8y C    20.1349   -8.8200
            5   C8x C    20.1349   -7.4200
            6   C8x C    18.9224   -6.7200
            7   O2a O    16.4976   -6.7200
            8   C1a C    15.2851   -7.4200
            9   O7a O    21.3473   -9.5200
            10  C7a C    22.5597   -8.8200
            11  O6a O    22.5597   -7.4200
            12  N1c N    23.7722   -9.5200
            13  C1b C    24.9846   -8.8200
            14  O6a O    21.3473  -10.9200
            15  C6a C    22.5597  -11.6200
            16  C1b C    23.7722  -10.9200
            17  O6a O    22.5597  -13.0199
            18  C8y C    26.1970   -9.5200
            19  C8x C    26.1970  -10.9199
            20  C8x C    27.4095  -11.6199
            21  C8y C    28.6219  -10.9199
            22  C8x C    28.6219   -9.5200
            23  C8x C    27.4095   -8.8200
            24  O2a O    29.8344  -11.6199
            25  C1b C    31.0468  -10.9199
            26  C1b C    32.2592  -11.6199
            27  C8y C    33.4717  -10.9199
            28  C8y C    33.4717   -9.5200
            29  C1a C    32.2592   -8.8200
            30  N5x N    34.8031  -11.3525
            31  C8y C    35.6259  -10.2200
            32  O2x O    34.8031   -9.0874
            33  C8y C    37.0300  -10.2200
            34  C8x C    37.7300  -11.4324
            35  C8x C    39.1300  -11.4324
            36  C8x C    39.8300  -10.2200
            37  C8x C    39.1300   -9.0075
            38  C8x C    37.7300   -9.0075
BOND        41
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     4   9 1
            10    9  10 1
            11   10  11 2
            12   10  12 1
            13   12  13 1
            14   14  15 1
            15   15  16 1
            16   12  16 1
            17   15  17 2
            18   13  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   18  23 1
            25   21  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 2
            30   28  29 1
            31   27  30 1
            32   30  31 2
            33   31  32 1
            34   28  32 1
            35   31  33 1
            36   33  34 2
            37   34  35 1
            38   35  36 2
            39   36  37 1
            40   37  38 2
            41   33  38 1

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