KEGG   DRUG: RasburicaseHelp
Entry
D05704                      Drug                                   

Name
Rasburicase (USAN/INN);
Rasburicase (genetical recombination) (JAN);
Elitek (TN)
Product
Sequence
C2H3O-SAVKAARYGK DNVRVYKVHK DEKTGVQTVY EMTVCVLLEG EIETSYTKAD
NSVIVATDSI KNTIYITAKQ NPVTPPELFG SILGTHFIEK YNHIHAAHVN IVCHRWTRMD
IDGKPHPHSF IRDSEEKRNV QVDVVEGKGI DIKSSLSGLT VLKSTNSQFW GFLRDEYTTL
KETWDRILST DVDATWQWKN FSGLQEVRSH VPKFDATWAT AREVTLKTFA EDNSASVQAT
MYKMAEQILA RQQLIETVEY SLPNKHYFEI DLSWHKGLQN TGKNAEVFAP QSDPNGLIKC
TVGRSSLKSK L
  Type
Peptide
Source
Aspergillus flavus [TAX:5059]
Remark
Therapeutic category: 
ATC code: 
Activity
Uricolytic
Comment
urate oxidase [KO:K00365] [EC:1.7.3.3]
Rasburicase is contraindicated in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency [DS:H00668] because this can precipitate hemolytic anemia.
Treatment of malignancy-associated or chemotherapy-induced hyperuricemia
Interaction
Genomic biomarker: G6PD [HSA:2539]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AF Detoxifying agents for antineoplastic treatment
     V03AF07 Rasburicase
      D05704  Rasburicase (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D05704  Rasburicase (USAN/INN); Rasburicase (genetical recombination) (JAN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05704
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05704
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D05704
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D05704
BRITE hierarchy
Other DBs
CAS: 
134774-45-1
PubChem: 
DrugBank: 
LinkDB All DBs

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