KEGG   DRUG: D05704Help
Entry
D05704                      Drug                                   

Name
Rasburicase (genetical recombination) (JAN);
Rasburicase (USAN/INN);
Elitek (TN)
Product
Sequence
C2H3O-SAVKAARYGK DNVRVYKVHK DEKTGVQTVY EMTVCVLLEG EIETSYTKAD
NSVIVATDSI KNTIYITAKQ NPVTPPELFG SILGTHFIEK YNHIHAAHVN IVCHRWTRMD
IDGKPHPHSF IRDSEEKRNV QVDVVEGKGI DIKSSLSGLT VLKSTNSQFW GFLRDEYTTL
KETWDRILST DVDATWQWKN FSGLQEVRSH VPKFDATWAT AREVTLKTFA EDNSASVQAT
MYKMAEQILA RQQLIETVEY SLPNKHYFEI DLSWHKGLQN TGKNAEVFAP QSDPNGLIKC
TVGRSSLKSK L
  Type
Peptide
Source
Aspergillus flavus [TAX:5059]
Activity
Treatment of malignancy-associated or chemotherapy-induced hyperuricemia
Remark
Therapeutic category: 
ATC code: 
Comment
urate oxidase [KO:K00365] [EC:1.7.3.3]
Rasburicase is contraindicated in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency [DS:H00668] because this can precipitate hemolytic anemia.
Interaction
Genomic biomarker: G6PD [HSA:2539]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AF Detoxifying agents for antineoplastic treatment
     V03AF07 Rasburicase
      D05704  Rasburicase (genetical recombination) (JAN); Rasburicase (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D05704  Rasburicase (genetical recombination) (JAN); Rasburicase (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
134774-45-1
PubChem: 
DrugBank: 
LinkDB All DBs

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