| Entry |
|
|---|
| Name |
Forodesine (USAN/INN);
Fodosine (TN) |
|---|
| Formula |
C11H14N4O4
|
|---|
| Exact mass |
266.1015
|
|---|
| Mol weight |
266.25
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Remark |
| Product (DG01392): | D04245<JP> |
|
|---|
| Efficacy |
Antineoplastic, Purine nucleoside phosphorylase (PNP) inhibitor |
|---|
| Comment |
Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-Cell lymphoma (CTCL)
|
|---|
| Target |
|
|---|
| Pathway |
| hsa00760 | Nicotinate and nicotinamide metabolism |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Enzymes
Transferases (EC2)
Pentosyltransferases
PNP
D06596 Forodesine (USAN/INN)
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 19
1 C1y C 27.4995 -18.3298
2 C1y C 28.8986 -18.3298
3 C1y C 29.3308 -16.9992
4 N1x N 28.1990 -16.1770
5 C1y C 27.0672 -16.9992
6 O1a O 26.6772 -19.4616
7 O1a O 29.7208 -19.4616
8 C1b C 25.7485 -16.5708
9 C8y C 30.6496 -16.5708
10 O1a O 24.7050 -17.5103
11 C8y C 31.7103 -17.4906
12 C8y C 32.9130 -16.7677
13 N4x N 32.5972 -15.4005
14 C8x C 31.1993 -15.2783
15 N5x N 31.7349 -18.8895
16 C8x C 32.9586 -19.5676
17 N4x N 34.1613 -18.8447
18 C8y C 34.1367 -17.4459
19 O5x O 35.3469 -16.7185
BOND 21
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 1 5 1
6 1 6 1 #Down
7 2 7 1 #Down
8 5 8 1 #Up
9 3 9 1 #Up
10 8 10 1
11 9 11 1
12 11 12 2
13 12 13 1
14 13 14 1
15 9 14 2
16 11 15 1
17 15 16 2
18 16 17 1
19 17 18 1
20 12 18 1
21 18 19 2
|
|---|
