| Entry |
|
|---|
| Name |
Carfilzomib (INN/USAN);
Kyprolis (TN)
|
|---|
| Product |
|
|---|
| Formula |
C40H57N5O7
|
|---|
| Exact mass |
719.4258
|
|---|
| Mol weight |
719.9099
|
|---|
| Structure |
     |
|---|
| Activity |
Treatment of cancer
|
|---|
| Target |
proteasome subunit beta type-5 inhibitor [HSA: 5693] [KO: K02737] |
|---|
| Pathway |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases
proteasome subunit beta type-5 (PSMB5) [HSA:5693] [KO:K02737]
Carfilzomib
D08880 Carfilzomib (INN/USAN)
 |
|---|
| Other DBs |
CAS: 868540-17-4 PubChem: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 52
1 C1b C 11.3830 -17.9082
2 C5a C 12.5990 -17.2061
3 N1b N 13.8151 -17.9082
4 C1c C 15.0311 -17.2061
5 C5a C 16.2471 -17.9082
6 N1b N 17.4632 -17.2061
7 C1c C 18.6793 -17.9082
8 C5a C 19.8953 -17.2061
9 N1b N 21.1114 -17.9082
10 C1c C 22.3274 -17.2061
11 C5a C 23.5435 -17.9082
12 N1b N 24.7595 -17.2061
13 C1c C 25.9755 -17.9082
14 C5a C 27.1917 -17.2061
15 N1y N 10.1670 -17.2061
16 C1z C 28.3193 -17.8990
17 C1x C 10.1670 -15.8022
18 C1x C 8.9510 -15.1001
19 O2x O 7.7348 -15.8020
20 C1x C 7.7348 -17.2061
21 C1x C 8.9510 -17.9082
22 O5a O 27.1409 -15.8023
23 O5a O 23.5435 -19.3123
24 O5a O 19.8953 -15.8020
25 O5a O 16.2471 -19.3123
26 O5a O 12.5990 -15.8022
27 C1b C 22.3274 -15.8019
28 C1b C 15.0311 -15.8019
29 C1b C 25.9755 -19.3124
30 C1b C 18.6793 -19.3124
31 O2x O 29.5378 -17.2392
32 C1x C 29.5353 -18.6011
33 C8y C 23.5495 -15.0964
34 C1b C 16.2492 -15.0987
35 C8y C 16.2492 -13.6945
36 C8x C 17.4483 -13.0020
37 C8x C 17.4481 -11.5979
38 C8x C 16.2320 -10.8960
39 C8x C 15.0330 -11.5883
40 C8x C 15.0331 -12.9925
41 C8x C 24.7516 -15.7905
42 C8x C 25.9677 -15.0886
43 C8x C 25.9679 -13.6845
44 C8x C 24.7658 -12.9902
45 C8x C 23.5497 -13.6922
46 C1c C 19.8953 -20.0145
47 C1a C 21.0984 -19.3197
48 C1a C 19.8953 -21.4185
49 C1c C 27.1916 -20.0145
50 C1a C 28.3988 -19.3174
51 C1a C 27.1917 -21.4186
52 C1a C 28.3193 -16.4948
BOND 55
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 6 7 1
7 7 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 11 12 1
12 12 13 1
13 13 14 1
14 1 15 1
15 14 16 1
16 15 17 1
17 17 18 1
18 18 19 1
19 19 20 1
20 20 21 1
21 15 21 1
22 14 22 2
23 11 23 2
24 8 24 2
25 5 25 2
26 2 26 2
27 10 27 1 #Up
28 4 28 1 #Up
29 13 29 1 #Down
30 7 30 1 #Down
31 16 31 1
32 16 32 1
33 31 32 1
34 27 33 1
35 28 34 1
36 34 35 1
37 35 36 2
38 36 37 1
39 37 38 2
40 38 39 1
41 39 40 2
42 35 40 1
43 33 41 2
44 41 42 1
45 42 43 2
46 43 44 1
47 44 45 2
48 33 45 1
49 30 46 1
50 46 47 1
51 46 48 1
52 29 49 1
53 49 50 1
54 49 51 1
55 16 52 1 #Up
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