KEGG   DRUG: D09620Help
Entry
D09620                      Drug                                   

Name
Fresolimumab (USAN/INN)
Formula
C6392H9926N1698O2026S44
Exact mass
144297.3591
Mol weight
144386.2278
Sequence
(Heavy chain) QVQLVQSGAE VKKPGSSVKV SCKASGYTFS SNVISWVRQA
PGQGLEWMGG VIPIVDIANY AQRFKGRVTI TADESTSTTY MELSSLRSED TAVYYCASTL
GLVLDAMDYW GQGTLVTVSS ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS
WNSGALTSGV HTFPAVLQSS GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES
KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD
GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK
GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS
DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGK
(Disulfide bridge: 22-96; 147-203; 261-321; 367-425, Dimer: 226; 229)
(Light chain) ETVLTQSPGT LSLSPGERAT LSCRASQSLG SSYLAWYQQK
PGQAPRLLIY GASSRAPGIP DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYADSPITFG
QGTRLEIKRT VAAPSVFIFP PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS
QESVTEQDSK DSTYSLSSTL TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: 23-89; 135-195; H134-L215)
  Type
Peptide
Activity
Idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, and cancer
Comment
Monoclonal antibody
Target
TGFB [HSA:7040 7042 7043] [KO:K13375 K13376 K13377]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04350  TGF-beta signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  TGF-beta family
   TGFB
    Fresolimumab
     D09620  Fresolimumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
948564-73-6
PubChem: 
LinkDB All DBs

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