KEGG   DRUG: D10056Help
Entry
D10056                      Drug                                   

Name
Robatumumab (USAN/INN)
Formula
C6418H9960N1732O1992S42
Exact mass
144511.9584
Mol weight
144600.8942
Sequence
(Heavy chain) EVQLVQSGGG LVKPGGSLRL SCAASGFTFS SFAMHWVRQA
PGKGLEWISV IDTRGATYYA DSVKGRFTIS RDNAKNSLYL QMNSLRAEDT AVYYCARLGN
FYYGMDVWGQ GTTVTVSSAS TKGPSVFPLA PSSKSTSGGT AALGCLVKDY FPEPVTVSWN
SGALTSGVHT FPAVLQSSGL YSLSSVVTVP SSSLGTQTYI CNVNHKPSNT KVDKKVEPKS
CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV
DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA
KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD
SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK
(Light chain) EIVLTQSPGT LSVSPGERAT LSCRASQSIG SSLHWYQQKP
GQAPRLLIKY ASQSLSGIPD RFSGSGSGTD FTLTISRLEP EDFAVYYCHQ SSRLPHTFGQ
GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ
ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer; dislfide bridge: H22-H95, H145-H201, H221-L214, H227-H'227, H230-H'230, H262-H322, H368-H426, H'22-H'95, H'145-H'201, H'221-L'214, H'262-H'322, H'368-H'426, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Activity
Oncology
Comment
Monoclonal antibody
Target
insulin-like growth factor 1 receptor [HSA:3480] [KO:K05087]
  Pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin-like growth factor 1 receptor [HSA:3480] [KO:K05087]
     Robatumumab
      D10056  Robatumumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
934235-44-6
PubChem: 
LinkDB All DBs

» Japanese version   » Back

DBGET integrated database retrieval system