KEGG   DRUG: D10058Help
Entry
D10058                      Drug                                   

Name
Solanezumab (genetical recombination) (JAN);
Solanezumab (USAN/INN)
Formula
C6396H9922N1712O1996S42
Exact mass
143993.5792
Mol weight
144082.2207
Sequence
(heavy chain) EVQLVESGGG LVQPGGSLRL SCAASGFTFS RYSMSWVRQA
PGKGLELVAQ INSVGNSTYY PDTVKGRFTI SRDNAKNTLY LQMNSLRAED TAVYYCASGD
YWGQGTLVTV SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS
GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKKV EPKSCDKTHT
CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH
NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE
PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF
LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP G
(light chain) DVVMTQSPLS LPVTLGQPAS ISCRSSQSLI YSDGNAYLHW
FLQKPGQSPR LLIYKVSNRF SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCSQSTHVP
WTFGQGTKVE IKRTVAAPSV FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ
SGNSQESVTE QDSKDSTYSL SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(dimer; disulfide bridge: H22-H96, H139-H195, H215-L219, H221-H'221, H224-H'224, H256-H316, H362-H420, H'22-H'96, H'139-H'195, H'215-L'219, H'256-H'316, H'362-H'420, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Activity
Alzheimer's disease
Comment
Monoclonal antibody
Target
beta-amyloid
Structure map
Agents for Alzheimer-type dementia
Other DBs
CAS: 
955085-14-0
PubChem: 
LinkDB All DBs

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